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Protein ‘Jailbreak’ Helps Cancer Cells Live

By Guest PostMarch 28, 2012Healthbetter therapies, breast cancer cell, cancer cells alive

Researchers at Brown University and Hasbro Children’s Hospital have traced the molecular interactions that allow the protein survivin to escape the nucleus of a breast cancer cell and prolong the cell’s life. The study may help in the development of better therapies and prognostics

PROVIDENCE, R.I. [Brown University] — If the fight against breast cancer were a criminal investigation, then the proteins survivin, HDAC6, CBP, and CRM1 would be among the shadier figures. In that vein, a study to be published in the March 30 Journal of Biological Chemistry is the police report that reveals a key moment for keeping cancer cells alive: survivin’s jailbreak from the nucleus, aided and abetted by the other proteins. The research highlights that a protein’s location in a cell affects its impact on disease, and offers clear new leads for the investigation. (more…)

The Gene That Can Transform Mild Influenza in to a Life Threatening Disease

By Guest PostMarch 26, 2012Health, Scienceantiviral, cell, deenan pillay, disease, gene variant, genetic finding, greg towers, h1n1 pandemic influenza, hiv, ifitm3 gene, infection, influenza, life threatening, paul kellam, protein, sir mark walport, swine flu, ucl, variant, virus infection

A genetic finding could help to explain why influenza becomes a life-threatening disease for some people, and yet has only a mild effect on others. Collaborative research led by scientists at UCL and the Wellcome Trust Sanger Institute found that people who carry a particular variant of the IFITM3 gene are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants.

The gene plays a critical role in protecting the body against infection with influenza and a rare version of it appears to make people more susceptible to severe forms of the disease. The results are published in the journal Nature. (more…)

‘Bed-of-Nails’ Breast Implant Deters Cancer Cells

By Guest PostMarch 26, 2012Healthbed of nails, blood vessel, breast cancer, brown university, cancer tumor, cell, cell function, chemical analysis, electron spectroscopy, lijuan zhang, malignant, michael platek, nanoscale, Nanotechnology, plga, protein, regrowth, thomas webster, tumor, united states, university of rhode island, vegf

Researchers at Brown University have created an implant that appears to deter breast cancer cell regrowth. Made from a common federally approved polymer, the implant is the first to be modified at the nanoscale in a way that causes a reduction in the blood-vessel architecture that breast cancer tumors depend upon, while also attracting healthy breast cells. Results are published in Nanotechnology.

PROVIDENCE, R.I. [Brown University] — One in eight women in the United States will develop breast cancer. Of those, many will undergo surgery to remove the tumor and will require some kind of breast reconstruction afterward, often involving implants. Cancer is an elusive target, though, and malignant cells return for as many as one-fifth of women originally diagnosed, according to the American Cancer Society. (more…)

Walk of A Lifetime Promotes Organ Donation

By Guest PostMarch 21, 2012General, Health, Mediafirefighter, harry kiernan, kidney, liver, los angeles, new haven, new york, organ donation, sukru emre, united states, vietnam veteran, walk of 2012

Donating part of his liver and a kidney to two different recipients was not enough for Harry Kiernan. The Vietnam veteran and firefighter is now taking his efforts to raise awareness about organ donation many steps further by walking across the United States.

Kiernan’s 3,300-mile journey began on March 19 at Yale-New Haven Hospital, where a kick off ceremony for “Walk of 2012,” took place under the Donate Life flag near the hospital’s entrance. (more…)

Cell Phone Use in Pregnancy May Cause Behavioral Disorders in Offspring

By Guest PostMarch 19, 2012Healthcell phone use, cellular telephones, development of offspring, hyperactivity, pregnancy, radiofrequency radiation

Exposure to radiation from cell phones during pregnancy affects the brain development of offspring, potentially leading to hyperactivity, Yale School of Medicine researchers have determined. (more…)

Cancer Genes Differ in Different Parts of a Tumour

By Guest PostMarch 17, 2012Health, Sciencebiomarkers, biopsies, biopsy, cancer cell, cancer treatment, charles swanton, gene faults, genetic fault, genetic landscape, genetic variation, genome, genome sequencing technology, james larkin, kidney cancer, kidney tumours, lesley walker, molecular change, mutation, primary tumour, subtype, theory, tree of life, tumour, ubiquitous mutations

Taking a sample from just one part of a tumour may not give a full picture of its‘genetic landscape’, according to a study published in the New England Journal of Medicine.

The findings could help explain why attempts at using single biopsies to identify biomarkers to which personalised cancer treatments can be targeted have not been more successful. (more…)

New Labor-Tracking Tool Proposed To Reduce C-Sections in First-Time Moms

By Guest PostMarch 16, 2012Healthabortions, c sections, cervix, cesarean, childbirth, dystocia, dystocia diagnosis, emily caldwell, gray area, hormonal intervention, jeremy neal, labor, labor assessment, labor tracking tool, linear process, nancy lowe, oxytocin, painful scarring, partograph, pregnant women, stillbirths, united states

COLUMBUS, Ohio – Researchers have designed a new version of a labor-tracking tool for pregnant women that they predict could reduce the use of hormonal intervention during labor and lower the number of cesarean sections performed on low-risk, first-time mothers.

The tool, called a partograph, takes into account the most recent research findings that suggest labor is not a linear process, but is instead slower during earlier labor and accelerates gradually as labor advances. A diagnosis of abnormally slow labor is the No. 1 reason that C-sections are performed in low-risk births by first-time moms. (more…)

Very Few Low-Income Moms Meet Breastfeeding Recommendations

By Guest PostMarch 16, 2012Healthawareness, awareness of breastfeeding, breastfeeding, low income moms

EAST LANSING, Mich. — Less than 2 percent of low-income mothers met breastfeeding recommendations in a recent study – a drastic decline compared with a more affluent population – and a lack of support and available resources appears to play a key role. (more…)

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