Tag Archives: neurological symptoms

FDA-approved immune-modulating drug unexpectedly benefits mice with fatal mitochondrial defect

The transplant anti-rejection drug rapamycin showed unexpected benefits in a mouse model of a fatal defect in the energy powerhouses of cells, the mitochondria. Children with the condition, Leigh syndrome, show progressive brain damage, muscle weakness, lack of coordination or muscle control, and weight loss, and usually succumb to respiratory failure.

Leigh syndrome is often diagnosed within the first year of life. Affected children rarely survive beyond 6 or 7 years. At present, the disorder, which can result from several different underlying causes, has no effective treatment. (more…)

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Facing the Migraine

Migraines are a chronic brain condition characterized by attacks of a throbbing headache, of medium or strong intensity, possibly associated with nausea, vomiting, photophobia and intolerance to sounds (phonophobia). In about a third of cases, seizures are accompanied by neurological symptoms, usually visual, known as auras. The disorder occurs in those who are genetically susceptible. The World Health Organization estimates that worldwide there are 324 million people who suffer from in this condition. (more…)

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