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HIV spreads like internet malware and should be treated earlier

By Guest PostApril 13, 2015Healthaids, binnenschifffahrt, cd4 t cells, ed yong, elements of failure, folgen von duerre, infection process, international conflict, liz neeley, power law distribution, power of narrative, preventing world war, science writing, small war

A new model for HIV progression finds that it spreads in a similar way to some computer worms and predicts that early treatment is key to staving off AIDS.

HIV specialists and network security experts at UCL noticed that the spread of HIV through the body using two methods – via the bloodstream and directly between cells – was similar to how some computer worms spread through both the internet and local networks respectively to infect as many computers as possible. They worked together to create a model for this ‘hybrid spreading’, which accurately predicted patients’ progression from HIV to AIDS in a major clinical trial. (more…)

A new device deciphers the language of cells

By Guest PostJune 7, 2014Healthankur chakravarthy, attract, biotechnologist, bottleneck, cd4 t cells, China, decipher, era, fitcode, hpv cancers, jeans, new device, oropharyngeal cancers, peter schulam, proportionate booty, prostate cancer, rian buckley, stephanie chacharon, Technology, tim fenton, tonsil cancers, tumour development, united states, yale

A biomedical engineer listens in on what proteins are saying.

As inventions go, Yale biomedical engineer Rong Fan’s entry into the innovation sweepstakes is not much to look at. Fan’s device, impressively named a single-cell, 45-plex protein secretion measurement platform, seems to be little more than a sandwich of two sheets of clear silicon rubber the thickness of window glass, each sheet a bit smaller than a credit card and bearing a smaller, darker rectangle divided into 14 vertical sections. It has no flashing lights, no intriguing noises, no moving parts, no signs of Applesque high design. Indeed, the object, displayed in Fan’s bustling laboratory on the first floor of the Daniel L. Malone Engineering Center, doesn’t appear to be doing anything at all. (more…)

Nature Medicine

By Guest PostJanuary 14, 2014Health, Sciencecd4 t cells, fabian cardozo, hiv, hiv reservoir, hiv treatments, hiv virus replication, immune response, infected cell, mathias lichterfeld, memory tcells, metabolic pathways, mgh, nature medicine, quiescent infections, role, ryan zurakowski, stem cell, stop the infection, t cell type, t cells, therapy, thymus gland, tscm, type of lymphocyte, university of delaware, white blood cell

Engineering professor co-authors Nature Medicine paper on HIV

Ryan Zurakowski, assistant professor of electrical and computer engineering at the University of Delaware, is co-author of a paper appearing in Nature Medicine on Jan. 12 highlighting the role of T-cells in HIV.

The paper, titled “HIV-1 Persistence in CD4+ T-Cells with Stem Cell-Like Properties,” provides evidence that a particular T-cell type may help researchers better understand why HIV can persist despite treatment. (more…)

Cocaine use can make otherwise resistant immune cells susceptible to HIV

By Guest PostOctober 5, 2013Healthaids epidemic, cd4 t cells, chronic user, cocaine, dhaval dixit, dimitrios vatakis, drug, gayle baldwin, high risk, immune cell, in vitro study, infected by virus, infected cells, james jung, jerome zack, life cycle, narcotics, quiescent, robert rovner, sexual behavior, sohn kim, substance abuse, susceptible to hiv

In many ways, the spread of HIV has been fueled by substance abuse. Shared needles and drug users’ high-risk sexual behaviors are just some of the ways that narcotics such as cocaine have played a key role in the AIDS epidemic in much of the world.

There is, however, relatively little research into how drugs can impact the body’s defenses against the virus. But a new UCLA study published in the October issue of the Journal of Leukocyte Biology examines how cocaine affects a unique population of immune cells called quiescent CD4 T cells, which are resistant to the virus that causes AIDS. (more…)

Tag Archives: cd4 t cells

HIV spreads like internet malware and should be treated earlier

A new device deciphers the language of cells

Nature Medicine

Cocaine use can make otherwise resistant immune cells susceptible to HIV