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New Technique Targets Specific Areas of Cancer Cells with Different Drugs

By Guest PostJanuary 8, 2014Healthadriano bellotti, cancer cell, chapel hill, conventional treatment techniques, dox, doxorubicin, drugs, enzymes, jianping zhou, large scale manufacturing, nanoparticle, new technique, north Carolina, nucleus, programmed strategy, ran mo, specific area, state university, target, tianyue jiang, zhen gu

Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective. The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill.

“In testing on laboratory mice, our technique resulted in significant improvement in breast cancer tumor reduction as compared to conventional treatment techniques,” says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill. (more…)

Parasitic DNA proliferates in aging tissues

By Guest PostJanuary 5, 2014Healthaging tissues, cancerous tissue, cancerous tumors, cell culture, DNA, fruit fly drosophila, hepatocellular carcinoma, jill kreiling, john sedivy, journal aging, lymphoma, marco dececco, normal tissues, parasitic dna, replicative senescence, retrotransposable elements, robert reenan, rtes, stephen helfand

As mice age, cells in tissues such as the liver and skeletal muscle lose control over rogue sequences of DNA called “retrotransposable elements,” according to new research in the journal Aging. The elements, which may undermine health, could proliferate in old mice and were also abundant in cancerous tissue. A low-calorie diet, however, restrained their advance.

PROVIDENCE, R.I. [Brown University] — The genomes of organisms from humans to corn are replete with “parasitic” strands of DNA that, when not suppressed, copy themselves and spread throughout the genome, potentially affecting health. Earlier this year Brown University researchers found that these “retrotransposable elements” (RTE’s) were increasingly able to break free of the genome’s control in cultures of human cells. Now in a new paper in the journal Aging, they show that RTEs were increasingly able to break free and copy themselves in the tissues of mice as the animals aged. In further experiments the biologists showed that this activity was readily apparent in cancerous tumors, but that it also could be reduced by restricting calories. (more…)

Wer am Arbeitsplatz und zu Hause ständig sitzt

By Guest PostJanuary 5, 2014Healtharbeitsplatz, bewegung, das video, der koerper, einige tipps, gesund bleiben, infosperber, moebelhersteller varier furniture, staendig sitzt

Langes Sitzen ist widernatürlich. Der Körper braucht Bewegung, damit wir uns wohl fühlen und gesund bleiben. Einige Tipps.(english)

If your work or home life involves a lot of sitting, you may watch this 3-minute clip. (more…)

How a Concussion Can Lead to Depression Years Later

By Guest PostJanuary 4, 2014Healthashley fenn, brain cells, common antidepressants, concussion, depression, depressive symptoms, excessive inflammation, high alert cells, immune system, inflammation related, jonathan godbout, lipopolysaccharide, lps, microglia, multiple concussions, phillip popovich, primed state, secondary challenges, tbi, traumatic brain injury, yan huang

After brain injury, cells on ‘high alert’ prolong immune response, affecting behavior

COLUMBUS, Ohio – A head injury can lead immune-system brain cells to go on “high alert” and overreact to later immune challenges by becoming excessively inflammatory – a condition linked with depressive complications, a new animal study suggests.

The findings could help explain some of the midlife mental-health issues suffered by individuals who experience multiple concussions as young adults, researchers say. And these depressive symptoms are likely inflammation-related, which means they may not respond to common antidepressants. (more…)

TB bacteria mask their identity to intrude into deeper regions of lungs

By Guest PostJanuary 3, 2014Healthinfection killing cells, samples of tb, tb causing bacteria, tb cells, tb infections, tb pathogens, tuberculosis infections

TB-causing bacteria appear to mask their identity to avoid recognition by infection-killing cells in the upper airways. The bacteria call up more permissive white blood cells in the deeper regions of the lungs and hitch a ride inside them to get into the host’s body. (more…)

Mole Crowdsourcing: There could be an App for That

By Guest PostJanuary 1, 2014Healthandy j king, cancerous moles, clinical skin examinations, communication technology, decision-making, douglas grossman, jakob jensen, mole crowdsourcing, pattern, robert w gehl, skin cancer, texas tech university, united states, university of utah

University of Utah researchers identify new technique for identifying cancerous moles

Have you ever had a strange mole on your body and wondered if it was skin cancer? The best move is to schedule an appointment with a dermatologist, but many wait without realizing they could be dealing with melanoma.

Researchers at two universities – the University of Utah and Texas Tech University – have recently identified a new technique for handling this problem: Ask a crowd. (more…)

Many older Americans rely on people, devices, other strategies to get by

By Guest PostDecember 30, 2013Healthadapt to disability, daily life, older americans, public health intervention

ANN ARBOR — Only about a third of Americans ages 65 and older are fully able to take care of themselves and go about their daily lives completely independently, according to a new study published online in the American Journal of Public Health. (more…)

Genetic flaw in males triggers onset of liver cancer, diabetes

By Guest PostDecember 30, 2013Healthchin lee wu, common risk factor, diabetes, diseases, genetic flaw, glucose intolerance, hepatocellular carcinoma, hua xiao, liver cancer, males, mark williams, michigan state university, ncoa5 gene, onset, shenglan gao, therapeutic options, type 2 diabetes

Michigan State University researchers have uncovered a genetic deficiency in males that can trigger the development of one of the most common types of liver cancer and forms of diabetes.

The research, published in the online issue of Cancer Cell, found that when the NCOA5 gene, present in both men and women, was altered in male mice to a deficient level, a spontaneous reaction occurred producing cells that can lead to hepatocellular carcinoma, a type of liver cancer found to be two-to-four times more prevalent in men than women. (more…)

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