Tag Archives: cancer

200,000 Malaria Deaths Preventable Annually, says U of T Researcher

*Deaths in India vastly underestimated*

Professor Prabhat Jha of medicine and an international team of researchers from India, Canada and the U.K. say their new studty shows the number of premature deaths from malaria in India has been vastly underestimated.

The new study is of a nationally representative sample of all deaths from any cause in India, asking family members to describe the fatal illness. Its results show that malaria accounts for about 200,000 (2 lakh) premature deaths before age 70 in India (including 80,000 children below age 15 and 120,000 adults). Previous estimates of malaria deaths were less than 10 per cent of this new figure. (more…)

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Discovery of a Mechanism that Controls the Expression of a Protein Involved in Numerous Cancers

Marc Therrien. Image credit: University of Montreal

Researchers at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have identified a new mechanism controlling the transmission of an abnormal signal at the origin of several cancers. In an article published in the journal Cell, Marc Therrien’s team explains the recent discovery of a protein complex that controls the RAS/MAPK signalling pathway, responsible for some of the deadliest cancers, including pancreatic, colon and lung cancers, and melanomas. This regulating mechanism could prove to be a promising therapeutic target for the treatment of these diseases.  The study conducted on the drosophila model organism is to be verified in humans in a forthcoming step. (more…)

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U of T researcher discovers key protein involved in DNA repair

*Discovery gives insight into the way cells protect their own genetic material* 

In a groundbreaking study, U of T researchers including Professors Daniel Durocher, AnneClaude Gingras and Frank Sicheri have uncovered a protein called OTUB1 that blocks DNA damage in the cell—a discovery that may lead to the development of strategies to improve some cancer therapies.

(more…)

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