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Scientists Defuse the Vietnam Time Bomb

By Guest PostNovember 11, 2011Health, Sciencebacterial pathogen, bacterium, burkholderia, burkholderia pseudomallei, cancer, david rice, deadly tropical disease, diseases, drugs, endemic areas, esrf, european synchrotron radiation facility, france, grenoble, hiv and tuberculosis, kevin van cauter, key mechanism, melioidosis, northern australia, pmi2 funding, protein synthesis, rick titball, south east asia, structure of a protein, stuart wilson, therapies to prevent the proliferation of cancer cells, university of exeter, university of sheffield, us military personnel, vietnam time bomb, xrays at diamond light source

A key mechanism by which a bacterial pathogen causes the deadly tropical disease melioidosis has been discovered by an international team, including a University of Exeter scientist.

The findings are published in the journal Science and show how a toxin produced by the bacterium Burkholderia pseudomallei kills cells by preventing protein synthesis.

The study, led by the University of Sheffield, paves the way for the development of novel therapies to combat the bacterium which infects millions of people across South East Asia and Northern Australia.

Using intense X-rays at Diamond Light Source, the UK’s national synchrotron facility, and at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, the research team solved the structure of a protein from Burkholderia, the function of which was initially unknown. (more…)

‘Combining Therapies Appears Safe, May Benefit Patients with Advanced Liver Cancer’

By Guest PostJuly 9, 2011Healthadvanced primary liver cancer, bayer healthcare, cancer, chronic hepatitis c infection, cirrhosis, diarrhea, drugs, epidemics of obesity and diabetes, fatigue, hcc, hepatocellular carcinoma, hepatologists, inflammation, james caridi, liver cancer, metabolic syndrome, nonalcoholic fatty liver disease, onyx pharmaceuticals, paul martin, roniel cabrera, side effects, skin reactions, sorafenib, transarterial chemoembolization, tumor feeding blood vessels, tumors, type of liver cancer, unexpected toxic effects, united states, university of florida, university of miami, viable treatment options, world health organization

GAINESVILLE, Fla. — Few treatments exist for patients with advanced primary liver cancer, but University of Florida researchers have found a new way to broaden the range of options and potentially improve health outcomes by combining two treatments.

In the first study of its kind, the researchers combined sorafenib, the only Food and Drug Administration-approved pill for treating advanced liver cancer, with another routinely used therapy known as transarterial chemoembolization, which works by cutting off the blood supply to tumors. No unexpected toxic effects were seen, and the combo appears to have the potential to improve survival for certain groups of patients. (more…)

Fighting Words: Violent Political Rhetoric Fuels Violent Attitudes

By Guest PostJanuary 24, 2011Politicsamericans, arizona, combat, daily life, democrats, disease, drugs, fight, gabrielle giffords, nathan kalmoe, negative consequences, non violent text, party affiliation, political leaders, political rhetoric, political violence, poverty, republicans, social problems, terrorism, us house candidates, violent attitudes, violent language, war, words

ANN ARBOR, Mich.— Political leaders regularly promise to “fight” for noble causes and “combat” pressing problems. They declare “war” on social problems, such as poverty, disease, drugs and terrorism.

This violent political rhetoric—whether politicians intend to or not—can enflame violent attitudes in many Americans, especially those predisposed to behave aggressively in daily life, according to new University of Michigan research involving three studies. (more…)

Young People Say Sex, Paychecks Come in Second to Self-Esteem

By Guest PostJanuary 9, 20111 commentCulturealcohol, american society, brad bushman, college students, drugs, favorite foods, obsession, ohio state, ohio state university, psychology, scott moeller, self-esteem, sex, young people

COLUMBUS, Ohio – Young people may crave boosts to their self-esteem a little too much, new research suggests.

Researchers found that college students valued boosts to their self-esteem more than any other pleasant activity they were asked about, including sex, favorite foods, drinking alcohol, seeing a best friend or receiving a paycheck. (more…)

X-Ray Diffraction May Play Key Role in Stopping ‘Kissing Bug,’ Fungus

By Guest PostOctober 22, 2010Health, Scienceaspergillus fumigates, blood-sucking insect, chagas parasite, crime scenes, cure, dale karr, drugs, enzyme, fungus, john tanner, kissing bug, organisms, pablo sobrado, parasite, pathogens, pulmonary diseases, south america, sugar molecule, virginia tech, x ray diffraction

John Tanner, who also teaches chemistry in the College of Arts and Science, is studying Aspergillus fumigatus. Image credit: University of Missouri

COLUMBIA, Mo. – If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.

Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two “crime scenes”: in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the “kissing bug” for the red welts left on the victims’ faces after being bitten in his or her sleep.

“My job is to figure out what the enzyme looks like using X-ray diffraction,” Tanner said. “This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens.” (more…)

The Price of Popularity: Drug and Alcohol Consumption

By Guest PostSeptember 29, 20101 commentCulturealcohol, canada, consumption, drugs, emotional troubles, frank vitaro, frédéric brière, hard drugs, jean-sébastien fallu, marijuana, popularity, popularity and consumption, stéphane cantin, teenagers, university of oslo

The consumption of drugs and alcohol by teenagers is not just about rebellion or emotional troubles. It’s about being one of the cool kids, according to a study by led by researchers at the Université de Montréal. “Our study highlights a correlation between popularity and consumption,” says Jean-Sébastien Fallu, lead researcher and professor at the Université de Montréal’s School of Psychoeducation. “The teenagers we studied were well-accepted, very sensitive to social codes, and understood the compromises that it takes to be popular.”

(more…)

Afghanistan’s Natural Wealth Evaluated at $1 Trillion

By PravdaJune 18, 2010Economyafghan economy, afghanistan, american geologists, blackberrys, China, cobalt, copper, drugs, gold, hamid karzai, iron, kabul, laptops, lithium, Pakistan, soviet scientists, taliban, united states

In Afghanistan, American geologists have discovered deposits of iron, copper, lithium, cobalt, and gold worth $1 trillion.

Experts believe that these reserves may not only stop the poverty in one of the poorest countries in the world, but turn Afghanistan in a flourishing country and one of the largest centers of natural resources excavation.

(more…)

‘Cocainizing the Astronauts’

By ShamsJanuary 27, 20105 commentsCulture, Scienceastronauts, baidu, cannabis, China, chinese, coca, cocaine, cosmonauts, discovery, drugs, extra vehicular activity, godfather, Google, great britain, heroin, hp, infinite zone, marijuana, maxim suraev, Microsoft, NASA, oleg kotov, opium, opium war, opiumize, poppy, queen victoria, shuttle, space walk, stephen hawking, third opium war

Heroin, Cocaine, Marijuana. You know them all. They are just brothers and sisters, and belong to one big and powerful family (commonly known as drugs, or druggs etc.).

May be you would like to ask, “OK, it’s a family, then who is the father”.

(more…)

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