Tag Archives: mechanism

UMass Amherst Biochemists Trap a Chaperone Machine in Action, Opening Pathway to Possible New Cancer Treatment

By Guest PostJanuary 2, 2013Scienceadp, amino acid chains, anastasia zhuravleva, atp, bacteria, cancer cell, chemical environments, cycle, dnak, drug target, e coli bacteria, Environment, eugenia clerico, folding of proteins, heat shock protein, holding pattern, hsp, hsp70, humans, key step, lila gierasch, massachusetts amherst, mechanism, molecular chaperones, molecular machine, nanofactories, neurodegenerative diseases, nmr methods, nuclear magnetic resonance, origami like, ribosomes, stress, uncontrolled growth, university

AMHERST, Mass. – Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists at the University of Massachusetts Amherst led by Lila Gierasch have deciphered key steps in the mechanism of the Hsp70 molecular machine by “trapping” this chaperone in action, providing a dynamic snapshot of its mechanism.

She and colleagues describe this work in the current issue of Cell. Gierasch’s research on Hsp70 chaperones is supported by a long-running grant to her lab from NIH’s National Institute for General Medical Sciences. (more…)

Protein Strongest Just Before Death

By Guest PostDecember 13, 2012Health, Sciencecell death, cell growth, david arnosti, degradation, destruction, drosophila, fruit fly, genetic similarity, grave, humans, liang zhang, lifecycle, mechanism, michigan state university, molecular details, nontraditional lifestyle, one foot, protein, proteins, retinoblastoma, retinoblastoma proteins, treat cancer, tumor suppressor, wings

Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.

The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.

“Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. “This is an unusual way for proteins to act.” (more…)

Moths Wired Two Ways to Take Advantage of Floral Potluck

By Guest PostDecember 9, 2012Naturearizona, behavior, brain, brain activity, bright green, buffet, caterpillar, channels, chemical composition, favored blossoms, floral environment, flower, hong lei, humans, insects, jeffrey riffell, john hildebrand, leif abrell, manduca sexta, mechanism, moth, naive moths, neural pathways, neurobiology, north, olfactory information, oxygenated aromatic compounds, pollinator, process, scent samples, science express, scientist, sources of nectar, south america, soybean, tobacco hornworms, university, Washington

Moths are able to enjoy a pollinator’s buffet of flowers – in spite of being among the insect world’s picky eaters – because of two distinct “channels” in their brains, scientists at the University of Washington and University of Arizona have discovered.

One olfactory channel governs innate preferences of the palm-sized hawk moths that were studied – insects capable of traveling miles in a single night in search of favored blossoms. The other allows them to learn about alternate sources of nectar when their first choices are not available.

For moths, the ability to seek and remember alternate sources of food helps them survive harsh, food-deprived conditions. Scientists knew bees could learn, but this is the first proof that moths can too. (more…)

New Insights into How Genetic Differences among Individuals Influence Breast Cancer Risk from Low-Dose Radiation

By Guest PostOctober 17, 2012Health, Scienceandy wyrobek, antoine snijders, berkeley lab, breast cancer, cancer risk, cellular, cellular proliferation, chemical therapy, ct scan, department, dna repair, energy, gene, genetic makeup, gland cancer, immune response, ionizing radiation, joe gray, low dose, mammary tissue, mechanism, mice, non radiation, radiotherapy, resistance, risk, scientist, strain, survival outcome, therapy, tissue mechanism, tissue stress, woman

Berkeley Lab research could lead to new ways to ID women who have higher risk of breast cancer from low-dose radiation

Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified tissue mechanisms that may influence a woman’s susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

The research could lead to new ways to identify women who have higher or lower risks of breast cancer from low-dose radiation. Such a predictive tool could help guide the treatment of cancer patients who may be better served by non-radiation therapies. (more…)

Berkeley Lab Scientists Create First 3-D Model of a Protein Critical to Embryo Development

