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Breast Tenderness Following Combo Hormone Therapy Linked To Increased Breast Density

By Guest PostOctober 23, 2011Health, Sciencebaseline breast density in mammograms, breast cell proliferation, breast tenderness, breast tissue growth, breasts, carolyn crandall, changes in breast density, combination estrogen and progestin therapy, combination therapy, dense breasts, development of breast tenderness, estrogen therapy, hormone therapy, hysterectomy, jonsson cancer center, mammographic density, placebo, post menopausal women, risk of breast cancer, risk of uterine cancer, whi

*Study examines biology underlying link between tenderness, cancer risk*

Post-menopausal women who experience breast tenderness after starting combination hormone therapy have a higher risk of breast cancer than women who don’t, a study by researchers with UCLA’s Jonsson Comprehensive Cancer Center has shown. One reason for this, they now say, may be that these women’s breasts are becoming more dense.

Such new-onset tenderness was found to be more pronounced after the start of combination estrogen-and-progestin therapy than with estrogen therapy alone. The link between new-onset tenderness and changes in breast density also was more pronounced in women on combination therapy, said the study’s first author, Dr. Carolyn Crandall, a UCLA professor of general internal medicine and a scientist with the Jonsson Cancer Center. (more…)

Researchers Do Precise Gene Therapy Without A Needle

By Guest PostOctober 21, 2011Health, Scienceandrew morss, anti cancer gene, billionth of a meter, brian henslee, cell, early cancer detection and treatment, electrical pulses, fluorescent molecules, gene therapy, genetic pathways, gold coated dna strands, human cells, l james lee, leukemia cells, lung cancer, nanochannel electroporation, nanometer, nanometer sized channels, needle, nep, ohio state university, polymer stamps, polymeric device, pouyan boukany, reservoir of therapeutic agent, scale channel, therapeutic biomolecules, tumors, wei ching liao

COLUMBUS, Ohio – For the first time, researchers have found a way to inject a precise dose of a gene therapy agent directly into a single living cell without a needle.

The technique uses electricity to “shoot” bits of therapeutic biomolecules through a tiny channel and into a cell in a fraction of a second.

L. James Lee and his colleagues at Ohio State University describe the technique in the online edition of the journal Nature Nanotechnology, where they report successfully inserting specific doses of an anti-cancer gene into individual leukemia cells to kill them. (more…)

New Research Links Common RNA Modification to Obesity

By Guest PostOctober 19, 2011Healthanti obesity therapies, metabolic disease, methylation, obesity, rna epigenetics, rna modification

An international research team has discovered that a pervasive human RNA modification provides the physiological underpinning of the genetic regulatory process that contributes to obesity and type II diabetes. (more…)

New Method helps Researchers Zero in on Drugs that can kill Brain Cancer Stem Cells

By Guest PostOctober 17, 2011Health, Sciencebiobehavioral sciences, brain cancer, brain tumors, dr. harley kornblum, glioblastoma, identify chemical compounds, jonsson cancer center, kill the stem cells, malignancies, molecular cancer therapeutics, new cancer drugs, new screening approach, seven chemical libraries, treatment-resistant, tumor cells, typical screening, ucla's jonsson comprehensive cancer center, university of california

Researchers with UCLA’s Jonsson Comprehensive Cancer Center have developed a new screening approach to identify chemical compounds that can target and kill the stem cells responsible for creating deadly brain tumors.

Glioblastoma is one of the deadliest malignancies, typically killing patients within 12 to 18 months. These brain cancers consist of two kinds of cells: a larger, heterogeneous population of tumor cells and a smaller sub-population of stem cells, which are treatment-resistant. (more…)

“Drunkorexia:” A Recipe for Disaster

By Guest PostOctober 17, 2011Healthalcohol consumption, alcohol misuse, disordered eating, drinking rate, drunkorexia, eating disorder

MU study finds disordered eating combined with heavy drinking is common among college students

COLUMBIA, Mo. – It is well known that eating disorders are common among teens and college students. Heavy alcohol consumption is another well-known unhealthy habit of this age group. A new study from the University of Missouri shows that when college students combine these two unhealthy habits, their long-term health may be affected. “Drunkorexia” is a new term coined by the media to describe the combination of disordered eating and heavy alcohol consumption. (more…)

WHOI Teaming with Flatley Discovery Lab in Search for Effective Treatments for Cystic Fibrosis

By Guest PostOctober 13, 2011Health, Scienceantibiotics, biological and chemical processes of ocean microbes, cf, cftr, cftr gene, charlestown, chemical extracts, cystic fibrosis, cystic fibrosis trans-membrane conductance regulator, flatley discovery lab, fungi, gene, john flatley, marine actinomycetes, marine microbes, marine microbial extracts, membrane, microbes, microbial infection biofilm, mutation, phytoplankton, respiratory disease, richard fitzpatrick, sodium transport, susan k. avery, therapeutic agents for cystic fibrosis, tracy mincer, whoi, woods hole oceanographic institution

The Woods Hole Oceanographic Institution (WHOI) has signed a $1.18 million agreement with the Flatley Discovery Lab in Charlestown, Mass., to investigate and supply marine microbial extracts as possible treatments for cystic fibrosis (CF).

The life-shortening respiratory disease has eluded attempts at a cure, although researchers have been successful in some cases at adding years to a person’s lifespan, primarily through treatment with antibiotics. (more…)

Zinc’s Role in the Brain

By Guest PostOctober 13, 2011Health, Sciencechemical in synaptic vesicles, duke university, long-term potentiation, neuroscience, stores neurotransmitters, the role of zinc in the brain, university of toronto scarborough (utsc), xiao-an zhang, zinc, zinc’s function, zinc’s role in the brain, zx1

*Research gives insight into 50-year-old mystery – zinc important for learning and memory

TORONTO, ON – Zinc plays a critical role in regulating how neurons communicate with one another, and could affect how memories form and how we learn. The new research, in the current issue of Neuron, was authored by Xiao-an Zhang, now a chemistry professor at the University of Toronto Scarborough (UTSC), and colleagues at MIT and Duke University.

Researchers have been trying to pin down the role of zinc in the brain for more than fifty years, ever since scientists found high concentrations of the chemical in synaptic vesicles, a portion of the neuron that stores neurotransmitters. But it was hard to determine just what zinc’s function was. (more…)

Clinical Trial Uncovers Potential ‘Functional Cure’ for HIV/AIDS

By Guest PostOctober 12, 2011Healthantiviral effect, biallelic zfn-modification, ccr5 gene, clinical trial, dr. ronald mitsuyasu, functional cure for hiv/aids, highly active antiretroviral therapy (haart), interscience conference on antimicrobial agents and chemotherapy, non-responders, sangamo biosciences phase, sb-728-t, university of california, university of pennsylvania school of medicine

Data shows Correlation between New Therapeutic Approach, Viral Load Reduction

Data from a clinical trial involving UCLA researchers suggest that a new therapy may potentially serve as a “functional cure” for HIV/AIDS.

The therapy, called SB-728-T, involves the modification of both copies of a patient’s CCR5 gene, which encodes the major co-receptor used by HIV to infect immune system cells.

In the Sangamo BioSciences’ phase 1 trial, SB-728-T was given to HIV patients who were on highly active antiretroviral therapy (HAART) but were considered to be “non-responders” — that is, their CD4+ T-cell levels, a key measure of immune system health, remained low. The patients’ HAART therapy was interrupted when they received the SB-728-T therapy. (more…)

Category Archives: Health

*Research gives insight into 50-year-old mystery – zinc important for learning and memory

Data shows Correlation between New Therapeutic Approach, Viral Load Reduction