Scientists have discovered a rare genetic mutation that increases the risk of Alzheimer’s disease.
The international team, led by researchers at the UCL Institute of Neurology, studied data from more than 25,000 people and found a link between a rare variant of the TREM2 gene – which is known to play a role in the immune system – and a higher risk of Alzheimer’s. (more…)
Molecular ‘tweezers’ break up toxic aggregations of proteins in mouse model
Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson’s disease from binding together and killing the brain’s neurons.
Building on those findings, they have now turned their attention to Alzheimer’s disease, which is thought to be caused by a similar toxic aggregation or clumping, but with different proteins, especially amyloid-beta and tau. (more…)
UCLA infectious diseases doctor played key role in finance strategy for therapy
A new international program, conceived in part by a UCLA physician, has rapidly transformed access to lifesaving anti-malarial drugs by providing cheap, subsidized artemisinin-based combination therapies in seven African countries that account for a quarter of the world’s malaria cases.
The first independent evaluation of the Affordable Medicines Facility–malaria (AMFm) program was recently published in the journal The Lancet. The program is based at the Global Fund in Geneva, an international financing institution dedicated to disbursing funds to prevent and treat infectious diseases. The evaluation shows that the program improved access to key artemisinin combination therapies, or ACTs, which offer broader protection and less antibiotic resistance than anti-malaria medications currently available in those African nations. (more…)
ANN ARBOR — While most Americans look forward to eating turkey on Thanksgiving, Pacific Islanders in the U.S. and on the islands are most likely to eat a part of the bird few other Americans are familiar with: its tail. (more…)
A new study published online in the journal Human Reproduction finds that the greater the inconsistency in the length of sperm, particularly in the tail (flagellum), the lower the concentration of sperm that can swim well. The finding offers fertility clinicians a potential new marker for fertility trouble that might trace back to how a patient’s sperm are being made.
PROVIDENCE, R.I. [Brown University] — Perhaps variety is the very spice of life, but as a matter of producing human life, it could be the bane of existence. That’s the indication of a new study in the journal Human Reproduction that found men with wider variation in sperm length, particularly in the flagellum, had lower concentrations of sperm that could swim well. Those with more consistently made sperm seemed to have more capable ones. (more…)
EAST LANSING, Mich. — A study led by a Michigan State University researcher offers the strongest evidence yet that reflexology – a type of specialized foot massage practiced since the age of pharaohs – can help cancer patients manage their symptoms and perform daily tasks. (more…)
Initial results in mice could lead to new way to fight neurodegenerative diseases
There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.
The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)
In a new study, addiction researchers found that attentive parenting can overcome a genetic predisposition to alcohol use disorder among teens. Although further research is needed, says lead author Robert Miranda Jr., parents can have an impact if they “closely monitor their child’s behavior and peer group.”
In 2010 a team led by Robert Miranda Jr., associate professor (research) of psychiatry and human behavior in the Warren Alpert Medical School of Brown University, found that teens with a single difference in their genes were more predisposed to alcohol use disorder. In a new study in Alcoholism: Clinical and Experimental Research he found that the risk was largely overcome in teens whose parents are attentive to their behavior and peer group. Miranda, a researcher at Brown’s Center for Alcohol and Addiction Studies, answered questions from science writer David Orenstein about the new study.
What did we know about genetic risk associated with A118G and teenage alcohol use going into this study?
In 2010, we reported in Alcoholism: Clinical and Experimental Research the first evidence that the A118G SNP of the OPRM1 gene is associated with a greater number of alcohol-related problems as well as the development of an alcohol use disorder (AUD) among adolescents. Specifically, adolescents who met criteria for an AUD diagnosis had a higher prevalence of the G allele (51.9 percent) than non-AUD youth(16.3 percent), and the G allele accounted for 9 percent of the variance in alcohol-related problems experienced by youth in the past three months, with a moderate effect size. Although these findings are consistent with some adult studies in terms of the nature and magnitude of this association, other adult studies did not find this relationship. (more…)
