Tag Archives: brown university

Mice Have System to Handle Smell of Fear

By Guest PostJuly 24, 2012Sciencebarnea laboratory, brain, brown university, carnivore, david valenzuela, dheeraj roy, gene expression, gilad barnea, glomeruli, instinctive behavior, lion, lulu tsai, mark a johnson, mice, neuron, olfactory bulb, predator, receptor gene, smell of fear, stavros lomvardas, stephen liberles, subsystem, system, taar, taar proteins, tiger, urine

Mice appear to have a specialized system for detecting and at least initially processing instinctually important smells such as those that denote predators. The finding raises a question about whether their response to those smells is hardwired.

PROVIDENCE, R.I. [Brown University] — A new study finds that mice have a distinct neural subsystem that links the nose to the brain and is associated with instinctually important smells such as those emitted by predators. That insight, published online this week in Proceedings of the National Academy of Sciences, prompts the question whether mice and other mammals have specially hardwired neural circuitry to trigger instinctive behavior in response to certain smells.

In the series of experiments and observations described in the paper, the authors found that nerve cells in the nose that express members of the gene family of trace amine-associated receptors (TAAR) have several key biological differences from the much more common and diverse neurons that express members of the olfactory receptor gene family. Those other nerve cells detect a much broader range of smells, said corresponding author Gilad Barnea, the Robert and Nancy Carney Assistant Professor of Neuroscience at Brown University. (more…)

El Zotz Masks Yield Insights into Maya beliefs

By Guest PostJuly 19, 2012Culture, Science3d image, ancient america, archaeological site, boris beltran, brown university, cast, cultural heritage, diablo pyramid, dupee family, edwin roman, el zotz, guatemala, hieroglyphic text, kinich ajaw, maya belief, maya civilization, Mexico City, night sun, pre colombian mesoamerica, sarah newman, stephen houston, stuccos, sun god, temple, tikal

A team of archaeologists led by Stephen Houston has made a new discovery at the Maya archaeological site in El Zotz, Guatemala, uncovering a pyramid believed to celebrate the Maya sun god. The structure’s outer walls depict the god in an unprecedented set of images done in painted stucco. In 2010, the team uncovered a royal tomb filled with artifacts and human remains at the same site. Researchers believe the pyramid was built to link the deceased lord to the eternal sun.

PROVIDENCE, R.I. [Brown University] — A team of archaeologists led by Brown University’s Stephen Houston has uncovered a pyramid, part of the Maya archaeological site at El Zotz, Guatemala. The ornately decorated structure is topped by a temple covered in a series of masks depicting different phases of the sun, as well as deeply modeled and vibrantly painted stucco throughout.

The team began uncovering the temple, called the Temple of the Night Sun, in 2009. Dating to about 350 to 400 A.D., the temple sits just behind the previously discovered royal tomb, atop the Diablo Pyramid. The structure was likely built after the tomb to venerate the leader buried there. (more…)

Training Improves Recognition of Rapid-Fire Objects

By Guest PostJuly 12, 2012Scienceattentional blink, attentional function, brain activity, brown university, fmri machine, gibberish character, hoon choi, Kazuhisa Shibata, li hung chang, perception, rapid fire objects, sequence, Takeo Watanabe, visual perception

“Attentional blink” is the term psychologists use to describe our inability to recognize a second important object if we see it less than half a second after a first one. It always seemed impossible to overcome, but in a new paper in the Proceedings of the National Academy of Sciences, Brown University psychologists report they’ve found a way.

PROVIDENCE, R.I. [Brown University] — So far it has seemed an irreparable limitation of human perception that we strain to perceive things in the very rapid succession of, say, less than half a second. Psychologists call this deficit “attentional blink.” We’ll notice that first car spinning out in our path, but maybe not register the one immediately beyond it. It turns out, we can learn to do better after all. In a new study researchers now based at Brown University overcame the blink with just a little bit of training that was never been tried before. (more…)

Diagnostic Technique Uses Immune Cell DNA

By Guest PostJuly 10, 2012Scienceafrican american, bladder cancer, blood samples, brock christensen, brown university, carmen marsit, cd4, cell carcinoma, cell membrane, chemical alteration, devin koestler, DNA, granulocyte leukocytes, immune cell, karl kelsey, leukocytes, methylation, ovarian cancer, t lymphocytes

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring.

PROVIDENCE, R.I. [Brown University] — When a person is sick, there is a tell-tale sign in their blood: a different mix of the various types of immune cells called leukocytes. A group of scientists at several institutions including Brown University has discovered a way to determine that mix from the DNA in archival or fresh blood samples, potentially providing a practical new technology not only for medical research but also for clinical diagnosis and treatment monitoring of ailments including some cancers. (more…)

Lariats: How RNA Splicing Decisions are Made

By Guest PostJune 24, 2012Sciencealec desimone, allison taggart, branchpoint, brown university, byproduct, code for protein, disease, gene transcription, genetic snippet, isoform, janice shih, lariat formation, lariats, loop, madeleine filloux, rna splicing, william fairbrother

Lariats are discarded byproducts of RNA splicing, the process by which genetic instructions for making proteins are assembled. A new study has found hundreds more lariats than ever before, yielding new information about how splicing occurs and how it can lead to disease.