By Guest PostSeptember 21, 2012Science3d model, aebp2, alessio maiolica, angstroms, arm1, arm2, berkeley lab, birth defect, cancer, chromatin environment, claudio ciferri, complex, complex 2, crystal structure, DNA, electron microscopy, eva nogales, franz herzog, function, gabriel lander, human, mass spectrometry, mechanism, model, molecular architecture, nucleosome, polycomb, prc2, progression, protein, protein biochemistry, repressive, ruedi aebersold, therapeutic drug

The first detailed and complete picture of a protein complex that is tied to human birth defects as well as the progression of many forms of cancer has been obtained by an international team of researchers led by scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). Knowing the architecture of this protein, PRC2, for Polycomb Repressive Complex 2, should be a boon to its future use in the development of new and improved therapeutic drugs.

“We present a complete molecular organization of human PRC2 that offers an invaluable structural context for understanding all of the previous biochemical and functional data that has been collected on this complex,” says Berkeley Lab biophysicist Eva Nogales, an electron microscopy expert who led this research. “Our model should also be an invaluable tool for the design of new experiments aimed at asking detailed questions about the mechanisms that enable PRC2 to function and how those mechanisms might be exploited.” (more…)

Employees at ‘Green’ Companies are Significantly more Productive, Study Finds

By Guest PostSeptember 11, 2012Economy, Environmentambrose hotel, beneficial effect, bottom line, certification, company, conventional firm, eco label, economic performance, employee, Environment, environmental commitment, environmental impact, environmentalism, fair trade, firm, france, green certification, green companies, green practice, interpersonal relationship, investor, iso 14001, labor productivity, magali delmas, mechanism, organic, paris dauphine, patagonia, productivity, proxy, revenue, sanja pekovic, santa monica, sustainability, ucla, united states, university, virtuous circle

Bucking the idea that environmentalism hurts economic performance, a new UCLA-led study has found that companies that voluntarily adopt international “green” practices and standards have employees who are 16 percent more productive than the average.

Professor Magali Delmas, an environmental economist at UCLA’s Institute of the Environment and Sustainability and the UCLA Anderson School of Management, and Sanja Pekovic from France’s University Paris–Dauphine are the first to study how a firm’s environmental commitment affects its productivity.

Their findings are published online Sept. 10 in the Journal of Organizational Behavior. (more…)

Plants Unpack Winter Coats When Days Get Shorter

By Guest PostAugust 29, 2012Sciencecbf, cold response pathway, crepeat binding, crop productivity, factor, freezing, freezing temperature, frost protection, gene, mechanism, michael thomashow, plant, potential tool, sunlight

EAST LANSING, Mich. — Mechanisms that protect plants from freezing are placed in storage during the summer and wisely unpacked when days get shorter.

In the current issue of the Proceedings of the National Academy of Sciences, Michael Thomashow, University Distinguished Professor of molecular genetics, demonstrates how the CBF (C-repeat binding factor) cold response pathway is inactive during warmer months when days are long, and how it’s triggered by waning sunlight to prepare plants for freezing temperatures. (more…)

Better Monitoring of Food Quantity Makes Self-Control Easier

By Guest PostAugust 27, 2012Healthamerica, carlson school, consumption, eat less, food quantity, joseph redden, kelly haws, mechanism, minneapolis, monitoring, obesity problem, satiation, self control, st paul, twin cities, university of minnesota

UMN study shows eating less is about reduced desire as well as willpower

MINNEAPOLIS / ST. PAUL — New research from the University of Minnesota’s Carlson School of Management suggests learning how to stop enjoying unhealthy food sooner may play a pivotal role in combating America’s obesity problem. The research, published in the Journal of Consumer Research, explores how satiation, defined as the drop in liking during repeated consumption, can be a positive mechanism when it lowers the desire for unhealthy foods.

“When people talk about self-control, they really imply that self-control is willpower and that some people have it and others don’t when facing a tempting treat,” says Joseph Redden, an assistant professor of marketing at the Carlson School and lead author of the ‘Healthy Satiation: The Role of Decreasing Desire in Effective Self-Control.’ “In reality, nearly everyone likes these treats. Some people just stop enjoying them faster and for them it’s easier to say no.” (more…)