Category Archives: Science

Smarter Toxins Help Crops Fight Resistant Pests

*A slight change in molecular structure introduced by genetic engineering gives crop-protecting proteins called Bt toxins a new edge in overcoming resistance of certain pests, a UA-led team of researchers reports in Nature Biotechnology.*

One of the most successful strategies in pest control is to endow crop plants with genes from the bacterium Bacillus thuringiensis, or Bt for short, which code for proteins that kill pests attempting to eat them.

But insect pests are evolving resistance to Bt toxins, which threatens the continued success of this approach. In the current issue of Nature Biotechnology, a research team led by UA Professor Bruce Tabashnik reports the discovery that a small modification of the toxins’ structure overcomes the defenses of some major pests that are resistant to the natural, unmodified Bt toxins. (more…)

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Charles P. Sonett: the Legacy of a Pioneering Space Scientist

Charles P. Sonett, the first head of the UA’s department of planetary sciences, died at the age of 87. Sonett was involved in spacecraft missions that dramatically advanced our understanding of the solar system and beyond, including the Pioneer Program, the Explorer Program and the Apollo Program

Charles “Chuck” P. Sonett, a founding faculty member and the first department head of the University of Arizona’s department of planetary sciences, died on Sept. 30. He was 87. (more…)

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How the Brain Makes Memories: Rhythmically!

The brain learns through changes in the strength of its synapses — the connections between neurons — in response to stimuli.

Now, in a discovery that challenges conventional wisdom on the brain mechanisms of learning, UCLA neuro-physicists have found there is an optimal brain “rhythm,” or frequency, for changing synaptic strength. And further, like stations on a radio dial, each synapse is tuned to a different optimal frequency for learning.

The findings, which provide a grand-unified theory of the mechanisms that underlie learning in the brain, may lead to possible new therapies for treating learning disabilities. (more…)

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UA Alumnus Wins Nobel Prize

Brian P. Schmidt, who graduated from the UA in 1989 with a double major in astronomy and physics, shares this year’s Nobel Prize in Physics with two colleagues for a discovery that has rocked our understanding of the cosmos: The universe is expanding at an ever-faster pace.

In the last years of the 20th century, two teams of researchers set out to race each other to measure the rate of the universe’s expansion, and by extension, unveil how the universe most likely will end. (more…)

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UCLA Study Shows Cell-Penetrating Peptides for Drug Delivery Act Like A Swiss Army Knife

Cell-penetrating peptides, such as the HIV TAT peptide, are able to enter cells using a number of mechanisms, from direct entry to endocytosis, a process by which cells internalize molecules by engulfing them.

Further, these cell-penetrating peptides, or CPPs, can facilitate the cellular transfer of various molecular cargoes, from small chemical molecules to nano-sized particles and large fragments of DNA. Because of this ability, CPPs hold great potential as in vitro and in vivo delivery vehicles for use in research and for the targeted delivery of therapeutics to individual cells. (more…)

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