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University of Toronto Study Demonstrates Impact of Adversity on Early Life Development

By Guest PostOctober 28, 2012Sciencebehavioural geneticist, biology, british columbia, childhood adversity, chris reaume, cifar, dna sequence, drosophila melanogaster, ebbd, Environment, enzyme, evidence, evolutionary biology, food, for, foraging gene, fruit fly, gene, gene robinson, human development, illinois, interaction, james burns, kindergartener, larvae, marla sokolowski, molecular genetics, Nature, neuroscience, pkg, pnas, pre programmed, protein, reproductive fitness, rna, rovers, sitters, tom boyce, toronto, transgenic manipulation, university

Study part of growing body of knowledge surrounding gene-environment interplay

TORONTO, ON – It is time to put the nature versus nurture debate to rest and embrace growing evidence that it is the interaction between biology and environment in early life that influences human development, according to a series of studies recently published in a special edition of the Proceedings of the National Academy of Sciences (PNAS).

“Biologists used to think that our differences are pre-programmed in our genes, while psychologists argued that babies are born with a blank slate and their experience writes on it to shape them into the adults they become. Instead, the important question to be asking is, ‘How is our experience in early life getting embedded in our biology?’” says University of Toronto behavioural geneticist Marla Sokolowski. She is co-editor of the PNAS special edition titled “Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergarteners” along with professors Tom Boyce (University of British Columbia) and Gene Robinson (University of Illinois). (more…)

Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

By Guest PostSeptember 14, 2012Healthada deficient, adenosine deaminase, bone marrow, bubble boy, chemotherapy, chronic diarrhea, denise carbonaro sarracino, disease, donald kohn, ear infections, enzyme, gene therapy, immune system, immunology, microbiology, molecular genetics, oral candidiasis, recurrent pneumonia, researcher, scid, stem cell, sterile environment, treatment, ucla, virus

UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.

In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)

UCLA Biologists Reveal Potential ‘Fatal Flaw’ In Iconic Sexual Selection Study

By Guest PostJune 27, 2012Scienceangus john bateman, charles darwin, common fruit fly, curly wings, descent of man, dna analysis, double mutant offspring, drosophila melanogaster, eastern bluebirds, english geneticist, evolutionary advantage, fatal flaw, female, female behavior, fruit flies, kim derose, male, mate, molecular genetics, mutation, paradigms, patricia adair gowaty, promiscuous, sexual selection, wyatt anderson, yong kyu kim

A classic study from more than 60 years ago suggesting that males are more promiscuous and females more choosy in selecting mates may, in fact, be wrong, say life scientists who are the first to repeat the historic experiment using the same methods as the original.

In 1948, English geneticist Angus John Bateman published a study showing that male fruit flies gain an evolutionary advantage from having multiple mates, while their female counterparts do not. Bateman’s conclusions have informed and influenced an entire sub-field of evolutionary biology for decades.

“Bateman’s 1948 study is the most-cited experimental paper in sexual selection today because of its conclusions about how the number of mates influences fitness in males and females,” said Patricia Adair Gowaty, a distinguished professor of ecology and evolutionary biology at UCLA. “Yet despite its important status, the experiment has never been repeated with the methods that Bateman himself originally used, until now. (more…)

Circadian Rhythms Spark Plants’ Ability to Survive Freezing Weather

By Guest PostApril 14, 2011Scienceabiotic stresses, agbioresearch, bioenergy crops, circadian clock, circadian cues, circadian rhythms, eva farré, freezing weather, malia dong, michael thomashow, microbes, molecular genetics, monarch butterflies, national academy of sciences, renewal biofuels, spark plants

EAST LANSING, Mich. — Just as monarch butterflies depend on circadian cues to begin their annual migration, so do plants to survive freezing temperatures.

All living things – humans, animals, plants, microbes – are influenced by circadian rhythms, which are physical, mental and behavioral changes that follow a 24-hour cycle. In the current issue of the Proceedings of the National Academy of Sciences, Michael Thomashow, University Distinguished Professor of molecular genetics, along with MSU colleagues Malia Dong and Eva Farré, has identified that the circadian clock provides key input required for plants to attain maximum freezing tolerance. (more…)

Tag Archives: molecular genetics

University of Toronto Study Demonstrates Impact of Adversity on Early Life Development

Immune Systems of ‘Bubble Babies’ Restored by Gene Therapy, UCLA Researchers Find

UCLA Biologists Reveal Potential ‘Fatal Flaw’ In Iconic Sexual Selection Study

Circadian Rhythms Spark Plants’ Ability to Survive Freezing Weather