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Mutation Breaks HIV’s Resistance to Drugs, Says MU Researcher

By Guest PostSeptember 22, 2012Health172k, 172k mutation, aids, atsuko hachiya, cellular machinery, drug, hiv, hiv strain, hiv-infected, human, immunodeficiency, inhibitors, missouri, mutation, nnrtis, non nucleoside, nrtis, nucleoside, patient, polymorphism, resistant, reverse, stefan sarafianos, transcriptase, university, virus

Doctors can improve treatment programs using this knowledge

COLUMBIA, Mo. – The human immunodeficiency virus (HIV) can contain dozens of different mutations, called polymorphisms. In a recent study an international team of researchers, including University of Missouri scientists, found that one of those mutations, called 172K, made certain forms of the virus more susceptible to treatment. Soon, doctors will be able to use this knowledge to improve the drug regimen they prescribe to HIV-infected individuals.

“The 172K polymorphism makes certain forms of HIV less resistant to drugs,” said Stefan Sarafianos, corresponding author of the study and a researcher at MU’s Bond Life Sciences Center. “172K doesn’t affect the virus’ normal activities. In some varieties of HIV that have developed resistance to drugs, when the 172K mutation is present, resistance to two classes of anti-HIV drugs is suppressed. We estimate up to 3 percent of HIV strains carry the 172K polymorphism.” (more…)

UCLA Engineers Shed New Light on 3-D Motion of Human Sperm Cells

By Guest PostSeptember 20, 2012Healthhelical movements, helical trajectories, human sperm, human sperm cells, motile human sperms, motion

Using new lensless imaging platform, team observes rare helical movements

A team of researchers from the UCLA Henry Samueli School of Engineering and Applied Science has, for the first time, directly recorded the three-dimensional helical swimming patterns of human sperm cells. (more…)

Researchers Come a Step Closer to Finding HIV Vaccine

By Guest PostSeptember 18, 2012Healthhiv strains, hiv vaccine, hiv vaccine trial, thai trial

Scientists used genetic sequencing to discover that the vaccine used in the RV144 HIV vaccine trial, involving 16,000 men and women in Thailand, did offer some protection against certain HIV viruses. The results were published Sept. 10 in the online edition of Nature. (more…)

Protein Linked to Therapy Resistance in Breast Cancer

By Guest PostSeptember 17, 2012Healthbreast cancer, breast cancer patients, future therapies, invasion of tumors, resistant to treatment, therapy resistance

Berkeley Lab Researchers Identify Possible New Oncogene and Future Therapy Target

A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) with breast cancer resistance to a well-regarded and widely used cancer therapy. (more…)

Reading the Classics: It’s More than Just for Fun

By Guest PostSeptember 16, 2012Health, Scienceblood flow, brain, classic novel, cognitive complexity, critical way, english, Environment, executive function, jane austen, michigan, mri machine, natalie phillips, prejudice, pride, reading, scanner, state university, total cacophony

EAST LANSING, Mich. — Reading a classic novel such as “Pride and Prejudice” can be entertaining, but, according to new research by a Michigan State University professor, it also can provide many other benefits beyond that.

Natalie Phillips, an MSU assistant professor of English, and her team placed study participants in an MRI machine and monitored their brain flow while reading the works of Jane Austen. (more…)

UMD Study Shows Exercise May Protect Against Future Emotional Stress

By Guest PostSeptember 15, 2012Healthacute exercise, aging, alzheimer's disease, anxiety, anxiety level, brain function, carson smith, emotion research, emotional exposure, fmri, functional, iaps database, imaging, kinesiology researcher, magnetic, maryland, mental health, moderate exercise, physical activity, resonance, stress, symptom, university

COLLEGE PARK, Md. – Moderate exercise may help people cope with anxiety and stress for an extended period of time post-workout, according to a study by kinesiology researchers in the University of Maryland School of Public Health published in the journal Medicine and Science in Sports and Exercise.

“While it is well-known that exercise improves mood, among other benefits, not as much is known about the potency of exercise’s impact on emotional state and whether these positive effects endure when we’re faced with everyday stressors once we leave the gym,” explains J. Carson Smith, assistant professor in the Department of Kinesiology. “We found that exercise helps to buffer the effects of emotional exposure. If you exercise, you’ll not only reduce your anxiety, but you’ll be better able to maintain that reduced anxiety when confronted with emotional events.” (more…)

Hospitals that Make Longer Attempts at Resuscitation Have Higher Survival Rates

By Guest PostSeptember 15, 2012Healthamerican, brahmajee nallamotu, cardiac arrest, code blue drill, couple, cpr, cpr duration, cpr effort, defibrillator, electrical charge, heart, heart association, heartbeat, hospital, mannequin, resuscitation, rhythm, survival rate, the lancet, united states, university, Washington, zachary goldberger

Hospitals that continue CPR longer have better survival rates from cardiac arrests, according to a study published online Sept. 5 in The Lancet. The findings challenge the assumption that, if a pulse is not restored soon, continuing resuscitation efforts is futile.

The results also showed that patients who recovered after an extended CPR effort were no more likely to suffer brain damage than are patients revived after a shorter effort. (more…)

Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

By Guest PostSeptember 14, 2012Healthada deficient, adenosine deaminase, bone marrow, bubble boy, chemotherapy, chronic diarrhea, denise carbonaro sarracino, disease, donald kohn, ear infections, enzyme, gene therapy, immune system, immunology, microbiology, molecular genetics, oral candidiasis, recurrent pneumonia, researcher, scid, stem cell, sterile environment, treatment, ucla, virus

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

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