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Portable Diagnostics Designed To Be Shaken, Not Stirred

By Guest PostMay 12, 2012Scienceashutosh shastry, asymmetrical surface, audio speaker, blood, energy, hannah hickey, karl bohringer, lotus effect, lotus leaf, medical researcher, menlo park, Nanotechnology, portable diagnostics, rough surface, saliva, smartphone, todd duncombe, university of washington, vibration, vibration frequency, water sample, yegan erdem

As medical researchers and engineers try to shrink diagnostics to fit in a person’s pocket, one question is how to easily move and mix small samples of liquid.

University of Washington researchers have built and patented a surface that, when shaken, moves drops along certain paths to conduct medical or environmental tests.

“This allows us to move drops as far as we want, and in any kind of layout that we want,” said Karl Böhringer, a UW professor of electrical engineering and bioengineering. The low-cost system, published in a recent issue of the journal Advanced Materials, would require very little energy and avoids possible contamination by diluting or electrifying the samples in order to move them. (more…)

Human Brain Evolution Tied to Partial Gene Copy That Blocks Original

By Guest PostMay 7, 2012Scienceafrican, brain development gene, chromosome, cortex, denisovans, embryology, evan eichler, evolutionary history, franck polleux, gene duplication, genus homo, homo sapiens, humans, hydatidiform mole, mammalian species, megan dennis, neanderthals, parent gene, peter sudmant, prehistoric human genome, primate, srgap2 gene family, university of washington, xander nuttle

A brain-development gene found exclusively in humans has an unusual evolutionary history and could contribute to what makes us distinctly human. Equally surprising, this is a partial gene created from an incomplete duplication of its “parent” gene in the prehistoric human genome.

Gene duplication is an important driving force in creating physical changes in living things during evolution, explained the researchers studying the SRGAP2 gene family. Drs. Megan Dennis and Xander Nuttle, in the Howard Hughes Medicine Institute research lab of Dr. Evan Eichler, University of Washington professor of genome sciences, co-authored the report on the findings. (more…)

Increasing Speed of Greenland Glaciers Gives New Insight for Rising Sea Level

By Guest PostMay 6, 2012EnvironmentAntarctica, benjamin smith, climate change, Germany, glaciologist, greenland glaciers, ian howat, ian joughin, ice, icebergs, Japan, meltwater, ocean, rising sea level, scenario, sea-level rise, terrasar x satellite, twila moon, university of washington

Changes in the speed that ice travels in more than 200 outlet glaciers indicates that Greenland’s contribution to rising sea level in the 21^st century might be significantly less than the upper limits some scientists thought possible, a new study shows.

“So far, on average we’re seeing about a 30 percent speedup in 10 years,” said Twila Moon, a University of Washington doctoral student in Earth and space sciences and lead author of a paper documenting the observations published May 4 in Science. (more…)

Handful of Heavyweight Trees Per Acre Are Forest Champs

By Guest PostMay 5, 2012Natureandrew larson, biomass, carbon dioxide, dynamic process, fir, incense cedars, james freund, james lutz, little ice age, mark swanson, photosynthesis, plant tissue, sandra hines, sugar, temperate forest, trees, trunk, university of montana, university of washington, washington state university, yosemite national park

Big trees three or more feet in diameter accounted for nearly half the biomass measured at a Yosemite National Park site, yet represented only 1 percent of the trees growing there.

