Tag Archives: university of washington

Building Molecular ‘Cages’ to Fight Disease

By Guest PostJune 9, 2012Scienceartificial vaccines, bioinformatics, biomedical engineering, building blocks, circulation, david baker, drug, drug delivery, duilio cascio, human like proteins, lego blocks, medicine, michael sawaya, molecular biology, molecular cages, molecular structure, nanoscale materials, neil king, puzzle pieces, specialized proteins, tangles of ribbon, three-dimensional, tiny structures, todd yeates, traditional vaccine, tumor cells, ucla, university of washington, virus derived proteins, yen ting lai

UCLA-created nanoscale protein containers could aid drug, vaccine delivery

UCLA biochemists have designed specialized proteins that assemble themselves to form tiny molecular cages hundreds of times smaller than a single cell. The creation of these miniature structures may be the first step toward developing new methods of drug delivery or even designing artificial vaccines.

“This is the first decisive demonstration of an approach that can be used to combine protein molecules together to create a whole array of nanoscale materials,” said Todd Yeates, a UCLA professor of chemistry and biochemistry and a member of the UCLA–DOE Institute of Genomics and Proteomics and the California NanoSystems Institute at UCLA. (more…)

Landslides Linked to Plate Tectonics Create the Steepest Mountain Terrain

By Guest PostJune 3, 2012Environmentangle of slope, bay of bengal, bedrock, brahmaputra river, catastrophic breach, david montgomery, delta, downstream, eastern himalaya, Ganges River, isaac larsen, landslide, landslide erosion, mountain slopes, mountain terrain, plate tectonics, po tsangpo river, river, southeast tibet, southern asia, spy satellite photography, terrain uplift, tsangpo gorge, university of washington, vince stricherz, yarlung tsangpo river

Some of the steepest mountain slopes in the world got that way because of the interplay between terrain uplift associated with plate tectonics and powerful streams cutting into hillsides, leading to erosion in the form of large landslides, new research shows.

The work, presented online May 27 in Nature Geoscience, shows that once the angle of a slope exceeds 30 degrees – whether from uplift, a rushing stream carving away the bottom of the slope or a combination of the two – landslide erosion increases significantly until the hillside stabilizes.

“I think the formation of these landscapes could apply to any steep mountain terrain in the world,” said lead author Isaac Larsen, a University of Washington doctoral student in Earth and space sciences. (more…)

Engineered Microvessels Provide a 3-D Test Bed for Human Diseases

By Guest PostMay 31, 2012Science3 d test bed, abraham stroock, abundant protein, bioengineering, blood clots, bloodstream, cancer, chemical factor, collagen, cornell university, disease, endothelial cells, honeycomb, human, human blood vessels, human cancer, human cell, jose lopez, mechanical, mice and monkeys, michael craven, model, petri dish, samuel totorica, shear stress, tumor progression, university of washington, ying zheng

Mice and monkeys don’t develop diseases in the same way that humans do. Nevertheless, after medical researchers have studied human cells in a Petri dish, they have little choice but to move on to study mice and primates.

University of Washington bioengineers have developed the first structure to grow small human blood vessels, creating a 3-D test bed that offers a better way to study disease, test drugs and perhaps someday grow human tissues for transplant.

The findings are published online this week in the Proceedings of the National Academy of Sciences. (more…)

Powerful New Approach to Attack Flu Virus

By Guest PostMay 29, 2012Scienceadaptable virus, avian flu, biopharmaceutical industry, dna deep sequencing, flu epidemics, flu virus, H1N1, H5N1, Israel, kurt stepnitz, la jolla, michigan state university, mutations, nature biotechnology, new approach, pandemic influenza viruses, protein, rehovot, san diego, Science, scripps research institute, smallpox, subtypes, swine flu, therapeutic proteins, tim whitehead, university of washington, weizmann institute

EAST LANSING, Mich. — An international research team has manufactured a new protein that can combat deadly flu epidemics.

The paper, featured on the cover of the current issue of Nature Biotechnology, demonstrates ways to use manufactured genes as antivirals, which disable key functions of the flu virus, said Tim Whitehead, assistant professor of chemical engineering and materials science at Michigan State University.

