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A SMART(er) Way to Track Influenza

By Guest PostJune 12, 2012Scienceaartik sarma, amplification, andrew artenstein, anubhav tripathi, biological debris, brown assay, brown university, carmichael ong, DNA, first aid kit, flu detection test, genetic sequence, H1N1, hiv, influenza rna, influenza rna sequence, iPhone, magnetics, memorial hospital, microfluidics, nasba, nucleic acid sequence, pigs, polymerase chain reaction, prototype, rhode island, rna partners, rna probe, rna strand, smart, smart detector, stephanie mccalla, steven opal, swine flu, tb, tracking of influenza, tuberculosis, united states, virus in mexico

Brown University researchers have created a reliable and fast flu-detection test that can be carried in a first-aid kit. The novel prototype device isolates influenza RNA using a combination of magnetics and microfluidics, then amplifies and detects probes bound to the RNA. The technology could lead to real-time tracking of influenza. Results are published in the Journal of Molecular Diagnostics.

PROVIDENCE, R.I. [Brown University] — In April 2009, the world took notice as reports surfaced of a virus in Mexico that had mutated from pigs and was being passed from human to human. The H1N1 “swine flu,” as the virus was named, circulated worldwide, killing more than 18,000 people, according to the World Health Organization. The Centers for Disease Control and Prevention in the United States said it was the first global pandemic in more than four decades. (more…)

Treatment For TB Can Be Guided By Patients’ Genetics

By Guest PostFebruary 11, 2012Scienceanti-inflammatory, charles serhan, corticosteroids, david tobin, dexamethasone therapy, duke university, francisco roca, gene, gene variant, genetic sequence, goldilocks effect, guy thwaites, harvard university, heterozygous advantage, human genetics, hyperinflammation, infection, inflammation, inflammatory response, lalita ramakrishnan, leukotriene b4, lipoxins, lta4h, mary claire king, mutation, oxford university, patient, pro inflammatory, seattle, substance, tb, tb like infection, tb meningitis, tuberculosis, tuberculosis treatment, university of washington, Vietnam, zebrafish

A gene that influences the inflammatory response to infection may also predict the effectiveness of drug treatment for a deadly form of tuberculosis.

An international collaboration between researchers at the University of Washington in Seattle, Duke University, Harvard University, the Oxford University Clinical Research Unit in Vietnam and Kings College London reported these findings Feb. 3 in the journal Cell. (more…)

Researchers Find ‘Goldilocks’ of DNA Self-Assembly

By Guest PostOctober 28, 2010Scienceabhishek singh, assembly technology, DNA, dna assisted self assembly, dna self assembling, dna self assembly, dna strands, genetic coding, genetic sequence, goldilocks, length, materials, north carolina state university, stacy snyder, university of melbourne, yara yingling

This image is a simulation snapshot of the molecular dynamics of DNA strands. Image credit: North Carolina State University

Researchers from North Carolina State University have found a way to optimize the development of DNA self-assembling materials, which hold promise for technologies ranging from drug delivery to molecular sensors. The key to the advance is the discovery of the “Goldilocks” length for DNA strands used in self-assembly – not too long, not too short, but just right.

DNA strands contain genetic coding that will form bonds with another strand that contains a unique sequence of complementary genes. By coating a material with a specific DNA layer, that material will then seek out and bond with its complementary counterpart. This concept, known as DNA-assisted self-assembly, creates significant opportunities in the biomedical and materials science fields, because it may allow the creation of self-assembling materials with a variety of applications.

But, while DNA self-assembly technology is not a new concept, it has historically faced some significant stumbling blocks. One of these obstacles has been that DNA segments that are too short often failed to self-assemble, while segments that are too long often led to the creation of deformed materials. This hurdle can lead to basic manufacturing problems, as well as significant changes in the properties of the material itself. (more…)

Tag Archives: genetic sequence

A SMART(er) Way to Track Influenza

Treatment For TB Can Be Guided By Patients’ Genetics

Researchers Find ‘Goldilocks’ of DNA Self-Assembly