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New Details on the Molecular Machinery of Cancer

By Guest PostFebruary 17, 2013Scienceactivation, adam smith, addition of phosphate, anton arkhipov, autophosphorylation, berkeley lab, cancer, cancer therapies, cancers, cell surface protein, cellular functions, computational modeling, egf ligand, egfr, epidermal growth factor, fluorescence spectroscopy, gene, immune system, jay groves, john kuriyan, ligand induced dimerization, living cells, molecular machinery, nicholas endres, nuclear magnetic resonance, photon, post translational process, protein activation, quantitative approach, quantitative biology techniques, rahul das, receptor, receptor tyrosine kinases, single compound molecule, specific proteins, t-cell receptors, time resolved, uc, university of california

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)

Russia Meteor Not Linked to Asteroid Flyby

By Guest PostFebruary 16, 2013Sciencealaska, asteroid flyby, atmosphere, canada, chelyabinsk, earth, infrasound data, jet propulsion laboratory, kilotons, NASA, network of sensors, object, pasadena, paul chodas, peter brown, russia, russia meteor, size, trajectory, university, western ontario

New information provided by a worldwide network of sensors has allowed scientists to refine their estimates for the size of the object that entered that atmosphere and disintegrated in the skies over Chelyabinsk, Russia, at 7:20:26 p.m. PST, or 10:20:26 p.m. EST on Feb. 14 (3:20:26 UTC on Feb. 15).

The estimated size of the object, prior to entering Earth’s atmosphere, has been revised upward from 49 feet (15 meters) to 55 feet (17 meters), and its estimated mass has increased from 7,000 to 10,000 tons. Also, the estimate for energy released during the event has increased by 30 kilotons to nearly 500 kilotons of energy released. These new estimates were generated using new data that had been collected by five additional infrasound stations located around the world – the first recording of the event being in Alaska, over 6,500 kilometers away from Chelyabinsk. The infrasound data indicates that the event, from atmospheric entry to the meteor’s airborne disintegration took 32.5 seconds. The calculations using the infrasound data were performed by Peter Brown at the University of Western Ontario, Canada. (more…)

Earthquakes, Glue and Grappling Hooks: Scientists Dissect the Movement of Bacteria

By Guest PostFebruary 15, 2013Scienceanti infective, avalanche motions, california nanosystems institute, combat harmful microbes, combat microbial pathogenesis, earthquakes, frequency, fruiting body, gerard wong, glide along surface, glue, grappling hooks, henry samueli school, human tissue, intensity, karin a dahmen, max gibiansky, microscopic bacteria, molecular glue, molecular mechanism, movement of bacteria, myxococcus xanthus, pathogenic bacteria, social structures, tectonic plates, tectonic plates move, therapeutic strategies, ucla, university of Illinois, urbana-champaign, wei hu, wenyuan shi

A team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has discovered that microscopic bacteria have a lot in common with earthquakes — when it comes to their jolting movements.

In a new study published in the peer-reviewed Proceedings of the National Academy of Sciences, the scientists also report that a molecular “glue” produced by the bacteria to help them adhere to surfaces also acts as a sort of transportation lubricant, helping them move and organize into rudimentary social structures. These discoveries, they say, could lead to new ways to combat harmful microbes in the long term. (more…)

UA Scientists Help Discover Most Abundant Ocean Virus

By Guest PostFebruary 14, 2013Scienceocean living bacterium, ocean virus, pelagiphages viruses

Researchers have discovered four previously unknown viruses that infect the Earth’s most abundant organism, the marine bacterium SAR11. Because of their huge numbers, these tiny players have critical roles in the global cycle of carbon and other nutrients

The greatest battle in Earth’s history has been going on for hundreds of millions of years, isn’t over yet, and until now no one knew it existed, scientists reported today in the journal Nature. (more…)

