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Southern exposure: 21% of U.S. elderly take high-risk medicines

By Guest PostMay 6, 2013Generalalbany, amal trivedi, brown university, danya qato, demographic analysis, high risk medication, hospital referral regions, hrrs, mason city, medicare advantage plans, new england, pharmacist, poor areas, public health researchers, seniors, seniors in alexandria, south atlantic, south carolina, southeast united states, texas

A study of more than 6 million seniors in Medicare Advantage plans in 2009 found that 21 percent received a prescription for at least one potentially harmful “high-risk medication.” Nearly 5 percent received at least two. Questionable prescriptions are more common in the South and among people who live in poor areas.

PROVIDENCE, R.I. [Brown University] — More than one in five seniors with Medicare Advantage plans received a prescription for a potentially harmful “high-risk medication” in 2009, according to an analysis by Brown University public health researchers. The questionable prescriptions were significantly more common in the Southeast United States, as well as among women and people living in relatively poor areas. (more…)

Subconscious mental categories help brain sort through everyday experiences

By Guest PostMay 2, 2013Health, Scienceanna schapiro, brain, brown university, chopping vegetables, computational model, dynamic, experiences, functional, magnetic resonance imaging, matthew botvinick, michael frank, natalia cordova, nature neuroscience, neural populations, nicholas turk browne, princeton university, similarity structure, subconscious mental, temporal relationship, timothy rogers

Your brain knows it’s time to cook when the stove is on, and the food and pots are out. When you rush away to calm a crying child, though, cooking is over and it’s time to be a parent. Your brain processes and responds to these occurrences as distinct, unrelated events.

But it remains unclear exactly how the brain breaks such experiences into “events,” or the related groups that help us mentally organize the day’s many situations. A dominant concept of event-perception known as prediction error says that our brain draws a line between the end of one event and the start of another when things take an unexpected turn (such as a suddenly distraught child). (more…)

A new approach to spinal muscular atrophy?

By Guest PostMay 1, 2013Healthals drug, amyotrophic lateral sclerosis, anne hart, boston, brown university, caenorhabditis elegans worm, children hospital, doctors for riluzole, maria dimitriadi, model of sma, neuromuscular disease, new therapy, normal cells, protein, riluzole, sk2 channels, sk2 potassium channels, sma treatment, smn, spinal muscular atrophy, survival motor neuron, united states, worm neurons

Spinal muscular atrophy is a debilitating neuromuscular disease that in its most severe form is the leading genetic cause of infant death. By experimenting with an ALS drug in two very different animal models, researchers at Brown University and Boston Children’s Hospital have identified a new potential mechanism for developing an SMA treatment.

PROVIDENCE, R.I. [Brown University] — There is no specific drug to treat spinal muscular atrophy (SMA), a family of motor neuron diseases that in its most severe form is the leading genetic cause of infant death in the United States and affects one in 6,000 people overall. But a new multispecies study involving a drug that treats amyotrophic lateral sclerosis (ALS) has pinpointed a mechanism of SMA that drug developers might be able to exploit for a new therapy. (more…)

Carbon’s role in atmosphere formation

By Guest PostApril 27, 2013Sciencealberto saal, atmosphere, atmosphere formation, atmospheric evolution, brown, brown university, carbon, carbon monoxide, carnegie institution, diane wetzel, erik hauri, evolution of planet, greenhouse conditions, high greenhouse potential, iron carbonyl, liquid water, magma, malcolm rutherford, mars, mars history, methane, methane gas, northwestern university, oxygen fugacity, role, steven jacobsen, subsurface carbon, volcanism, Washington

A new study in Proceedings of the National Academy of Sciences suggests that the way carbon moves from within a planet to the surface plays a big role in the evolution of a planet’s atmosphere. If Mars released much of its carbon as methane, for example, it might have been warm enough to support liquid water.

