UA researchers have discovered that two separate defects combine to contribute to reduced T cell responses with aging.
Researchers at the University of Arizona College of Medicine – Tucson have found a key to understanding the aging immune system’s decreased response to infectious diseases, which remain among the leading causes of death in older adults.(more…)
Green space in towns and cities could lead to significant and sustained improvements in mental health, finds a new study published in the journal of Environmental Science & Technology.
Analysing data that followed people over a five year period, the research has found that moving to a greener area not only improves people’s mental health, but that the effect continues long after they have moved.
The findings add to evidence that suggests increasing green spaces in cities – such as parks and gardens – could deliver substantial benefits to public health. (more…)
Researchers have developed a technique for creating nanoparticles that carry two different cancer-killing drugs into the body and deliver those drugs to separate parts of the cancer cell where they will be most effective. The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill.
“In testing on laboratory mice, our technique resulted in significant improvement in breast cancer tumor reduction as compared to conventional treatment techniques,” says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill. (more…)
As mice age, cells in tissues such as the liver and skeletal muscle lose control over rogue sequences of DNA called “retrotransposable elements,” according to new research in the journal Aging. The elements, which may undermine health, could proliferate in old mice and were also abundant in cancerous tissue. A low-calorie diet, however, restrained their advance.
PROVIDENCE, R.I. [Brown University] — The genomes of organisms from humans to corn are replete with “parasitic” strands of DNA that, when not suppressed, copy themselves and spread throughout the genome, potentially affecting health. Earlier this year Brown University researchers found that these “retrotransposable elements” (RTE’s) were increasingly able to break free of the genome’s control in cultures of human cells. Now in a new paper in the journal Aging, they show that RTEs were increasingly able to break free and copy themselves in the tissues of mice as the animals aged. In further experiments the biologists showed that this activity was readily apparent in cancerous tumors, but that it also could be reduced by restricting calories. (more…)
After brain injury, cells on ‘high alert’ prolong immune response, affecting behavior
COLUMBUS, Ohio – A head injury can lead immune-system brain cells to go on “high alert” and overreact to later immune challenges by becoming excessively inflammatory – a condition linked with depressive complications, a new animal study suggests.
The findings could help explain some of the midlife mental-health issues suffered by individuals who experience multiple concussions as young adults, researchers say. And these depressive symptoms are likely inflammation-related, which means they may not respond to common antidepressants. (more…)
TB-causing bacteria appear to mask their identity to avoid recognition by infection-killing cells in the upper airways. The bacteria call up more permissive white blood cells in the deeper regions of the lungs and hitch a ride inside them to get into the host’s body.(more…)
University of Utah researchers identify new technique for identifying cancerous moles
Have you ever had a strange mole on your body and wondered if it was skin cancer? The best move is to schedule an appointment with a dermatologist, but many wait without realizing they could be dealing with melanoma.
Researchers at two universities – the University of Utah and Texas Tech University – have recently identified a new technique for handling this problem: Ask a crowd. (more…)