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Distinct Brain Cells Recognize Novel Sights

By Guest PostApril 16, 2012Sciencebrain area, brain cell, brown university, cell type, david orenstein, david sheinberg, excitatory neuron, inferior temporal cortex, itc, luke woloszyn, novel sight, plasticity, repair circuit, skull, traumatic brain injury

The brain’s ability to learn to recognize objects plays out in the inferior temporal cortex. A new study offers a possible explanation of how two classes of neurons play distinct roles to help that happen.

PROVIDENCE, R.I. [Brown University] — No matter what novel objects we come to behold, our brains effortlessly take us from an initial “What’s that?” to “Oh, that old thing” after a few casual encounters. In research that helps shed light on the malleability of this recognition process, Brown University neuroscientists have teased apart the potentially different roles that two distinct cell types may play.

In a study published online in advance in the journal Neuron, the researchers document that this kind of learning is based in the inferior temporal cortex (ITC), a brain area buried deep in the skull. Scientists already knew the area was important for visual recognition of familiar items, but they hadn’t figured out the steps required to move from novelty to familiarity, a process they refer to as “plasticity.” (more…)

Bats Save Energy By Drawing in Wings on Upstroke

By Guest PostApril 13, 2012Nature, Scienceaerodynamics, attila bergou, bat wings, bats, brown university, calculation, calculus rich model, daniel riskin, david orenstein, flying machine, inertial energy, muscular wings, physicisist, sharon swartz, wing mass

Bat wings are like hands: meaty, bony and full of joints. A new Brown University study finds that bats take advantage of their flexibility by folding in their wings on the upstroke to save inertial energy. The research suggests that engineers looking at flapping flight should account for wing mass and consider a folding design.

PROVIDENCE, R.I. [Brown University] — Whether people are building a flying machine or nature is evolving one, there is pressure to optimize efficiency. A new analysis by biologists, physicists, and engineers at Brown University reveals the subtle but important degree to which that pressure has literally shaped the flapping wings of bats.

The team’s observations and calculations show that by flexing their wings inward to their bodies on the upstroke, bats use only 65 percent of the inertial energy they would expend if they kept their wings fully outstretched. Unlike insects, bats have heavy, muscular wings with hand-like bendable joints. The study suggests that they use their flexibility to compensate for that mass. (more…)

Constantine Gatsonis: Better Triage for Chest Pains

By Guest PostMarch 27, 2012Scienceacrin, acute coronary syndrome, biostatistician, brad snyder, brown, cancer, cardiac disease, ccta, constantine gatsonis, ct angiography, david orenstein, erin greco, heart attack, philadelphia, radiology

In a study in The New England Journal of Medicine, authors including biostatisticians from Brown report that coronary computed tomographic angiography (CCTA) is a safe way to screen patients coming to the ER with chest pains who are not at high risk for acute coronary syndrome. Patients who got CCTA and tested negative were more likely to be discharged home and spend less time at the hospital.

Coronary computed tomographic angiography (CCTA), a technology for diagnostic imaging of the heart, is a safe way to assess whether patients whose risk of heart attack is not high need to be hospitalized when they arrive at the emergency room complaining of chest pains. Brown biostatisticians led by Constantine Gatsonis are part of a team of researchers who report that finding in The New England Journal of Medicine and at the American College of Cardiology Conference March 26. (more…)

Will a Genetic Mutation Cause Trouble? Ask Spliceman

By Guest PostMarch 5, 2012Scienceaaa, ata, brown university, chimpanzees, david orenstein, dna sequences, gene, genetic mutation, human genome mutation database, humans, kian huat lim, messenger rna, Rhesus monkeys, shamil sunyaev, spliceman, web based program, william fairbrother

New, free Web-based software described in the journal Bioinformatics analyzes DNA sequences to determine if mutations are likely to cause errors in splicing of messenger RNA. When gene splicing goes awry, a wide variety of diseases can result.

PROVIDENCE, R.I. [Brown University] — In a brief paper in the journal Bioinformatics, Brown University researchers describe a new, freely available Web-based program called Spliceman for predicting whether genetic mutations are likely to disrupt the splicing of messenger RNA, potentially leading to disease.

“Spliceman takes a set of DNA sequences with point mutations and computes how likely these single nucleotide variants alter splicing phenotypes,” write co-authors Kian Huat Lim, a graduate student, and William Fairbrother, assistant professor of biology, in an “application note” published in advance online Feb. 10. It will appear in print in April. (more…)

Andrew Artenstein: Essential Enzymes Key to Disease, Maybe Treatments

By Guest PostJanuary 2, 2012Healthalzheimer, andrew artenstein, anthrax, athlerosclerosis, bacteria and viruses, biodefense, body, cancer, chemical reactions, david orenstein, disease, ebola, enzymes, essential proteins, Europe, flu, iaips, infectious diseases, inter alpha inhibitor proteins, measles, microscopic level, molecules, natural human proteins, outbreak of h1n1, pathways, pcs, proprotein convertases, proteins, sars, steven opal, therapies, viruses

*Proprotein convertases are enzymes that activate many essential proteins, but they are also implicated in many processes that cause disease. In a research review in the New England Journal of Medicine, Andrew Artenstein and Steven Opal argue that proprotein convertases are potentially rich targets for developing therapies.*

Most people have never heard of proprotein convertases, but the enzymes activate many proteins that are essential for life. Unfortunately, their fundamental role puts them in the middle of many processes that cause disease – not just cancer or athlerosclerosis, but both of those and Alzheimer’s and anthrax and the flu and an amazing variety of other maladies.

In a research review article appearing Dec. 29 in the New England Journal of Medicine, Andrew Artenstein, physician-in-chief in the Department of Medicine at Memorial Hospital, and Steven Opal, chief of infectious diseases at Memorial Hospital, argue that proprotein convertases (PCs) are potentially rich targets for developing therapies. Artenstein, who with Opal is on the faculty of the Warren Alpert School of Medicine, explained PCs to David Orenstein. (more…)

New Study to Test Unusual Hypothesis on Beta Brainwaves

By Guest PostDecember 4, 2011Sciencebasal ganglia, beta, beta brainwaves, beta oscillations, brown university, christopher moore, cortex, david orenstein, hypothesis, key brain circuit, model, moore and jones, neurons, neuroscientists, optogenetics, parkinsonian symptoms, parkinsons disease, physical brain, predictions, sensory information, somatosensory system, stephanie jones, thalamocortical circuit, thalamus, touch, touch perception circuit

Beta oscillations are tightly linked to Parkinson’s disease and the ability to process sensory information, such as touch. Two neuroscientists have brought their collaboration to Brown University and won funding from the National Science Foundation to see if they can finally provide a definitive, if unorthodox, explanation for beta brainwaves.

Before she could seek to convince the world that her computer model of a key brain circuit explains a fundamental, 80-year-old mystery of neuroscience with potential relevance to Parkinson’s disease, Stephanie Jones sought to convince Christopher Moore. The new Brown neuroscience professors are now close collaborators, but when they first started talking about the beta oscillations of the cortex, Moore thought Jones was plain wrong, if not a bit nuts. (more…)

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