Michigan State University researchers have uncovered a genetic deficiency in males that can trigger the development of one of the most common types of liver cancer and forms of diabetes.
The research, published in the online issue of Cancer Cell, found that when the NCOA5 gene, present in both men and women, was altered in male mice to a deficient level, a spontaneous reaction occurred producing cells that can lead to hepatocellular carcinoma, a type of liver cancer found to be two-to-four times more prevalent in men than women. (more…)
A growing body of evidence suggests that the brain plays a key role in glucose regulation and the development of type 2 diabetes, researchers write in the Nov. 7 ssue of the journal Nature. If the hypothesis is correct, it may open the door to entirely new ways to prevent and treat this disease, which is projected to affect one in three adults in the United States by 2050.
In the paper, lead author Dr. Michael W. Schwartz, UW professor of medicine and director of the Diabetes and Obesity Center of Excellence, and his colleagues from the universities of Cincinnati, Michigan, and Munich, note that the brain was originally thought to play an important role in maintaining normal glucose metabolism With the discovery of insulin in the 1920s, the focus of research and diabetes care shifted to almost exclusively to insulin. Today, almost all treatments for diabetes seek to either increase insulin levels or increase the body’s sensitivity to insulin. (more…)
Research shows a correlation between eating breakfast and a reduced risk of type 2 diabetes
As Americans continue to fight the obesity epidemic and try to stem the incidence of type 2 diabetes, dietary guidelines are becoming increasingly important.
Among the possible keys to better health? Eating breakfast, for starters. (more…)
A large, newly published study that includes more than 13,500 postmenopausal women has yielded the most definitive associations yet between certain lifestyle and demographic factors and levels of a promising early biomarker of type 2 diabetes risk.
PROVIDENCE, R.I. [Brown University] — Over the last decade researchers have amassed increasing evidence that relatively low levels of a protein called sex hormone binding globulin (SHBG) can indicate an elevated risk of type 2 diabetes and metabolic syndrome years in advance. (more…)
Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the “missing heritability” problem.
A new study by Princeton University researchers, however, suggests that missing heritability may not be missing after all — at least not in yeast cells, which the researchers used as a model for studying the problem. Published in the journal Nature, the results suggest that heritability in humans may be hidden due only to the limitations of modern research tools, but could be discovered if scientists know where (and how) to look. (more…)
Researchers at UCLA say it’s not just what you eat that makes those pants tighter — it’s also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.
The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modeling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity. (more…)
The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible.
COLUMBIA, Mo. — Following a three-year study using more than 2,800 mice, a University of Missouri researcher was not able to replicate a series of previous studies by another research group investigating the controversial chemical BPA. The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible. The MU study, published in the Proceedings of the National Academy of Sciences, also investigated an estrogenic compound found in plants, genistein, in the same three-year study.
“Our findings don’t say anything about the positive or negative effects of BPA or genistein,” said Cheryl Rosenfeld, associate professor of biomedical sciences in MU’s Bond Life Science Center. “Rather, our series of experiments did not detect the same findings as reported by another group on the potential developmental effects of BPA and genistein when exposure of young occurs in the womb.” (more…)
COLUMBUS, Ohio – Eating mindfully, or consuming food in response to physical cues of hunger and fullness, is just as effective as adhering to nutrition-based guidelines in reducing weight and blood sugar levels in adults with Type 2 diabetes, a new study suggests.(more…)
