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UD researchers develop novel technique for early detection of misfolded protein

University of Delaware assistant professor David W. Colby is co-author of a paper in the March 23 issue of the Journal of Biological Chemistry that suggests protein misfolding may occur early in the pathogenesis, or development, of Huntington’s disease.

Huntington’s disease (HD) is one of several neurological diseases, such as Alzheimer’s disease or prion disease, associated with proteins that fold into abnormal structures. HD is characterized by progressive motor impairment, cognitive decline and behavioral abnormalities, and ultimately death. (more…)

Scientists Develop Technology Revolutionizing Single-Cell Studies

By Guest PostOctober 28, 2011Sciencearchaea, bacteria in the human body, bacterial infections, bacterial pathogenesis, deep sea, global gene expression, j craig venter institute, laser tweezers system, microarrays, microbial cells lacking a nucleus, novel technology, prokaryotes, rna seq, rna sequencing, single bacterium, single cell transcriptomics, snyder hall laboratory, stuart p donachie, tung t hoang, university of hawaii at manoa, yun kang

Researchers at the University of Hawaiʻi at Mānoa, in collaboration with scientists at the J. Craig Venter Institute, have made a significant breakthrough in developing a novel technology to investigate global gene-expression in a single bacterium. The team, led by Associate Professors Tung T. Hoang and Stuart P. Donachie, recently published a paper describing the technology in Genome Research (21:925-935), a premier international genome journal. UH Mānoa postdoctoral researcher Dr. Yun Kang, who performed this research in a Snyder Hall laboratory, contributed significantly and worked diligently to overcome the numerous technical challenges presented. (more…)

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Huntington’s Disease

Scientists Develop Technology Revolutionizing Single-Cell Studies