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Building Molecular ‘Cages’ to Fight Disease

By Guest PostJune 9, 2012Scienceartificial vaccines, bioinformatics, biomedical engineering, building blocks, circulation, david baker, drug, drug delivery, duilio cascio, human like proteins, lego blocks, medicine, michael sawaya, molecular biology, molecular cages, molecular structure, nanoscale materials, neil king, puzzle pieces, specialized proteins, tangles of ribbon, three-dimensional, tiny structures, todd yeates, traditional vaccine, tumor cells, ucla, university of washington, virus derived proteins, yen ting lai

UCLA-created nanoscale protein containers could aid drug, vaccine delivery

UCLA biochemists have designed specialized proteins that assemble themselves to form tiny molecular cages hundreds of times smaller than a single cell. The creation of these miniature structures may be the first step toward developing new methods of drug delivery or even designing artificial vaccines.

“This is the first decisive demonstration of an approach that can be used to combine protein molecules together to create a whole array of nanoscale materials,” said Todd Yeates, a UCLA professor of chemistry and biochemistry and a member of the UCLA–DOE Institute of Genomics and Proteomics and the California NanoSystems Institute at UCLA. (more…)

A Prime Seat to a Once-in-a-Lifetime Spectacle

By Guest PostJune 8, 2012Scienceadam block, alan strauss, astrophotographer, black void, digital slr camera, earth, east coast, England, exoplanets, expedition, filaments, Hubble Space Telescope, hydrogen alpha filter, jeremiah horrocks, liverpool, martin hamar, mount lemmon skycenter, much hoole, planet, planet venus, schulman telescope, southern arizona, sun, telescope, transit of venus, ua, venus, venus transit, village

Hosted by world-renowned astrophotographer Adam Block at the UA’s Mount Lemmon SkyCenter, a group of sky and astronomy enthusiasts watched Venus cross the sun from the highest vantage point in Southern Arizona.

On Nov. 24, 1639, in the tiny village of Much Hoole not far from Liverpool, England, a poor farmer’s son and self-taught astronomer affixed a sheet of paper in front of a makeshift telescope pointed at the sun and waited.

Thirty-five minutes before sunset, a dark, round spot appeared right next to the bright disc that was the sun’s face projected on the paper, and made Jeremiah Horrocks, only 20 years old at the time, the first known human to predict, observe and record a transit – the passage of a planet across the sun as seen from Earth.

Almost 373 years later, a group of sky enthusiasts is gathered beneath the dome of one of the University of Arizona’s observatories on Mount Lemmon just north of Tucson, Ariz. (more…)

A New Tool to Attack the Mysteries of High-Temperature Superconductivity

By Guest PostJune 8, 2012Scienceabsolute zero, advanced light source, alessandra lanzara, als, band structure, bardeen cooper schrieffer, bcs theory, beams of xrays, Berkeley, berkeley lab, bi2212, christopher smallwood, conventional superconductors, cooper pairs, dung hai lee, electric current, electric grids, electrons, energy savings, femtosecond scale pulses, high tc, high temperature, joseph orenstein, msd, quasiparticles, relaxation process, resistance, superconductivity, synchrotron light sources, through frequency, transmission, ultrafast laser arpes, university of california

Berkeley Lab researchers use an ultrafast laser to better understand high-temperature superconductors

Superconductivity, in which electric current flows without resistance, promises huge energy savings – from low-voltage electric grids with no transmission losses, superefficient motors and generators, and myriad other schemes. But such everyday applications still lie in the future, because conventional superconductivity in metals can’t do the job.

Although they play important roles in science, industry, and medicine, conventional superconductors must be maintained at temperatures a few degrees above absolute zero, which is tricky and expensive. Wider uses will depend on higher-temperature superconductors that can function well above absolute zero. Yet known high-temperature (high-Tc) superconductors are complex materials whose electronic structures, despite decades of work, are still far from clear. (more…)

CU-Boulder Physicists Use Ultrafast Lasers to Create First Tabletop X-Ray Device

By Guest PostJune 7, 2012Sciencebeams of xrays, laser like beams, tabletop device, ultrafast lasers, xray laser, xray photon

An international research team led by the University of Colorado Boulder has generated the first laser-like beams of X-rays from a tabletop device, paving the way for major advances in many fields including medicine, biology and nanotechnology development. (more…)

How Ion Bombardment Reshapes Metal Surfaces

By Guest PostJune 6, 2012Scienceadatom island eruption, crowding of atoms, fcc metals, ion beam bombardment, ion bombardment, metal surface, nanomanufacturing technique, nanotechnology products

Ion bombardment of metal surfaces is an important, but poorly understood, nanomanufacturing technique. New research using sophisticated supercomputer simulations has shown what goes on in trillionths of a second. The advance could lead to better ways to predict the phenomenon and more uses of the technique to make new nanoscale products.

PROVIDENCE, R.I. [Brown University] — To modify a metal surface at the scale of atoms and molecules — for instance to refine the wiring in computer chips or the reflective silver in optical components — manufacturers shower it with ions. While the process may seem high-tech and precise, the technique has been limited by the lack of understanding of the underlying physics. In a new study, Brown University engineers modeled noble gas ion bombardments with unprecedented richness, providing long-sought insights into how it works. (more…)

We Need to Talk: Study Shows How Developing Cells Communicate to Activate Notch Signaling

By Guest PostJune 6, 2012Scienceimmature cells, multicellular organisms, notch cells, notch signaling, notch system, signaling system

During early development in humans and other multicellular organisms, immature cells need to talk to each other to make critical decisions about what types of cells they should become, as well as when and where to become those cell types. (more…)

Ceramics Tell the Story of an Ancient Southwest Migration

By Guest PostJune 5, 2012Scienceceramic objects, ceramics, ceramics from kinishba, excavation techniques, kinishba pottery, pottery collection

Another look at a nearly 80-year-old pottery collection at the Arizona State Museum is yielding new information about migrants who abandoned the Four Corners region.

Approximately eight centuries ago, people living along the Colorado Plateau in what is now the Four Corners area faced a crisis. Environmental changes that devastated their agricultural practices and likely aggravated social unrest forced significant numbers of these people to move away. (more…)

Homing in on Higgs: Michigan Researchers Predict Summer Discovery

By Guest PostJune 4, 2012Scienceaaron armbruster, algorithms, atlas, atoms, bing zhou, CERN, Chicago, electromagnetic radiation, electrons, fermilab, forces, function, geneva, gordon kane, higgs, higgs boson, higgs field particles, homer neal, jianming qian, junjie zhu, Large Hadron Collider, laws, laws of nature, lhc, missing piece, Nature, neutrons, newton, particle physics, physics theory, protons, quarks, rudolf thun, standard model, stephen hawking, summer, switzerland, tevatron particle accelerator, university of michigan, vacuum like state

ANN ARBOR, Mich.— Whether the Higgs boson exists could be settled by the end of summer, say University of Michigan physicists involved in the search for the missing piece of particle physics’ Standard Model.

“We’re zooming in,” said Jianming Qian, physics professor in the College of Literature, Science & the Arts. “We are increasing the data set and improving our search algorithms. With certain luck, we may be able to discover it this summer, but it depends on nature.”

Qian is one of the 28 U-M researchers involved in experiments at CERN’s Large Hadron Collider (LHC) in Switzerland. He’ll spend most of his time through August in Geneva, where more than 1,000 scientists from around the world have been looking for Higgs since the collider turned on about four years ago. (more…)

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