PROVIDENCE, R.I. [Brown University] — A new study of how carbon is trapped and released by iron-rich volcanic magma offers clues about the early atmospheric evolution on Mars and other terrestrial bodies. (more…)

Invasive crabs help Cape Cod marshes

By Guest PostApril 15, 2013Naturebrown university, cape cod, carcinus maenas, catherine matassa, ecological function, ecologists, erosion, grass eating crabs, invasion, invasive green crab, long vilified, mark bertness, marsh, non consumptive effects, non native species, predatory green crabs, sesarma reticulatum crabs, shores, tyler coverdale

Ecologists are wary of non-native species, but along the shores of Cape Cod where grass-eating crabs have been running amok and destroying the marsh, an invasion of a predatory green crabs has helped turn back the tide in favor of the grass. The counter-intuitive conclusions appear in a new paper in the journal Ecology.

PROVIDENCE, R.I. [Brown University] — Long vilified, invasive species can sometimes become an ecosystem asset. New Brown University research published online in the journal Ecology reports exactly such a situation in the distressed salt marshes of Cape Cod. There, the invasive green crab Carcinus maenas is helping to restore the marsh by driving away the Sesarma reticulatum crabs that have been depleting the marsh grasses. (more…)

Misregulated genes may have big autism role

By Guest PostApril 1, 2013Healthautism, autism cerebral cortex, bank, biochemical exchanges, brain tissue, brains of children, brown university, christianson syndrome, daniel geschwind, endosomes of cells, epilepsy, eric morrow, genetic pathway, human behavior, irinia voineagu, karoly mirnics, key molecular player, krassimira garbett, los angeles, messenger rna, misregulated genes, mutations, nhe6, nhe9, proteins, raw data, statistical analysis, university of california, vanderbilt university

A genetic pathway involving proteins in the endosomes of cells appears to be misregulated in the brains of children with autism, according to a newly published statistical analysis in the journal Molecular Psychiatry. Previously the genes were shown to cause rare forms of the disease but the new study suggests they have a wider role.

PROVIDENCE, R.I. [Brown University] — A new study finds that two genes individually associated with rare autism-related disorders are also jointly linked to more general forms of autism. The finding suggests a new genetic pathway to investigate in general autism research. (more…)

Lunar impacts created seas of molten rock

By Guest PostMarch 25, 2013Scienceanalysis of data, apollo moon rocks, apollo program, brown university, crust, differentiation, differentiation processes, fluid rock, geological sciences, james w head, laser altimeter, liquid rock, lola, luna missions, lunar crust, lunar magma ocean, lunar orbiter, magma ocean paradigm, mantle, maunder crater, melt sea, model, molten rock, moon, NASA, orientale basin, orientale melt, planetary geologist, pristine rocks, remote sensing data, rock forming processes, rock layers, russia, william vaughan

A new analysis of data from NASA’s Lunar Orbiter Laser Altimeter (LOLA) shows that molten rock may have been present on the Moon more recently and for longer periods than previously thought. Differentiation — a settling out of rock layers as liquid rock cools — would require thousands of years and a fluid rock sea at least six miles deep.

PROVIDENCE, R.I. [Brown University] — Early in the Moon’s history an ocean of molten rock covered its entire surface. As that lunar magma ocean cooled over millions of years, it differentiated to form the Moon’s crust and mantle. But according to a new analysis by planetary scientists from Brown University, this wasn’t the last time the Moon’s surface was melted on a massive scale. (more…)

Under California: An ancient tectonic plate

By Guest PostMarch 19, 2013Scienceancient tectonic plate, baja peninsula, brian savage, brown university, california, california coast, central california, christina rau, columbia university, donald forsyth, farallon oceanic plate, geologist, high velocity anomaly, isabella anomaly, james gaherty, lithospheric plate, Mexico, nina carriero, north american plate, pacific, rhode island, san andreas fault, seismic tomography data, seismic tomography signature, sierra nevada mountains, under california, university, university of oregon, west coast, yun wang

The Isabella anomaly — indications of a large mass of cool, dehydrated material about 100 kilometers beneath central California — is in fact a surviving slab of the Farallon oceanic plate. Most of the Farallon plate was driven deep into the Earth’s mantle as the Pacific and North American plates began converging about 100 million years ago, eventually coming together to form the San Andreas fault.

PROVIDENCE, R.I. [Brown University] — Large chunks of an ancient tectonic plate that slid under North America millions of years ago are still present under parts of central California and Mexico, according to new research led by Brown University geophysicists. (more…)

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