PROVIDENCE, R.I. [Brown University] — Tiny, transient loops of genetic material, detected and studied by the hundreds for the first time at Brown University, are providing new insights into how the body transcribes DNA and splices (or missplices) those transcripts into the instructions needed for making proteins.

The lasso-shaped genetic snippets — they are called lariats — that the Brown team reports studying in the June 17 edition of Nature Structural & Molecular Biology are byproducts of gene transcription. Until now scientists had found fewer than 100 lariats, mostly by poring over very small selections of introns, which are sections of genetic code that do not directly code for proteins, but contain important signals that direct the way protein-coding regions are assembled. In the new study, Brown biologists report that they found more than 800 lariats in a publicly available set of billions of RNA reads derived from human tissues. (more…)

Combating Global Problems at BIARI

By Guest PostJune 22, 2012Environment, General, Scienceaids, ambedkar university delhi, anita elizabeth cherian, armed conflict, barbara willaarts, biari, botin foundation, brazil, brown university, cape town, China, chinese cities, civil society, climate change, courtney coelho, development, end project evaluation, environmental awareness, ethiopia, global problem, grass stage theatre, hiv, hiv awareness, India, junia quiroga de cuhan, kathamandu university, ke zhang, latin america, laureate universities, maria cecelia trannin, nepal, new delhi, nigeria, peking university, population, qing hui hou, rebecca hodes, rio de janeiro, rukmini sen, sagar sharma, shimla, South Africa, university, yunnan province, zheng xie

Some 140 participants and 30 visiting faculty from more than 45 countries arrived at Brown to take part in the Brown International Advanced Research Institutes (BIARI). The two-week program began June 11, 2012.

PROVIDENCE, R.I. [Brown University] — Some 140 participants and 30 visiting faculty from more than 45 countries arrived at Brown to take part in the Brown International Advanced Research Institutes (BIARI). Participants, who were chosen from a pool of more than 850 applicants, come from several countries, including Brazil, China, Nigeria, India, and Ethiopia.

The two-week program began Monday, June 11, 2012. Now in its fourth year, BIARI is centered around four two-week intensive institutes, convened concurrently by Brown faculty, in which participants and leading scholars in their fields share their research and develop new collaborative projects through sustained, high-level dialogue spanning disciplines and continents. This year’s institutes touched on global health and HIV/AIDS; theater and civil society; population and development; and climate change. (more…)

A SMART(er) Way to Track Influenza

By Guest PostJune 12, 2012Scienceaartik sarma, amplification, andrew artenstein, anubhav tripathi, biological debris, brown assay, brown university, carmichael ong, DNA, first aid kit, flu detection test, genetic sequence, H1N1, hiv, influenza rna, influenza rna sequence, iPhone, magnetics, memorial hospital, microfluidics, nasba, nucleic acid sequence, pigs, polymerase chain reaction, prototype, rhode island, rna partners, rna probe, rna strand, smart, smart detector, stephanie mccalla, steven opal, swine flu, tb, tracking of influenza, tuberculosis, united states, virus in mexico

Brown University researchers have created a reliable and fast flu-detection test that can be carried in a first-aid kit. The novel prototype device isolates influenza RNA using a combination of magnetics and microfluidics, then amplifies and detects probes bound to the RNA. The technology could lead to real-time tracking of influenza. Results are published in the Journal of Molecular Diagnostics.

PROVIDENCE, R.I. [Brown University] — In April 2009, the world took notice as reports surfaced of a virus in Mexico that had mutated from pigs and was being passed from human to human. The H1N1 “swine flu,” as the virus was named, circulated worldwide, killing more than 18,000 people, according to the World Health Organization. The Centers for Disease Control and Prevention in the United States said it was the first global pandemic in more than four decades. (more…)

More Seniors Being Held for Observation

By Guest PostJune 10, 2012General, Healthaffordable care act, brad wright, brown university, david orenstein, elderly patients, emergency departments, gerontologists, health affairs, hospitals, medicare, vincent mor, zhanlian feng

A new study finds that more elderly patients in the emergency departments of hospitals are being held for observation rather than admitted as inpatients. Pressure from Medicare to reduce unnecessary hospitalization may be driving the trend. But being classified as an outpatient, rather than being admitted, can increase out-of-pocket costs for patients. The study is reported in the June edition of Health Affairs.

PROVIDENCE, R.I. [Brown University] — Nobody wins when patients stay in the hospital unnecessarily, so the federal government in recent years has pushed hospitals to be careful about admitting Medicare recipients as inpatients. The apparent result is that more patients are being “held for observation” instead, according to a new study by Brown University gerontologists. While the shift in how hospitals care for elderly patients in the emergency department may reduce costs to Medicare, it can also increase out-of-pocket expenditures for patients. (more…)