Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed a new screening approach to identify chemical compounds that can target and kill the stem cells responsible for creating deadly brain tumors.
Glioblastoma is one of the deadliest malignancies, typically killing patients within 12 to 18 months. These brain cancers consist of two kinds of cells: a larger, heterogeneous population of tumor cells and a smaller sub-population of stem cells, which are treatment-resistant. (more…)
*MU study finds disordered eating combined with heavy drinking is common among college students*
COLUMBIA, Mo. – It is well known that eating disorders are common among teens and college students. Heavy alcohol consumption is another well-known unhealthy habit of this age group. A new study from the University of Missouri shows that when college students combine these two unhealthy habits, their long-term health may be affected. “Drunkorexia” is a new term coined by the media to describe the combination of disordered eating and heavy alcohol consumption.
Victoria Osborne, assistant professor of social work and public health, examined the relationship between alcohol misuse and disordered eating, including calorie restriction and purging. Researchers found that 16 percent of those surveyed reported restricting calories to “save them” for drinking. Of the respondents, about three times as many women reported engaging in the behavior than men. Motivations for “drunkorexia” include preventing weight gain, getting intoxicated faster and saving money that would be spent on food to buy alcohol. (more…)
The Woods Hole Oceanographic Institution (WHOI) has signed a $1.18 million agreement with the Flatley Discovery Lab in Charlestown, Mass., to investigate and supply marine microbial extracts as possible treatments for cystic fibrosis (CF).
The life-shortening respiratory disease has eluded attempts at a cure, although researchers have been successful in some cases at adding years to a person’s lifespan, primarily through treatment with antibiotics. (more…)
*Research gives insight into 50-year-old mystery – zinc important for learning and memory
TORONTO, ON – Zinc plays a critical role in regulating how neurons communicate with one another, and could affect how memories form and how we learn. The new research, in the current issue of Neuron, was authored by Xiao-an Zhang, now a chemistry professor at the University of Toronto Scarborough (UTSC), and colleagues at MIT and Duke University.
Researchers have been trying to pin down the role of zinc in the brain for more than fifty years, ever since scientists found high concentrations of the chemical in synaptic vesicles, a portion of the neuron that stores neurotransmitters. But it was hard to determine just what zinc’s function was. (more…)
Data shows Correlation between New Therapeutic Approach, Viral Load Reduction
Data from a clinical trial involving UCLA researchers suggest that a new therapy may potentially serve as a “functional cure” for HIV/AIDS.
The therapy, called SB-728-T, involves the modification of both copies of a patient’s CCR5 gene, which encodes the major co-receptor used by HIV to infect immune system cells.
In the Sangamo BioSciences’ phase 1 trial, SB-728-T was given to HIV patients who were on highly active antiretroviral therapy (HAART) but were considered to be “non-responders” — that is, their CD4+ T-cell levels, a key measure of immune system health, remained low. The patients’ HAART therapy was interrupted when they received the SB-728-T therapy. (more…)
AUSTIN, Texas — Chagas disease, a tropical parasitic disease that can lead to life-threatening heart and digestive disorders, may be more widespread in Texas than previously thought, according to research from The University of Texas at Austin.
“We’ve been studying this for four years now, and this year the number of disease-causing insects is quite amazing,” says Sahotra Sarkar, professor of integrative biology and philosophy at The University of Texas at Austin and lead author of a paper on the disease published in PLoS Neglected Tropical Diseases. (more…)
The brain learns through changes in the strength of its synapses — the connections between neurons — in response to stimuli.
Now, in a discovery that challenges conventional wisdom on the brain mechanisms of learning, UCLA neuro-physicists have found there is an optimal brain “rhythm,” or frequency, for changing synaptic strength. And further, like stations on a radio dial, each synapse is tuned to a different optimal frequency for learning.
The findings, which provide a grand-unified theory of the mechanisms that underlie learning in the brain, may lead to possible new therapies for treating learning disabilities. (more…)
The latest results from an expedition to Mount Everest that looked at the body’s response to low oxygen levels suggest that drugs or procedures that promote the body’s production of a chemical compound called nitric oxide (NO) could improve the recovery of critically ill patients in intensive care.
Many critically ill patients suffer from a shortage of oxygen (a condition known as ‘hypoxia’), which can be life-threatening. NO is produced by virtually every cell and organ in the body where it serves many important functions including the regulation of blood pressure, learning and memory formation, and protecting us from infectious diseases. (more…)
