*Rizia Bardhan, a postdoc at the Molecular Foundry, selected to Forbes’ ’30 under 30′ list*
On a typical day, Rizia Bardhan walks through the doors of Lawrence Berkeley National Laboratory’s Molecular Foundry and immerses herself in the tricky business of tweaking optical spectroscopy equipment to study phase transitions in metal hydrides.
It’s fair to say that what she does is difficult to grasp. Why she does it is easy: “I want to help solve big problems. That’s why I’m here,” she says. (more…)
AUSTIN, TX — Researchers from The University of Texas at Austin’s Department of Chemical Engineering are the first to show that mechanical property changes in cells may be responsible for cancer progression — a discovery that could pave the way for new approaches to predict, treat and prevent cancer.
Postdoctoral student Parag Katira and his adviser, Roger T. Bonnecaze, department chair in the Cockrell School of Engineering and T. Brockett Hudson Professor, worked with Muhammad Zaman of Boston University to devise a 3-D cancer model that shows the softening of cells and changes in cell binding cause cancerous behavior in cells. These mechanical property changes cause cells to divide uncontrollably — making them less likely to die and resulting in malignant tumor growth. The findings present a unique physics-based perspective on understanding cancer progression and were published recently in the American Physical Society’s journal Physical Review Letters. (more…)
Some images of stark Martian landscapes provide visual appeal beyond their science value, including a recent scene of wind-sculpted features from the High Resolution Imaging Science Experiment (HiRISE) camera on NASA’s Mars Reconnaissance Orbiter.
The scene shows dunes and sand ripples of various shapes and sizes inside an impact crater in the Noachis Terra region of southern Mars. Patterns of dune erosion and deposition provide insight into the sedimentary history of the area. (more…)
ANCHORAGE — On its way to deliver emergency fuel to Nome, Alaska, the Russian tanker Renda will move through an area used by wintering spectacled eiders, a federally threatened sea duck. But, to protect the ducks and their wintering habitat, resource managers from the U.S. Fish and Wildlife Service and navigators from the U.S. Coast Guard are using satellite telemetry information from the U.S. Geological Survey to plot a route for the tanker that minimizes impacts to this species and its habitat.
“Nearly 20 years ago, USGS biologists used the latest satellite tracking technology available at the time to uncover the mysterious wintering behavior of the spectacled eider, now a threatened species,” said USGS Director Marcia McNutt. “Little did these scientists know at the time that their information would be critical in allowing a Russian tanker decades later to thread the needle to Nome in order to deliver life-saving fuel oil without taking a toll on these elusive sea ducks.” (more…)
*Berkeley Lab Researchers Find Evidence Suggesting Risk May Not Be Proportional to Dose at Low Dose Levels*
Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of human breast cells, have found evidence to suggest that for low dose levels of ionizing radiation, cancer risks may not be directly proportional to dose. This contradicts the standard model for predicting biological damage from ionizing radiation – the linear-no-threshold hypothesis or LNT – which holds that risk is directly proportional to dose at all levels of irradiation.
“Our data show that at lower doses of ionizing radiation, DNA repair mechanisms work much better than at higher doses,” says Mina Bissell, a world-renowned breast cancer researcher with Berkeley Lab’s Life Sciences Division. “This non-linear DNA damage response casts doubt on the general assumption that any amount of ionizing radiation is harmful and additive.” (more…)
UCLA life scientists and colleagues have produced the most comprehensive mathematical model ever devised to track the health of populations exposed to environmental change.
The research, federally funded by the National Science Foundation, is published Dec. 2 in the journal Science.
The team’s groundbreaking integral projection model, or IPM, unites various sub-disciplines of population biology, including population ecology, quantitative genetics, population genetics, and life-span and offspring information, allowing researchers to link many different data sources simultaneously. Scientists can now change just a single variable, like temperature, and see how that affects many factors for a population.(more…)
*Increasing yield in poorer countries could decrease adverse environmental effects*
Global food demand could double by 2050, according to a new projection reported this week in the journal Proceedings of the National Academy of Sciences (PNAS).
The analysis also shows that the world faces major environmental challenges unless agricultural practices change.
Scientists David Tilman and Jason Hill of the University of Minnesota (UMN) and colleagues found that producing the amount of food needed could significantly increase levels of carbon dioxide and nitrogen in the environment, and may cause the extinction of numerous species. (more…)
Critical genetic secrets of a bacterium that holds potential for removing toxic and radioactive waste from the environment have been revealed in a study by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). The researchers have provided the first ever map of the genes that determine how these bacteria interact with their surrounding environment.
“Knowing how bacteria respond to environmental changes is crucial to our understanding of how their physiology tracks with consequences that are both good, such as bioremediation, and bad, such as biofouling,” says Aindrila Mukhopadhyay, a chemist with Berkeley Lab’s Physical Biosciences Division, who led this research. “We have reported the first systematic mapping of the genes in a sulfate-reducing bacterium – Desulfovibrio vulgaris – that regulate the mechanisms by which the bacteria perceive and respond to environmental signals.” (more…)
