Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.
The findings, reported in the Aug. 12 issue of the journal Nature Medicine, show that the genetic switch known as a transcription factor represses the expression of several genes that are necessary for the formation of synaptic connections between brain cells, which in turn could contribute to loss of brain mass in the prefrontal cortex. (more…)
UCLA study also finds that mindfulness technique benefits immune system
Many elderly people spend their last years alone. Spouses pass and children scatter. But being lonely is much more than a silent house and a lack of companionship. Over time, loneliness not only takes a toll on the psyche but can have a serious physical impact as well.
Feeling lonely has been linked to an increased risk of heart disease, Alzheimer’s disease, depression and even premature death. Developing effective treatments to reduce loneliness in older adults is essential, but previous treatment efforts have had limited success. (more…)
COLUMBUS, Ohio – Chronic exposure to dim light at night can lead to depressive symptoms in rodents – but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.
While hamsters exposed to light at night for four weeks showed evidence of depressive symptoms, those symptoms essentially disappeared after about two weeks if they returned to normal lighting conditions.
Even changes in the brain that occurred after hamsters lived with chronic light at night reversed themselves after returning to a more normal light cycle. (more…)
Understanding this phenomenon could improve psychological support systems for sexual minorities and help young people avoid alcohol problems.
COLUMBIA, Mo. — Many young adults explore and define their sexual identity in college, but that process can be stressful and lead to risky behaviors. In a new study, students whose sexual self-definition didn’t fall into exclusively heterosexual or homosexual categories tended to misuse alcohol more frequently than people who had a firmly defined sexual orientation for a particular gender, according to University of Missouri researchers. These findings could be used to improve support programs for sexual minorities.
“Bisexuals and students whose sexual orientation was in flux reported the heaviest drinking and most negative consequences from alcohol use, such as uncontrolled drinking and withdrawal symptoms,” said Amelia Talley, MU assistant professor of psychological sciences in the College of Arts and Science. “Those groups reported drinking to relieve anxiety and depression at higher rates than strictly heterosexual or homosexual individuals. One possible explanation is that people who aren’t either completely heterosexual or homosexual may feel stigmatized by both groups.” (more…)
*UCLA-launched partnership identifies genes that boost or lessen risk of brain atrophy, mental illness, Alzheimer’s disease*
In the world’s largest brain study to date, a team of more than 200 scientists from 100 institutions worldwide collaborated to map the human genes that boost or sabotage the brain’s resistance to a variety of mental illnesses and Alzheimer’s disease.
Published April 15 in the advance online edition of the journal Nature Genetics, the study also uncovers new genes that may explain individual differences in brain size and intelligence. (more…)
Most of us know what it means when it’s said that someone is depressed. But commonly, true clinical depression brings with it a number of other symptoms. These can include anxiety, poor attention and concentration, memory issues, and sleep disturbances.
Traditionally, depression researchers have sought to identify the individual brain areas responsible for causing these symptoms. But the combination of so many symptoms suggested to UCLA researchers that the multiple symptoms of depression may be linked to a malfunction involving brain networks — the connections that link different brain regions. (more…)
COLUMBIA, Mo. – This year, more than 230,000 women will be diagnosed with breast cancer and nearly 40,000 women will not survive their battle with cancer, according to the American Cancer Society. New research from the University of Missouri shows that certain factors, including marital status, having children in the home, income level and age, affect the likelihood of depression in breast cancer survivors. Further, depressed patients are less likely to adhere to medication regimens, potentially complicating the progress of their treatment.(more…)
Children with depressed parents get stressed out more easily than children with healthy parents—if the depressed parents are negative toward their child. That’s the conclusion of a study published in an upcoming issue of Psychological Science, a journal of the Association for Psychological Science.
The study is part of a long-term look at how a child’s early temperament is related to the risk for depression. The children were recruited for the study when they were three years old, an age when depression is rare. Thus, the researchers expect to see depression appear as the children grow. (more…)
