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Clearing a Potential Road Block to Bisabolane

By Guest PostJanuary 14, 2012Scienceabies grandis, abies grandis α bisabolene synthase, advanced biofuels, agbis, andy degiovanni, berkeley lab, biofuel, biosynthetic alternative, bisabolane, ca, chemical compounds, cofactors, d2 diesel fuel, emeryville, enzyme, evolutionary heritage, flavorings, fragrances, grand fir, green energy, inhibitors, jay keasling, jose pereira, masood hadi, microbes, microbial based production, pamela peralta yahya, paul adams, precursor, protein, protein crystal structure, renewable alternative, resolution, ryan mcandrew, synthases in plants, terpene class, terpenoid synthases, three dimensional crystal structure, trucking industry, united states, x ray crystallography

*Joint BioEnergy Institute Researchers Identify Key Enzyme Structure*

The recent discovery that bisabolane, a member of the terpene class of chemical compounds used in fragrances and flavorings, holds high promise as a biosynthetic alternative to D2 diesel fuel has generated keen interest in the green energy community and the trucking industry. Now a second team of researchers with the U.S Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) has determined the three-dimensional crystal structure of a protein that is key to boosting the microbial-based production of bisabolane as an advanced biofuel.

The JBEI research team, led by bioengineers Paul Adams and Jay Keasling, solved the protein crystal structure of an enzyme in the Grand fir (Abies grandis) that synthesizes bisabolene, the immediate terpene precursor to bisabolane. The performance of this enzyme – the Abies grandis α-bisabolene synthase (AgBIS) – when engineered into microbes, has resulted in a bottleneck that hampers the conversion by the microbes of simple sugars into bisabolene. (more…)

MU Researchers Find Unique Protein Organization in Arteries Associated with Cardiovascular Disease

By Guest PostJanuary 13, 2012Health, Science3 d microscopic imaging technology, amount of protein, artery, artery functions, blood vessels, cardiovascular disease, cause of death, circulatory complications, diabetes, disorders, elastin, elastin production, factor, gerald meininger, high blood pressure, human arteries, michael hill, minute structural elements, molecular biologists, stiffening, stiffening process, tissue replacement proces, united states, university of missouri

*Knowledge could assist in tissue replacements, treatments for high blood pressure and diabetes*

COLUMBIA, Mo. – Human arteries – some smaller than a strand of hair – stiffen as a person ages. This stiffening is a factor in cardiovascular disease, the leading cause of death in the United States, because it contributes to the circulatory complications in disorders such as high blood pressure and diabetes. University of Missouri researchers have now used advanced 3-D microscopic imaging technology to identify and monitor the proteins involved in this stiffening process. These findings could eventually help researchers and physicians understand and treat complications associated with cardiovascular disease. (more…)

Stars Pop Onto the Scene in New WISE Image

By Guest PostJanuary 13, 2012Scienceamerican astronomical society, astronomers, bubbles, cosmic clouds, dave leisawitz, gas and dust, milky way galaxy, mosaic, NASA, natal clouds, nebulae, new star birth, newborn stars, public astronomy, radiation, space telescope, specimens, star formation, star forming clouds, triggered star formation, triggered star formation theory, wide field infrared survey explorer, wise, wise mosaic, xavier koenig

PASADENA, Calif. — A new, large mosaic from NASA’s Wide-Field Infrared Survey Explorer (WISE) showcases a vast stretch of cosmic clouds bubbling with new star birth. The region — a 1,000-square-degree chunk of our Milky Way galaxy — is home to numerous star-forming clouds, where massive stars have blown out bubbles in the gas and dust.

