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New Look Inside Cell Nucleus Could Improve Cancer Diagnostics

By Guest PostDecember 31, 2013Sciencebrain cells, cancer diagnostics, cell nucleus, cytoplasm, david galbraith, DNA, enzyme, genetic information, genetic photocopies, genome, genome sequence, messenger rna, organ functions, plant cell, roger lasken, single cell, tumor, types of cancer

Researchers have sequenced the entire messenger RNA – the “genetic photocopies” – contained in the nucleus of a single cell, a long-anticipated step toward better cancer diagnostics and other medical applications.

Researchers have successfully isolated and sequenced the entire messenger RNA – the “genetic photocopies” – contained in the nucleus of a single brain cell. This research, published in the journal Proceedings of the National Academy of Sciences, will help researchers better understand how organs function in health and disease and provide another stepping stone toward personalized medicine. (more…)

Deep Biosphere Harbors Active, Growing Communities of Microorganisms

By Guest PostJuly 9, 2013Environmentamino acids, archaea, bacteria, bill orsi, biochemical mechanisms, carbon, cell, cell populations, data analysis, deep biosphere, ecologist, ecosystem, fungi, glenn christman, global biogeochemical cycles, messenger rna, metatranscriptome, microorganisms, model, molecule atp, mrna, nitrogen cycling, ocean drilling program, sulfate reduction, ud, university of delaware, virginia edgcomb, whoi

The deep biosphere—the realm of sediments far below the seafloor—harbors a vast ecosystem of bacteria, archaea, and fungi that are actively metabolizing, proliferating, and moving, according a new study by scientists at Woods Hole Oceanographic Institution (WHOI) and the University of Delaware (UD).

“This is the first molecular evidence for active cell division in the deep biosphere,” says WHOI postdoctoral investigator Bill Orsi, who was the lead author on the study. Previous studies and models had suggested cells were alive, but whether the cells were actually dividing or not had remained elusive. (more…)

Life underground

By Guest PostJune 14, 2013Environmentactive bacteria, beneath, bioinformatician, carbon, deep biosphere, ecosystem, Environment, fungi, genetic material, heavy pressure, jennifer biddle, life underground, messenger rna, metatranscriptome, microbes, microscopic organisms, million year old, mrna, nucleus containing cells, nutrient sources, ocean, ocean drilling program, oxygen, seafloor, sediment, teresa messmore, university of delaware, virginia edgcomb, volcano, whoi, william orsi

Active microbes discovered far beneath seafloor in ancient ocean sediment

Microbes are living more than 500 feet beneath the seafloor in 5 million-year-old sediment, according to new findings by researchers at the University of Delaware and Woods Hole Oceanographic Institution (WHOI).

Genetic material in mud from the bottom of the ocean — called the deep biosphere —revealed an ecosystem of active bacteria, fungi and other microscopic organisms at depths deeper than a skyscraper is high. The findings were published in Nature on June 12. (more…)

Misregulated genes may have big autism role

By Guest PostApril 1, 2013Healthautism, autism cerebral cortex, bank, biochemical exchanges, brain tissue, brains of children, brown university, christianson syndrome, daniel geschwind, endosomes of cells, epilepsy, eric morrow, genetic pathway, human behavior, irinia voineagu, karoly mirnics, key molecular player, krassimira garbett, los angeles, messenger rna, misregulated genes, mutations, nhe6, nhe9, proteins, raw data, statistical analysis, university of california, vanderbilt university

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.

PROVIDENCE, R.I. [Brown University] — A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research. (more…)

Beacons Light up Stem Cell Transformation

By Guest PostSeptember 12, 2012Sciencealpl, bglap, biotechnology, bone cell, bone specific, brown university, chathuraka jayasuriya, differentiation, DNA, eric darling, fluorescence, gene, gene col1a1, gene expression, glowing, green spot, hetal desai, indu voruganti, medicine treatment, messenger rna, mg 63, milestone, molecular beacon, mrna, qian chen, regenerative, stem cell, tissue

In a new study, Brown University researchers demonstrate a new tool for visually tracking in real-time the transformation of a living population of stem cells into cells of a specific tissue. The “molecular beacons,” which could advance tissue engineering research, light up when certain genes are expressed and don’t interfere with the development or operation of the stem cells.

PROVIDENCE, R.I. [Brown University] — A novel set of custom-designed “molecular beacons” allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly. That’s a key goal in improving regenerative medicine treatments. (more…)

To Cap or Not to Cap: Scientists Find New RNA Phenomenon That Challenges Dogma

By Guest PostSeptember 2, 2012Sciencebaskar bakthavachalu, brian kennedy, cancer, cell, cell life, chandrama mukherjee, cytoplasm, daniel schoenberg, deepak patil, embryonic development, gene, hibernation, messenger rna, mitotic cell cycle, molecule, mrna, neurological activity, ohio state university, protein, rna

COLUMBUS, Ohio – Some RNA molecules spend time in a restful state akin to hibernation rather than automatically carrying out their established job of delivering protein-building instructions in cells, new research suggests.

And instead of being a fluke or a mistake, the research suggests that this restful period appears to be a programmed step for RNA produced by certain types of genes, including some that control cell division and decide where proteins will work in a cell to sustain the cell’s life.

This could mean that protein production in cells is not as clear-cut as biology textbooks suggest, scientists say. (more…)

Will a Genetic Mutation Cause Trouble? Ask Spliceman

By Guest PostMarch 5, 2012Scienceaaa, ata, brown university, chimpanzees, david orenstein, dna sequences, gene, genetic mutation, human genome mutation database, humans, kian huat lim, messenger rna, Rhesus monkeys, shamil sunyaev, spliceman, web based program, william fairbrother

New, free Web-based software described in the journal Bioinformatics analyzes DNA sequences to determine if mutations are likely to cause errors in splicing of messenger RNA. When gene splicing goes awry, a wide variety of diseases can result.

PROVIDENCE, R.I. [Brown University] — In a brief paper in the journal Bioinformatics, Brown University researchers describe a new, freely available Web-based program called Spliceman for predicting whether genetic mutations are likely to disrupt the splicing of messenger RNA, potentially leading to disease.

“Spliceman takes a set of DNA sequences with point mutations and computes how likely these single nucleotide variants alter splicing phenotypes,” write co-authors Kian Huat Lim, a graduate student, and William Fairbrother, assistant professor of biology, in an “application note” published in advance online Feb. 10. It will appear in print in April. (more…)

First Person: How We Discovered Fluoride Riboswitches

By Guest PostJanuary 1, 2012Sciencefluoride riboswitches, messenger rna, oral healthcare, pure fluoride, riboswitch function, rna molecules, ronald breaker

Scientific discoveries come through many different means. Breakthroughs can result from purposefully-executed research projects that are perhaps punctuated with unexpected flashes of insight. In rare cases, discoveries occur through a chain of highly improbable, very lucky, occurrences. (more…)

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