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Costly Breast Cancer Screenings Don’t Add up to Better Outcomes

By Guest PostJanuary 22, 2013Healthanees chagpar, breast cancer, breast cancer incidence, brigid killelea, cary gross, copper team, cost of screening, geographic regions, heather gold, jama network publication, jessica long, joseph ross, mammography, maysa abu khalaf, medicine, rong wang, screenings, treatment, united states, variation, xiaomei ma, yale cancer center, yale school

Even though Medicare spends over $1 billion per year on breast cancer screenings such as a mammography, there is no evidence that higher spending benefits older women, researchers at Yale School of Medicine found in a study published Online First by JAMA Internal Medicine, a JAMA Network publication.

Led by Dr. Cary Gross, associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, the study sought to provide a comprehensive understanding of breast cancer expenditures that incorporate the cost of screening and associated work-up, as well as treatment. They assessed overall national costs, as well as variation in costs across geographic regions. (more…)

Study Explains Skin’s Response to UVA Light

By Guest PostJanuary 22, 2013Healthdna damage, melanin production, phototransduction pathway, skin cells, ultraviolet light, uva exposure, uva light

Researchers have strengthened their understanding of how skin cells called melanocytes sense ultraviolet light and act to protect themselves with melanin. In a new study, they report experiments showing that an ion channel well-known elsewhere in the body for its chemical sensitivity, plays a central role in this process. (more…)

New Insights into the ‘Borderline Personality’ Brain

By Guest PostJanuary 21, 2013Healthanger, anthony c ruocco, borderline personality disorder, bpd, brain function, brain region, chaotic relationship, cycle, data, diagnosis and treatment, disorders, emotion dysregulation, emotional reaction, frontal part, function of brains, hallmark symptom, hyperactive, insula, major depression, mental illness, negative emotions, neural circuits, people with bpd, sadness, scarborough, suicide, university of toronto

TORONTO, ON — New work by University of Toronto Scarborough researchers gives the best description yet of the neural circuits that underlie a severe mental illness called Borderline Personality Disorder (BPD), and could lead to better treatments and diagnosis.

The work shows that brain regions that process negative emotions (for example, anger and sadness) are overactive in people with BPD, while brain regions that would normally help damp down negative emotions are underactive. (more…)

Genes and obesity: Fast food isn’t only culprit in expanding waistlines — DNA is also to blame

By Guest PostJanuary 19, 2013Healthadipose, bmi, body fat response, body mass index, brian parks, cancer, control, degree of obesity, diverse mouse population, DNA, elin org, elizabeth nam, emrah kostem, environmental conditions, environmental factors, epidemic, fast food diet, fat, fat tissue, frode norheim, genetic factor, genetics, global gene expression, heart disease, high calorie diets, inbred strains, intestinal bacteria, intestinal flora, jake lusis, level, metabolic response, mice, modeling, obesity traits, sedentary lifestyles, strains, sugar, type 2 diabetes, ucla, weight gain

Researchers at UCLA say it’s not just what you eat that makes those pants tighter — it’s also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modeling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity. (more…)

Body Weight and Gender Influence Judgment in the Courtroom

By Guest PostJanuary 15, 2013Healthalleged defendant, bias, body weight, depth of stigmatization, discrimination, gender, journal of obesity, lean female, lean male, natasha schvey, obese female, obese male, obese people, overweight, perceptions of guilt, responsibility, weight related stigma, weight stigma, yale rudd center

In a study that offers insight into the depth of stigmatization of overweight and obese people, researchers at the Yale Rudd Center for Food Policy & Obesity found that weight stigma extends to the courtroom. Published online in the International Journal of Obesity, the study shows that a defendant’s body weight and gender impact jurors’ perceptions of guilt and responsibility.

Researchers conducted an online study with 471 adult participants. They were presented with a mock court case, including images of alleged defendants. Participants viewed one of four defendant images: a lean male, a lean female, an obese male, and an obese female. After viewing the image, participants were then asked to rate how guilty they thought the defendant was. (more…)

Helping Patients Navigate New Cancer Drugs

By Guest PostJanuary 14, 2013Healthautomated calling system, barbara given, cancer clinic, cancer treatment, chemotherapy, chemotherapy pills, chronic conditions, cutting edge treatment, cycle, diarrhea, dose, Environment, fatigue, ineffective, intravenous drugs, journal cancer nursing, life threatening disease, manage symptoms, michigan state university, monitor, multiple medications, oral chemotherapy drugs, oral pills, pain, patient, pill, sandra spoelstra, severe nausea, skin reactions, vomiting

As cancer treatment in pill form transforms how care is delivered, a new Michigan State University study underscores the challenges patients face in administering their own chemotherapy outside the supervised environment of a cancer clinic.

Chemotherapy pills can target specific cancers better than some traditional intravenous drugs, said Sandra Spoelstra, the MSU assistant professor of nursing who led the study. But they also can be difficult for patients to take. (more…)

Virus Caught in the Act of Infecting a Cell

By Guest PostJanuary 12, 2013Health, Scienceaustin, bacterium, bo hu, cryo electron tomography, ct scan, e coli, experimental evidence, feelers, fibers, genetic, genetic material, head, human hair, ian molineux, image, infect, infect a cell, infected cell membrane, infection, infection process, jun liu, protein, protein path, robot like process, structure, t7, texas, thickness, university, ut health, viral dna, virus, visualize, william margolin

About the video: watch an animation showing the changes in the structure of a T7 virus as it infects an E. coli bacterium.

AUSTIN, Texas — The detailed changes in the structure of a virus as it infects an E. coli bacterium have been observed for the first time, report researchers from The University of Texas at Austin and The University of Texas Health Science Center at Houston (UT Health) Medical School this week in Science Express. (more…)

Multiple Sclerosis Study Reveals How Killer T Cells Learn to Recognize Nerve Fiber Insulators

By Guest PostJanuary 12, 2013Healtharsenal, autoimmune disorders, autoimmune encephalitis, autoimmune reactivity, axons, blood vessels, body, brain, branched tentacles, cancer, cd4+ t cell, cd8 t cells, central nervous system, chronic multiple sclerosis, corticosteroids, cytoxic t cells, degeneration of axons, electrical impulse conductors, electrical wire, fight disease, generalized immunosuppressants, humans, infection, inflamed lesions, inflammatory response, inflammatory situation, insulation, joan goverman, killer t cells, laboratory models, lesions, luca castelli, methotrexate, mouse model, multiple sclerosis, myelin protein, myelin sheath, nerve cell projections, nerve fibers, no cells, oligodendrocytes, pathogens, peptides, proteins, qingyong ji, spines, support cells, symptoms, tip dendritic cells, tissue damage, transmit signals, university of washington, white blood cells

Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body’s arsenal to fight disease.

Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively. (more…)

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