Animal research suggests ibuprofen can reduce lung inflammation in elderly
COLUMBUS, Ohio – New research shows that the lungs become more inflammatory with age and that ibuprofen can lower that inflammation.
In fact, immune cells from old mouse lungs fought tuberculosis bacteria as effectively as cells from young mice after lung inflammation was reduced by ibuprofen. The ibuprofen had no effect on the immune response to TB in young mice. (more…)
Bacteria in a drop of water spontaneously form a bi-directional vortex, with bacteria near the center of the drop swimming in the opposite direction of bacteria swimming near the edge. New computer simulations, confirmed by a novel experiment, explain how that vortex comes to be.
PROVIDENCE, R.I. [Brown University] — When a bunch of B. subtilis bacteria are confined within a droplet of water, a very strange thing happens. The chaotic motion of all those individual swimmers spontaneously organizes into a swirling vortex, with bacteria on the outer edge of the droplet moving in one direction while those on the inside move the opposite direction. (more…)
University of Utah researchers find that multiple silent mutations greatly impact protein translation
So-called silent DNA mutations earned their title because, according to the fundamental rules of biology, they should be inconsequential. Reported on June 5 in PLOS Genetics online, University of Utah researchers experimentally proved there are frequent exceptions to the rule. The work was conducted in the bacteria, Salmonella enterica, used to study basic biological mechanisms that are often conserved in humans. (more…)
Where and how you live strongly influences both the type and number of microbes you carry on your hands, according to a new international study led by scientists at Yale and Stanford.
The research identified and analyzed bacteria on the hands of women in Tanzania and graduate students in the United States, finding that bacterial populations were more similar among the subjects within a country than between subjects of different countries. (more…)
Stanford, CA — Photosynthesis provides fixed carbon and energy for nearly all life on Earth, yet many aspects of this fascinating process remain mysterious. For example, little is known about how it is regulated in response to changes in light intensity. More fundamentally, we do not know the full list of the parts of the molecular machines that perform photosynthesis in any organism.
A type of single-cell green algae called Chlamydomonas reinhardtii is a leading subject for photosynthesis research. Despite its importance in the research world, few tools are available for characterizing the functions of its genes. (more…)
Berkeley Researchers Show Expanded Role for Guide RNA in Cas9 Interactions with DNA
The potential is there for bacteria and other microbes to be genetically engineered to perform a cornucopia of valuable goods and services, from the production of safer, more effective medicines and clean, green, sustainable fuels, to the clean-up and restoration of our air, water and land. Cells from eukaryotic organisms can also be modified for research or to fight disease. To achieve these and other worthy goals, the ability to precisely edit the instructions contained within a target’s genome is a must. A powerful new tool for genome editing and gene regulation has emerged in the form of a family of enzymes known as Cas9, which plays a critical role in the bacterial immune system. Cas9 should become an even more valuable tool with the creation of the first detailed picture of its three-dimensional shape by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. (more…)
How’s this for innovative: A Berkeley Lab-led team hopes to engineer a new enzyme that efficiently converts methane to liquid transportation fuel.
“There’s a lot of methane available, and we want to develop a new way to harness it as an energy source for vehicles,” says Christer Jansson, a biochemist in Berkeley Lab’s Earth Sciences Division who heads the effort. (more…)
To safely use bacteria in agriculture to help fertilize crops, it is vital to understand the difference between harmful and healthy strains. The bacterial genus Burkholderia, for example, includes dangerous disease-causing pathogens — one species has even been listed as a potential bioterrorist agent — but also many species that are safe and important for plant development.
Can the microbial good and evil be told apart? Yes, UCLA life scientists and an international team of researchers report Jan. 8 in the online journal PLOS ONE. (more…)