NASA Satellites Find Freshwater Losses in Middle East

By Guest PostFebruary 14, 2013Scienceamount of water, austin, basin, data, dead sea, drought, euphrates river, geosciences, german aerospace center, german research center, goddard, grace data, greenbelt, ground based data, hydrologic observations, hydrological modeling, international laws, iran, Iraq, irvine, jay famiglietti, lost freshwater reserves, matt rodell, middle east region, nasa satellites, pumping of groundwater, satellite data, space flight center, stakeholders, syria, tigris, turkey, underground reservoirs, united states, university of california, university of texas, water management

PASADENA, Calif. – A new study using data from a pair of gravity-measuring NASA satellites finds that large parts of the arid Middle East region lost freshwater reserves rapidly during the past decade.

Scientists at the University of California, Irvine; NASA’s Goddard Space Flight Center in Greenbelt, Md.; and the National Center for Atmospheric Research in Boulder, Colo., found during a seven-year period beginning in 2003 that parts of Turkey, Syria, Iraq and Iran along the Tigris and Euphrates river basins lost 117 million acre feet (144 cubic kilometers) of total stored freshwater. That is almost the amount of water in the Dead Sea. The researchers attribute about 60 percent of the loss to pumping of groundwater from underground reservoirs. (more…)

African Chickens

By Guest PostFebruary 13, 2013Scienceafrican chicken dna, african chickens, american chickens, chickens in kenya, disease resistance, production facility chicken

UD’s Schmidt studies heat stress, disease resistance in African chickens

Last fall, the University of Delaware’s Carl Schmidt took a trip to Uganda with a team of researchers from Iowa State University and North Carolina State University to get genetic samples from African chickens. The goal was to compare and contrast their genes to one another, and also to American broiler chickens, to gauge how the two species’ genetic makeup helps them cope with heat stress, as well as susceptibility and resistance to different diseases. (more…)

Bisphenol A Affects Sex-Specific Reproductive Behaviors in a Monogamous Animal Species, Says MU Researcher

By Guest PostFebruary 13, 2013Environment, Health, Scienceaggression, american public, anxiety, assess, beer, behavioral effects, behaviors of males, bisphenol a, boys versus girls, bpa, california mouse, canned goods, chemical exposure, cheryl rosenfeld, david geary, denise warzak, eldin jasarevic, female hormones, females, gregory vandas, human body, human societies, mark ellersieck, monogamous rodent, nutritional support, offspring, paper receipts, peromyscus californicus, plastic containers, post natal exposure, pre, r michael roberts, reproductive associated behaviors, researchers, risk to children, rodents, rosenfelds lab, scott williams, sex specific, soda cans, species, university of missouri

Animal Findings Suggest That Gender May Also Influence Chemical Exposure Risks for Humans

COLUMBIA, Mo. — Parents, teachers and psychologists know boys and girls behave differently. However, that difference isn’t taken into account by most methods used to assess the risk to children from chemical exposure, according to Cheryl Rosenfeld, associate professor of biomedical sciences in the University of Missouri’s Bond Life Sciences Center. A series of experiments by Rosenfeld studied the effects of prenatal exposure to bisphenol A (BPA) on later reproductive-associated behaviors using a socially and genetically monogamous rodent, the California mouse, which may better mirror most human societies than other rodents. (more…)

Mars Rock Takes Unusual Form

By Guest PostFebruary 12, 2013Sciencecuriosity mars rover, earth, erosion, mars, mars rock, martian rock, mast camera, mastcam, metallic object, NASA, natural elements, ronald sletten, seattle, shiny appearance, shiny looking rock, similar phenomena, types of rocks, university of washington, unusual appearance, unusual form

On Mars, as on Earth, sometimes things can take on an unusual appearance. A case in point is a shiny-looking rock seen in a recent image from NASA’s Curiosity Mars rover.

Some casual observers might see a resemblance to a car door handle, hood ornament or some other type of metallic object. To Ronald Sletten of the University of Washington, Seattle, a collaborator on Curiosity’s science team, the object is an interesting study in how wind and the natural elements cause erosion and other effects on various types of rocks. (more…)

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