“Massive stars sweep up and destroy their natal clouds, but they continuously spark new stars to form along the way,” said WISE Mission Scientist Dave Leisawitz of NASA Goddard Space Flight Center, Greenbelt, Md. Leisawitz is co-author of a new paper reporting the results in the Astrophysical Journal. “Occasionally a new, massive star forms, perpetuating the sequence of events and giving rise to the dazzling fireworks display seen in this WISE mosaic.” (more…)

NASA Radar to Study Hawaii’s Most Active Volcano

By Guest PostJanuary 12, 2012Scienceactive volcano, airborne radar, big island, deformation, dryden flight research center, earth surface, east rift zone, edwards, hawaii, interferometry, jet propulsion laboratory, kilauea volcano, NASA, pasadena, pulses of microwave energy, research aircraft, sensor, uavsar, uninhabited aerial vehicle synthetic aperture radar

An airborne radar developed by NASA’s Jet Propulsion Laboratory, Pasadena, Calif., has returned to Hawaii to continue its study of Kilauea volcano, Hawaii’s current most active volcano.

The Uninhabited Aerial Vehicle Synthetic Aperture Radar, or UAVSAR, mounted in a pod under NASA’s G-III research aircraft from NASA’s Dryden Flight Research Center, Edwards, Calif., returned to Hawaii’s Big Island on Jan. 7. The one-week airborne campaign will help scientists better understand processes occurring under Earth’s surface at Kilauea. (more…)

Evolution is Written All Over Your Face

By Guest PostJanuary 11, 2012Scienceevolution, evolutionary detectives, faces of primates, facial expressions, facial features, new world primates, shaping human faces

Why are the faces of primates so dramatically different from one another?

UCLA biologists working as “evolutionary detectives” studied the faces of 129 adult male primates from Central and South America, and they offer some answers in research published today, Jan. 11, in the early online edition of the journal Proceedings of the Royal Society B. The faces they studied evolved over at least 24 million years, they report. (more…)

Scientists Look to Microbes to Unlock Earth’s Deep Secrets

By Guest PostJanuary 11, 2012Sciencebasalt core samples, igneous ocean crust, ocean sediments, subseafloor

To find answers, oceanographers install observatories beneath remote seafloor

Of all the habitable parts of our planet, one ecosystem still remains largely unexplored and unknown to science: the igneous ocean crust. (more…)

Cosmetic Chemical Hinders Brain Development in Tadpoles

By Guest PostJanuary 11, 2012Sciencechemical preservative, cosmetic chemical, negative effects, neural development, neural function

A new study finds that low concentrations of the chemical methylisothiazolinone has subtle but measurable negative effects on the neural development of tadpoles. The chemical is found in some cosmetics, although the study does not provide any evidence that cosmetics are unsafe for humans. (more…)

The Next Big Step Toward Atom-Specific Dynamical Chemistry

By Guest PostJanuary 8, 2012Science2p orbitals, 2s orbitals, advanced light source, ali belkacem, america, atomic levels, atoms, berkeley lab, chemical bonding, chemical energy, chemistry, complex systems, components, electrical conductivity, electron, electronic spectroscopy, electronic states of neon, emergence, energy flow in photosynthesis, evolution of energy, fels, femtoseconds, free electron lasers, graham fleming, harmonics, high frequency x rays, molecular level, molecules, nonlinear, nonlinear multidimensional spectroscopy, nonlinear spectroscopic technique, orbitals, photon flux, positive charge, pulse, quadrillionths of second, s orbitals, spectroscopy, stimulated coherent raman scattering, sunlight energy, synchrotron light sources, table top laser, ultraviolet light, valence electrons, valence shell, x ray lasers, x ray photon, x ray spectroscopy, x-rays

*Berkeley Lab scientists push chemistry to the edge, testing plans for a new generation of light sources*

For Ali Belkacem of Berkeley Lab’s Chemical Sciences Division, “What is chemistry?” is not a rhetorical question.

“Chemistry is inherently dynamical,” he answers. “That means, to make inroads in understanding – and ultimately control – we have to understand how atoms combine to form molecules; how electrons and nuclei couple; how molecules interact, react, and transform; how electrical charges flow; and how different forms of energy move within a molecule or across molecular boundaries.” The list ends with a final and most important question: “How do all these things behave in a correlated way, ‘dynamically’ in time and space, both at the electron and atomic levels?” (more…)

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