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Clinical Trial Uncovers Potential ‘Functional Cure’ for HIV/AIDS

Data shows Correlation between New Therapeutic Approach, Viral Load Reduction

Data from a clinical trial involving UCLA researchers suggest that a new therapy may potentially serve as a “functional cure” for HIV/AIDS.

The therapy, called SB-728-T, involves the modification of both copies of a patient’s CCR5 gene, which encodes the major co-receptor used by HIV to infect immune system cells.

In the Sangamo BioSciences’ phase 1 trial, SB-728-T was given to HIV patients who were on highly active antiretroviral therapy (HAART) but were considered to be “non-responders” — that is, their CD4+ T-cell levels, a key measure of immune system health, remained low. The patients’ HAART therapy was interrupted when they received the SB-728-T therapy. (more…)

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