Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man’s best friend, the treatment could help restore vision in people, too.
Published in the journal Molecular Therapy, the study builds on earlier work by Michigan State University veterinary ophthalmologist András Komáromy and colleagues. In 2010, they restored day vision in dogs suffering from achromatopsia, an inherited form of total color blindness, by replacing the mutant gene associated with the condition. (more…)
COLUMBUS, Ohio – Researchers have identified an elusive anti-cancer property of vitamin E that has long been presumed to exist, but difficult to find.
Many animal studies have suggested that vitamin E could prevent cancer, but human clinical trials following up on those findings have not shown the same benefits. (more…)
Scientist works toward molecular therapies for cardiovascular diseases
Born in Leningrad (now St. Petersburg), Russia, to Jewish parents before the fall of the Soviet Union, Michael Simons, M.D., says a medical career was “sort of a default.” Anti-Semitism barred Jews from many scientific pursuits, so his parents, both doctors, encouraged his interest in medicine as the basis for a strong natural science education.
Simons’ family immigrated to Boston in 1978. Simons had begun a 6-year medical program immediately after high school in Russia, so he was admitted to Boston University School of Medicine as a third-year student, but he chose instead to start anew, as an undergraduate. “I thought, if I continue in a medical program, I’ll forever have an inadequate undergraduate education,” he says, speaking with a mild accent and an understated intensity. (more…)
Peer support groups show promise for combating the debilitating stigma that surrounds epilepsy in much of the developing world, according to a new study led by a Michigan State University medical student.
The researchers report in the journal Epilepsy and Behavior that young people with the disease felt significantly less stigmatized after meeting regularly to discuss their illness. (more…)
Many pregnant women with sexually transmitted infections aren’t getting the treatment they need when they visit emergency rooms, according to a new Michigan State University study that highlights a wholly preventable risk to unborn children and raises questions about current medical guidelines.
About half of the 735 women with gonorrhea or chlamydia who visited the ERs at three hospitals in Grand Rapids, Mich. from 2008 through 2010 did not get treatment there, despite the availability of effective and relatively inexpensive antibiotics. Of the 179 who were pregnant, only 20 percent received treatment in the ER. (more…)
Even though Medicare spends over $1 billion per year on breast cancer screenings such as a mammography, there is no evidence that higher spending benefits older women, researchers at Yale School of Medicine found in a study published Online First by JAMA Internal Medicine, a JAMA Network publication.
Led by Dr. Cary Gross, associate professor of internal medicine at Yale School of Medicine and director of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, the study sought to provide a comprehensive understanding of breast cancer expenditures that incorporate the cost of screening and associated work-up, as well as treatment. They assessed overall national costs, as well as variation in costs across geographic regions. (more…)
A new study published in the Archives of Internal Medicine finds that while blood transfusions for heart attack patients with anemia are commonly performed in emergency rooms, the practice can increase the risk of death when the transfusions are too extensive. The authors, led by Saurav Chatterjee, a cardiology fellow at Brown University, compared evidence from 10 prior studies of more than 203,000 patients.
PROVIDENCE, R.I. [Brown University] — When heart attack patients present in the emergency department with some degree of anemia, or anemic patients have a heart attack, physicians have a tendency, but not much guidance, about whether to provide a blood transfusion. The idea is that a transfusion could help more oxygen get to the heart. Recent national guidelines suggested that there simply isn’t good evidence to encourage or discourage the common practice, but a new meta-analysis of 10 studies involving more than 203,000 such patients comes down on the side of it increasing the risk of death. (more…)
Antidepressants are the most widely used treatment for people with moderate to severe depression.
However, up to two thirds of people with depression don’t respond fully to this type of treatment. New findings have shown cognitive behavioural therapy (CBT), provided in addition to usual care, can reduce symptoms of depression and help improve patients’ quality of life.
This is the first large-scale trial to test the effectiveness of CBT – a type of talking psychotherapy- given in addition to usual care that includes antidepressants. The National Institute for Health Research Health Technology Assessment (NIHR HTA)-funded CoBalT study aimed to determine the best ‘next step’ treatment for people whose depression had not responded to medication alone. (more…)
