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Radiation Generates Cancer Stem Cells From Less Aggressive Breast Cancer Cells

By Guest PostFebruary 19, 2012Healthbreast cancer, cancer cell, chemotherapy, dna damage, frank pajonk, ibcsc, induced pluripotent stem cells, ips, kim irwin, oncologist, radiation therapy, radiation treatment, regenerative medicine, stem cell, tumor, tumor recurrence

Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.

Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)

High Population Density is Greatest Risk Factor For Water-Linked Diseases

By Guest PostFebruary 17, 2012Healthbo lu, c k shum, central africa, dengue fever, diarrhea, disease transmission, doug alsdorf, e coli, eastern brazil, environmental change, environmental condition, gideon, global analysis, hazards, hot spots, infectious disease, insect bite, jeffrey lejeune, kun yang, latin america, legionella, malaria, model, northern india, ohio state database, population density, risk factor, routes, schistosomiasis, song liang, southeast asia, surface area, trypanosomiasis, water associated, water bodies, western europe

COLUMBUS, Ohio – Water-associated infectious disease outbreaks are more likely to occur in areas where a region’s population density is growing, according to a new global analysis of economic and environmental conditions that influence the risk for these outbreaks.

Ohio State University scientists constructed a massive database containing information about 1,428 water-associated disease outbreaks that were reported between 1991 and 2008 around the world. By combining outbreak records with data on a variety of socio-environmental factors known about the affected regions, the researchers developed a model that can be used to predict risks for water-associated disease outbreaks anywhere in the world. (more…)

When Nerve Meets Muscle, Biglycan Seals The Deal

By Guest PostFebruary 16, 2012Healthcell culture, motor neuron disease, neuromuscular junction, protein biglycan, spinal muscular atrophy, synaptic stability

In the absence of the protein biglycan, synapses at neuromuscular junctions in mice began to break up about five weeks after birth, according to a new study led by Brown University researchers. Reintroducing byglycan helped fix the loss of synaptic stability in cell culture. The research may be relevant to efforts to treat motor neuron diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig’s Disease) and spinal muscular atrophy. (more…)

Scientists Sound Alarm over Threat of Untreatable Gonorrhea in United States

By Guest PostFebruary 14, 2012Healthdrug resistant gonorrhea, gonococcal infections, united states, untreatable gonorrhea

Researchers are continuing to sound the alarm on the growing threat of multi-drug resistant gonorrhea in the United States, according to a perspective in the Feb. 9 issue of the New England Journal of Medicine. (more…)

New Device Removes Stroke-Causing Blood Clots Better Than Standard Treatment

By Guest PostFebruary 13, 2012Health, Scienceblood clot, catheter tube, covidien, elad levy, Europe, experimental device, flow restoration device, jeffrey l saver, merci retriever, raul nogueira, reza jahan, solitaire, stroke patient, swift, thrombectomy, tissue plasminogen activator, tudor g jovin, ucla stroke center, united states

An experimental device for removing blood clots in stroke patients dramatically outperformed the standard mechanical treatment, according to research presented by UCLA Stroke Center director Dr. Jeffrey L. Saver at the American Stroke Association’s 2012 international conference in New Orleans on Feb. 3.

The SOLITAIRE Flow Restoration Device is among an entirely new generation of devices designed to remove blood clots from blocked brain arteries in patients experiencing stroke. It has a self-expanding, stent-like design and, once inserted into a clot using a thin catheter tube, it compresses and traps the clot. The clot is then removed by withdrawing the device, thus reopening the blocked blood vessel. (more…)

Treatment For TB Can Be Guided By Patients’ Genetics

By Guest PostFebruary 11, 2012Healthdivergent inflammatory states, drug treatment, fighting inflammation, goldilocks effect, heterozygous advantage, tuberculosis

A gene that influences the inflammatory response to infection may also predict the effectiveness of drug treatment for a deadly form of tuberculosis. (more…)

Why Bad Immunity Genes Survive

By Guest PostFebruary 10, 2012Health, Scienceankylosing spondylitis, antagonistic co evolution, antibiotics, arms race, autoimmune diseases, bacteria, cells, cornelius whitney hyzer, gene, genetics, george gilchrist, germs, immune system, infection, infectious diseases, james ruff, jason kubinak, major histocompatibility complex, mhc, mhc variants, mhcs, mice, national science foundation, parasite, pathogens, patricia slev, people, protein, university of utah, variant, vertebrate animals, virus, wayne potts

*Study implicates “arms race” between genes and germs*

Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.

“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)

Gene Mutation Discovery Sparks Hope For Effective Endometriosis Screening

By Guest PostFebruary 9, 2012Healthendometrial growth, endometrial risk, endometriosis screening, gene mutation

Researchers at Yale School of Medicine have, for the first time, described the genetic basis of endometriosis, a condition affecting millions of women that is marked by chronic pelvic pain and infertility. The researchers’ discovery of a new gene mutation provides hope for new screening methods. (more…)

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