During a stroke or organ transplant, patients can suffer an injury due to lack of blood supply to vital organs. The injury — known as ischemia reperfusion — can cause damage to tissues. But a new Yale-led study has identified a previously unknown mechanism leading to the injury, and a potential target for drug treatment. (more…)
Doctors have no approved medicine to help treat marijuana dependence and abuse, but in small new clinical trial topiramate reduced the amount of cannabis heavy smokers used when they lit up. The results also show, however, that many volunteers couldn’t tolerate the drug’s side effects. (more…)
ANN ARBOR—A banana a day may not keep the doctor away, but a substance originally found in bananas and carefully edited by scientists could someday fight off a wide range of viruses, new research suggests. (more…)
A new drug, called pritelivir, may offer a new treatment option for patients with genital herpes, a new industry-sponsored – study led by University of Washington researchers has found.
The study appears in this week’s issue of the New England Journal of Medicine. The lead author is Anna Wald, M.D., professor of medicine, epidemiology, and laboratory medicine, and medical director at the Virology Research Clinic at the University of Washington. Other UW coauthors include Dr. Amalia Magaret, Dr. Christine Johnston, Dr. Lawrence Corey, Dr. Meei-Li Huang and Stacy Selke. (more…)
There is no approved medicine to treat polyomaviruses, which afflict people with weakened immune systems, but scientists have found that a chemical compound called Retro-2 is able to reduce significantly the infectivity and spread of the viruses in lab cell cultures. Now they are working to improve it.
PROVIDENCE, R.I. [Brown University] — A team of scientists reports that a small-molecule compound showed significant success in controlling the infectivity and spread of three polyomaviruses in human cell cultures. To date there has been no medicine approved to treat such viruses, which prey on transplant recipients, people with HIV, and others whose immune systems have been weakened. (more…)
In many ways, the spread of HIV has been fueled by substance abuse. Shared needles and drug users’ high-risk sexual behaviors are just some of the ways that narcotics such as cocaine have played a key role in the AIDS epidemic in much of the world.
There is, however, relatively little research into how drugs can impact the body’s defenses against the virus. But a new UCLA study published in the October issue of the Journal of Leukocyte Biology examines how cocaine affects a unique population of immune cells called quiescent CD4 T cells, which are resistant to the virus that causes AIDS. (more…)
The gut bacteria of honey bees have acquired several genes that confer resistance to tetracycline, a direct result of more than five decades of use of antibiotics by American beekeepers and a potential health hazard for bee colonies, a new study by Yale University researchers show.
The genetic analysis of the gut bacteria, which are believed to help in bees’ digestion and ability to ward off parasites, suggests changing antibiotic use by beekeepers might be one factor in the mysterious colony collapse disorder afflicting bee populations. (more…)
Doctors can improve treatment programs using this knowledge
COLUMBIA, Mo. – The human immunodeficiency virus (HIV) can contain dozens of different mutations, called polymorphisms. In a recent study an international team of researchers, including University of Missouri scientists, found that one of those mutations, called 172K, made certain forms of the virus more susceptible to treatment. Soon, doctors will be able to use this knowledge to improve the drug regimen they prescribe to HIV-infected individuals.
“The 172K polymorphism makes certain forms of HIV less resistant to drugs,” said Stefan Sarafianos, corresponding author of the study and a researcher at MU’s Bond Life Sciences Center. “172K doesn’t affect the virus’ normal activities. In some varieties of HIV that have developed resistance to drugs, when the 172K mutation is present, resistance to two classes of anti-HIV drugs is suppressed. We estimate up to 3 percent of HIV strains carry the 172K polymorphism.” (more…)
