EAST LANSING, Mich. — The rate of workplace deaths in Michigan remained steady in 2011, as 141 workers died on the job compared with 145 in 2010, according to an annual report from Michigan State University.
The construction industry had the most deaths at 24, while the agriculture industry had the second most at 22, according to the Michigan Fatality Assessment and Control Evaluation program, or MIFACE. (more…)
With technological advancements opening the door to less invasive medical procedures, robotic-assisted surgery is becoming increasingly popular, despite being more expensive than traditional surgery. Robotic-assisted surgical removal of the bladder due to cancer is a new approach to the traditional “open” — or more invasive — operation called a radical cystectomy.
Bladder cancer is the fourth most commonly diagnosed cancer in men, and the American Cancer Society estimates that 73,500 people will be diagnosed with bladder cancer in 2012. A third of those will require a radical cystectomy. (more…)
Researchers have devised a nanoscale sensor to electronically read the sequence of a single DNA molecule, a technique that is fast and inexpensive and could make DNA sequencing widely available.
The technique could lead to affordable personalized medicine, potentially revealing predispositions for afflictions such as cancer, diabetes or addiction. (more…)
In a study in The New England Journal of Medicine, authors including biostatisticians from Brown report that coronary computed tomographic angiography (CCTA) is a safe way to screen patients coming to the ER with chest pains who are not at high risk for acute coronary syndrome. Patients who got CCTA and tested negative were more likely to be discharged home and spend less time at the hospital.
Coronary computed tomographic angiography (CCTA), a technology for diagnostic imaging of the heart, is a safe way to assess whether patients whose risk of heart attack is not high need to be hospitalized when they arrive at the emergency room complaining of chest pains. Brown biostatisticians led by Constantine Gatsonis are part of a team of researchers who report that finding in The New England Journal of Medicine and at the American College of Cardiology Conference March 26. (more…)
*Berkeley Lab Researchers Identify Structure of Key Control Element Behind Protein Misfolding That Can Lead to Disease*
The gold standard for nanotechnology is nature’s own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids – are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.
A team of researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab), using the exceptionally bright and powerful x-ray beams of the Advanced Light Source, have determined the crystal structure of a critical control element within chaperonin, the protein complex responsible for the correct folding of other proteins. The incorrect or “misfolding” of proteins has been linked to many diseases, including Alzheimer’s, Parkinson’s and some forms of cancer. (more…)
ANN ARBOR, Mich.— Using a liquid laser, University of Michigan researchers have developed a better way to detect the slight genetic mutations that might predispose a person to a particular type of cancer or other diseases.
Their results are published in the current edition of the German journal Angewandte Chemie. (more…)
AUSTIN, TX — A new form of proteins discovered by researchers at The University of Texas at Austin could drastically improve treatments for cancer and other diseases, as well as overcome some of the largest challenges in therapeutics: delivering drugs to patients safely, easily and more effectively.
The protein formulation strategy, discovered by chemical engineering faculty members and students in the Cockrell School of Engineering, is unprecedented and offers a new and universal approach to drug delivery — one that could revolutionize treatment of cancer, arthritis and infectious disease. (more…)
*Proprotein convertases are enzymes that activate many essential proteins, but they are also implicated in many processes that cause disease. In a research review in the New England Journal of Medicine, Andrew Artenstein and Steven Opal argue that proprotein convertases are potentially rich targets for developing therapies.*
Most people have never heard of proprotein convertases, but the enzymes activate many proteins that are essential for life. Unfortunately, their fundamental role puts them in the middle of many processes that cause disease – not just cancer or athlerosclerosis, but both of those and Alzheimer’s and anthrax and the flu and an amazing variety of other maladies.
In a research review article appearing Dec. 29 in the New England Journal of Medicine, Andrew Artenstein, physician-in-chief in the Department of Medicine at Memorial Hospital, and Steven Opal, chief of infectious diseases at Memorial Hospital, argue that proprotein convertases (PCs) are potentially rich targets for developing therapies. Artenstein, who with Opal is on the faculty of the Warren Alpert School of Medicine, explained PCs to David Orenstein. (more…)