“Our most potent design has proven effective on the vulnerable sites on many pandemic influenza viruses, including several H1N1 (Spanish flu, Swine flu) and H5N1 (Avian flu) subtypes,” said Whitehead, the paper’s co-lead author. “These new therapeutics are urgently needed, so we were especially pleased to see that it neutralizes H1N1 viruses with potency.” (more…)

It’s in the Genes: Research Pinpoints How Plants Know When to Flower

By Guest PostMay 27, 2012Nature, Scienceandrew millar, arabidopsis, barley, benjamin to, biofuels, biology, circadian clock, factors, fkf1 protein, flowering locus t, flowering plants, know, mathematical model, molecular changes, molecular events, photoreceptor, plant, plants, prediction, protein, robert smith, sandra hines, scientists, sequence, shoot apex, sunlight, takato imaizumi, time keeping mechanism, university of edinburgh, university of washington, uw lab, wheat, when to flower, young hun song

Scientists believe they’ve pinpointed the last crucial piece of the 80-year-old puzzle of how plants “know” when to flower.

Determining the proper time to flower, important if a plant is to reproduce successfully, involves a sequence of molecular events, a plant’s circadian clock and sunlight.

Understanding how flowering works in the simple plant used in this study – Arabidopsis – should lead to a better understanding of how the same genes work in more complex plants grown as crops such as rice, wheat and barley, according to Takato Imaizumi, a University of Washington assistant professor of biology and corresponding author of a paper in the May 25 issue of the journal Science. (more…)

How Public Should Public Records Be? Increased Availability Sparks Privacy Concerns

By Guest PostMay 16, 2012Media, Technologybatya friedman, changes in behavior, Facebook, james fogarty, mashup, online technology, pacific northwest, peter kelley, political campaign, privacy concern, public, public record, sean munson, university of washington, us citizen, us democracy, web, zillow and redfin

Online technology has vastly increased citizens’ access to public records such as political campaign contributions and real estate transactions. But that explosion of information availability also sparks privacy concerns and may dampen some people’s willingness to engage in public activities, according to recent research.

Six researchers, including two from the University of Washington, co-authored the paper “Attitudes Toward Online Availability of U.S. Public Records.” It was presented at the Proceedings of the 12th Annual International Digital Government Research Conference in College Park, Md. An expanded version of the article will appear in a forthcoming issue of Information Polity. (more…)

Portable Diagnostics Designed To Be Shaken, Not Stirred

By Guest PostMay 12, 2012Scienceashutosh shastry, asymmetrical surface, audio speaker, blood, energy, hannah hickey, karl bohringer, lotus effect, lotus leaf, medical researcher, menlo park, Nanotechnology, portable diagnostics, rough surface, saliva, smartphone, todd duncombe, university of washington, vibration, vibration frequency, water sample, yegan erdem

As medical researchers and engineers try to shrink diagnostics to fit in a person’s pocket, one question is how to easily move and mix small samples of liquid.

University of Washington researchers have built and patented a surface that, when shaken, moves drops along certain paths to conduct medical or environmental tests.

“This allows us to move drops as far as we want, and in any kind of layout that we want,” said Karl Böhringer, a UW professor of electrical engineering and bioengineering. The low-cost system, published in a recent issue of the journal Advanced Materials, would require very little energy and avoids possible contamination by diluting or electrifying the samples in order to move them. (more…)

Human Brain Evolution Tied to Partial Gene Copy That Blocks Original

By Guest PostMay 7, 2012Scienceafrican, brain development gene, chromosome, cortex, denisovans, embryology, evan eichler, evolutionary history, franck polleux, gene duplication, genus homo, homo sapiens, humans, hydatidiform mole, mammalian species, megan dennis, neanderthals, parent gene, peter sudmant, prehistoric human genome, primate, srgap2 gene family, university of washington, xander nuttle

A brain-development gene found exclusively in humans has an unusual evolutionary history and could contribute to what makes us distinctly human. Equally surprising, this is a partial gene created from an incomplete duplication of its “parent” gene in the prehistoric human genome.

Gene duplication is an important driving force in creating physical changes in living things during evolution, explained the researchers studying the SRGAP2 gene family. Drs. Megan Dennis and Xander Nuttle, in the Howard Hughes Medicine Institute research lab of Dr. Evan Eichler, University of Washington professor of genome sciences, co-authored the report on the findings. (more…)