Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.
“Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. “This is an unusual way for proteins to act.” (more…)
Moths are able to enjoy a pollinator’s buffet of flowers – in spite of being among the insect world’s picky eaters – because of two distinct “channels” in their brains, scientists at the University of Washington and University of Arizona have discovered.
One olfactory channel governs innate preferences of the palm-sized hawk moths that were studied – insects capable of traveling miles in a single night in search of favored blossoms. The other allows them to learn about alternate sources of nectar when their first choices are not available.
For moths, the ability to seek and remember alternate sources of food helps them survive harsh, food-deprived conditions. Scientists knew bees could learn, but this is the first proof that moths can too. (more…)
COLUMBIA, Mo. — Approximately 250,000 people in the United States suffer from muscular dystrophy, which occurs when damaged muscle tissue is replaced with fibrous, bony or fatty tissue and loses function. Three years ago, University of Missouri scientists found a molecular compound that is vital to curing the disease, but they didn’t know how to make the compound bind to the muscle cells. In a new study, published in the Proceedings of the National Academies of Science, MU School of Medicine scientists Yi Lai and Dongsheng Duan have discovered the missing pieces to this puzzle that could ultimately lead to a therapy and, potentially, a longer lifespan for patients suffering from the disease.
Duchenne muscular dystrophy (DMD), predominantly affecting males, is the most common type of muscular dystrophy. Patients with Duchenne muscular dystrophy have a gene mutation that disrupts the production of dystrophin, a protein essential for muscle cell survival and function. Absence of dystrophin starts a chain reaction that eventually leads to muscle cell degeneration and death. While dystrophin is vital for muscle development, the protein also needs several “helpers” to maintain the muscle tissue. One of these “helper” molecular compounds is nNOS, which produces nitric oxide that can keep muscle cells healthy after exercise. (more…)
The U is at the forefront of cancer research in dogs
After more than an hour discussing the shared evolution of dogs and humans, and how the cancer mysteries that lie deep within one may inform and effect treatments on the other, U researcher Jaime Modiano smiles and says, “I love my job.”
And why not?
He’s at the forefront of an array of exciting research that stands to improve the health of both dogs and people.(more…)
A new study in the journal Neuron suggests that the brain uses a different region than neuroscientists had thought to associate objects and locations in the space around an individual. Knowing where this fundamental process occurs could help treat disease and brain injury as well as inform basic understanding of how the brain supports memory and guides behavior.
PROVIDENCE, R.I. [Brown University] — Where are you?
Conventional wisdom in brain research says that you just used your hippocampus to answer that question, but that might not be the whole story. The context of place depends on not just how you got there, but also the things you see around you. A new study in Neuron provides evidence that a different part of the brain is important for understanding where you are based on the spatial layout of the objects in that place. The finding, in rats, has a direct analogy to primate neuroanatomy. (more…)
People are able to detect, within a split second, if a hurtful action they are witnessing is intentional or accidental, new research on the brain at the University of Chicago shows.
The study is the first to explain how the brain is hard-wired to recognize when another person is being intentionally harmed. It also provides new insights into how such recognition is connected with emotion and morality, said lead author Jean Decety, the Irving B. Harris Professor of Psychology and Psychiatry at UChicago. (more…)
GAINESVILLE, Fla. — Rats and humans have at least one thing in common: They both react the same way to a placebo, according to a new University of Florida study.
“That was the big finding — that the animals that expected pain relief actually got pain relief when you gave them an inert substance,” said co-author John Neubert, a pain specialist and an associate professor with the UF College of Dentistry department of orthodontics. “It helps validate our model that what we do in the rats, we believe, is a good representation of what’s being seen in humans.”
The investigation of placebo effects might lead to the identification of new therapeutic targets in the brain and of novel treatment strategies for a variety of health conditions. (more…)
Developing a shared sense of global community could help reduce major episodes of violence
In the tribal societies of the Amazon forest, violent conflict accounted for 30 percent of all deaths before contact with Europeans, according to a recent study by University of Missouri anthropologist Robert Walker. Understanding the reasons behind those altercations in the Amazon sheds light on the instinctual motivations that continue to drive human groups to violence, as well as the ways culture influences the intensity and frequency of violence.
“The same reasons – revenge, honor, territory and jealousy over women – that fueled deadly conflicts in the Amazon continue to drive violence in today’s world,” said Walker, lead author and assistant professor of anthropology in MU’s College of Arts and Science. “Humans’ evolutionary history of violent conflict among rival groups goes back to our primate ancestors. It takes a great deal of social training and institutional control to resist our instincts and solve disputes with words instead of weapons. Fortunately, people have developed ways to channel those instincts away from actual deadly conflict. For example, sports and video games often involve the same impulses to defeat a rival group.” (more…)
