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New Details on the Molecular Machinery of Cancer

By Guest PostFebruary 17, 2013Scienceactivation, adam smith, addition of phosphate, anton arkhipov, autophosphorylation, berkeley lab, cancer, cancer therapies, cancers, cell surface protein, cellular functions, computational modeling, egf ligand, egfr, epidermal growth factor, fluorescence spectroscopy, gene, immune system, jay groves, john kuriyan, ligand induced dimerization, living cells, molecular machinery, nicholas endres, nuclear magnetic resonance, photon, post translational process, protein activation, quantitative approach, quantitative biology techniques, rahul das, receptor, receptor tyrosine kinases, single compound molecule, specific proteins, t-cell receptors, time resolved, uc, university of california

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)

Golden Potential for Gold Thin Films

By Guest PostApril 29, 2012Science1d chain, 2d nanoparticle, 2d sheet, berkeley lab, block, catalysis, co polymer, DNA, gold nanoparticle, joseph kao, microdomain, microtechnology, nanometer, nanoparticle, peter bai, peter ercius, plasmonic metamaterial, plasmonic technology, polymer scientist, polymer supramolecule, scalable nanomanufacturing, semiconductor nanocrystal, solvent evaporation, supramolecular nanocomposites, thin film, three dimensional array, ting xu, uc, university of california, vivian chuang, zhang jiang

Berkeley Lab Researchers Direct the Self-Assembly of Gold Nanoparticles into Device-Ready Thin films

Scientists with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have directed the first self-assembly of nanoparticles into device-ready materials. Through a relatively easy and inexpensive technique based on blending nanoparticles with block co-polymer supramolecules, the researchers produced multiple-layers of thin films from highly ordered one-, two- and three-dimensional arrays of gold nanoparticles. Thin films such as these have potential applications for a wide range of fields, including computer memory storage, energy harvesting, energy storage, remote-sensing, catalysis, light management and the emerging new field of plasmonics.

“We’ve demonstrated a simple yet versatile supramolecular approach to control the 3-D spatial organization of nanoparticles with single particle precision over macroscopic distances in thin films,” says polymer scientist Ting Xu, who led this research. “While the thin gold films we made were wafer-sized, the technique can easily produce much larger films, and it can be used on nanoparticles of many other materials besides gold.” (more…)

The Brittleness of Aging Bones – More than a Loss of Bone Mass

By Guest PostSeptember 3, 2011Scienceadvanced light source, age related structural changes in human cortical bone, als, berkeley lab, biological aging, björn busse, bone strength and fracture toughness, bones, brittle, calcium, collagen molecules, concentric rings of lamellae plates, department of energy, doe, elizabeth zimmermann, eric schaible, fracturing, ha, holly barth, hrishikesh bale, human cortical or compact bone, hydroxyapatite, joel ager, lawrence berkeley national laboratory, loss of mass, macroscopic fracture testing, molecular level, nanocrystals, nanoscale, older bones fracturing, peter reichert, robert ritchie, simon tang, tamara alliston, uc, university of california, young human bone

*Berkeley Lab Researchers Show How Loss of Bone Quality Also a Major Factor*

It is a well-established fact that as we grow older our bones become more brittle and prone to fracturing. It is also well established that loss of mass is a major reason for older bones fracturing more readily than younger bones, hence medical treatments have focused on slowing down this loss. However, new research from scientists at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) shows that at microscopic dimensions, the age-related loss of bone quality can be every bit as important as the loss of quantity in the susceptibility of bone to fracturing. (more…)

Tag Archives: uc

New Details on the Molecular Machinery of Cancer

Golden Potential for Gold Thin Films

The Brittleness of Aging Bones – More than a Loss of Bone Mass