This means just a few towering white fir, sugar pine and incense cedars per acre at the Yosemite site are disproportionately responsible for photosynthesis, converting carbon dioxide into plant tissue and sequestering that carbon in the forest, sometimes for centuries, according to James Lutz, a University of Washington research scientist in environmental and forest sciences. He’s lead author of a paper on the largest quantitative study yet of the importance of big trees in temperate forests being published online May 2 on PLoS ONE. (more…)

Plastic Pollution

By Guest PostMay 2, 2012Environmentalgae, bacteria, dylan meyer, environmental group, factor, giora proskurowski, historical weather data, kara lavendar law, liver function, mathematical model, model, north atlantic expedition, ocean, pacific garbage patch, plastic marine debris, plastic particles, plastic pollution, pollutant, recipe, skye moret ferguson, teresa messmore, tobias kukulka, university of delaware, university of washington, wind

Wind pushes plastics deeper into oceans, driving trash estimates up

Decades of research into how much plastic litters the sea may have only skimmed the surface. A new study reveals that wind drives confetti-sized pieces of plastic debris deeper underwater than previously believed, more than doubling earlier estimates of the pollutant’s presence in oceans.

“In windy conditions the traditional approach to measuring plastic marine debris captures only a small fraction of plastic pieces,” said Tobias Kukulka, assistant professor of physical ocean science and engineering in the University of Delaware’s College of Earth, Ocean, and Environment. “Our study helps to better understand how much plastic there is and where, as well as the complexity of the ocean dynamics at work.” (more…)

Cells in Blood Vessel Found To Cling More Tightly in Regions of Rapid Flow

By Guest PostApril 27, 2012Health, Sciencebenjamin shuman, biochemical change, blockage, cardiac surgeon, cardiovascular disease, cell, cholesterol, clogging, heart, joon jung, living organ, lucas ting, mechanical engineering, nathan sniadecki, sangyoon han, shirin feghhi, surgeon, tugging force, university of washington, vascular leakage

Clogging of pipes leading to the heart is the planet’s number one killer. Surgeons can act as medical plumbers to repair some blockages, but we don’t fully understand how this living organ deteriorates or repairs itself over time.

Researchers at the University of Washington have studied vessel walls and found the cells pull more tightly together, reducing vascular leakage, in areas of fast-flowing blood. The finding could influence how doctors design drugs to treat high cholesterol, or how cardiac surgeons plan their procedures. (more…)

Some Mammals Used Highly Complex Teeth to Compete With Dinosaurs

By Guest PostMarch 19, 2012Nature, Science3 d images, alistair evans, angiosperms, australia, back teeth, bumps, computed tomography, ct, cusps, dinosaur extinction, dinosaurs, event, extinction, finland, food, fossil, gregory p wilson, ian corfe, insect pollinators, jukka jernvall, mammal, mesozoic era, mikael fortelius, monash university, mountain range, multituberculates, Nature, paleontologist, peter smits, rodent, scanning, tooth surface, topography, tubercles, university of helsinki, university of washington, vince stricherz

Conventional wisdom holds that during the Mesozoic Era, mammals were small creatures that held on at life’s edges. But at least one mammal group, rodent-like creatures called multituberculates, actually flourished during the last 20 million years of the dinosaurs’ reign and survived their extinction 66 million years ago.

New research led by a University of Washington paleontologist suggests that the multituberculates did so well in part because they developed numerous tubercles (bumps, or cusps) on their back teeth that allowed them to feed largely on angiosperms, flowering plants that were just becoming commonplace. (more…)

Loss of Appetite Deciphered in Brain Cell Circuit

By Guest PostMarch 14, 2012Scienceanorexia nervosa, body, brain, brain development, cancer chemotherapy, excitatory signal, experimental result, food aversions, function, gaba, glutamate, hypothalamus, loss of appetite, meal, mice, michael s clark, michael schwartz, nausea, nerve cells, nucleus tractus solitarus, parabrachial nucleus, point of emaciation, qi wu, ralph brinster, receptor, richard d palmiter, starvation, substance, transgenic mice, university of pennsylvania, university of washington

The meal is pushed way, untouched. Loss of appetite can be a fleeting queasiness or continue to the point of emaciation. While it’s felt in the gut, more is going on inside the head.

New findings are emerging about brain and body messaging pathways that lead to loss of appetite, and the systems in place to avoid starvation. (more…)

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