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Clever chemistry and a new class of antibiotics

By Guest PostJanuary 22, 2014Health, Scienceacyldepsipeptides, adeps, antibacterial drug, antibiotics, attack bacteria, bacterial infection, barrel shaped protein, brown university, cell membrane, clever chemistry, clpp, dangerous bacteria, e faecalis, intramolecular hydrogen bonds, jason sello, karl schmitz, mice, MIT, molecules, new class, potent, rat, resistance to antibiotics, robert sauer, strong bonds, stronger hydrogen bonds

A new class of molecules called acyldepsipeptides — ADEPs — may provide a new way to attack bacteria that have developed resistance to antibiotics. Researchers at Brown and MIT have discovered a way to increase the potency of ADEPs by up to 1,200 times. Their findings appear in the Journal of the American Chemical Society.

PROVIDENCE, R.I. [Brown University] — As concerns about bacterial resistance to antibiotics grow, researchers are racing to find new kinds of drugs to replace ones that are no longer effective. One promising new class of molecules called acyldepsipeptides — ADEPs — kills bacteria in a way that no marketed antibacterial drug does — by altering the pathway through which cells rid themselves of harmful proteins. (more…)

Scandalous bodies and our relationship with food

By Guest PostJanuary 21, 2014Culture, Healthalcohol consumption, attitude, body shape, corinna wagner, extravagant lifestyle, georgian period, goddesses of health, government, honest british, king george, late georgian england, medicine, mid victorian period, model, modern day phenomenon, monarchy, mulligatawny soup, obesity, over indulgence, pathological bodies, persian delicacies, physical perfection, political culture, self control, self discipline, the english malady, thomas king chambers, university of exeter, victorian, vitriolic public condemnation

Attitudes toward over-indulgence, obesity and body shape were being hotly debated and used for political purposes as early as the 19^th century, a new book claims. ‘Pathological Bodies’, by Dr Corinna Wagner from the University of Exeter, shows that body consciousness is not just a modern-day phenomenon.

Instead, medical warning about excessive eating and drinking, and public attitudes about self-control and discipline emerged more than 250 years ago, when the perceived decadence of the Georgian period gave way to the more moderate and austere approach adopted by the Victorians. (more…)

Data suggest new class of drug may be potent against genital herpes

By Guest PostJanuary 21, 2014Healthacyclovir, amalia magaret, americans, anal region, anna wald, blood, christine johnston, data, drug, drug resistance, famciclovir, famvir, genital area, genital herpes, genital hsv2 infection, genital lesions, herpes simplex virus, hsv 2, hsv dna polymerase, lawrence corey, lips, meei li huang, monkey, new class, pain, pritelivir, signs, skin abnormality, sore, stacy selke, toxicology study, valacyclovir, valtrex, viral enzyme, zovirax

A new drug, called pritelivir, may offer a new treatment option for patients with genital herpes, a new industry-sponsored – study led by University of Washington researchers has found.

The study appears in this week’s issue of the New England Journal of Medicine. The lead author is Anna Wald, M.D., professor of medicine, epidemiology, and laboratory medicine, and medical director at the Virology Research Clinic at the University of Washington. Other UW coauthors include Dr. Amalia Magaret, Dr. Christine Johnston, Dr. Lawrence Corey, Dr. Meei-Li Huang and Stacy Selke. (more…)

Mystery Solved: How Nerve Impulse Generators Get Where They Need to Go

By Guest PostJanuary 20, 2014Health, Scienceankyrin g, axons, body, brain, cell, central nervous system, chen gu, disease, electrical signaling, joshua barry, key protein, kinesin 1, molecular motor, motor protein, multiple sclerosis, mystery solved, nerve cell bodies, nerve impulse, nerve impulse generators, neurological disorders, neuron, nodes of ranvier, ohio state university, parkinson's, peter jukkola, potassium ion channel, protein, sodium ion channel, spinal cord, symptom, yuanzheng g

Study identifies essential molecule for transport of protein from neuron cell body to axon

COLUMBUS, Ohio – Scientists have solved a longstanding mystery of the central nervous system, showing how a key protein gets to the right spot to launch electrical impulses that enable communication of nerve signals to and from the brain.

Nerve impulses are critical because they are required for neurons to send information about senses, movement, thinking and feeling to other cell types in the neural circuitry. And an impulse is not fired up just once; it is initiated and then must be repeatedly transmitted along axons – long, slender extensions of nerve cell bodies – to keep the nervous system’s messages stable during their rapid travel. (more…)

Trial to test using ultrasound to move kidney stones

By Guest PostJanuary 17, 2014Healthanimal model, barbrina dunmire, device, high energy ultrasound, humans, inversion, jonathan harper, lithotripsy, michael bailey, move kidney stones, natural means, percussion, project, prototype, reduce pain, shock wave ultrasound, technique, test, treatment times, trial, ultrasound, united states, university of washington, urologists, uw medicine

Almost one in 10 people will someday experience a kidney stone, which creates what is described as the most intense pain imaginable. This increasingly common condition leads to hundreds of thousands of surgeries in the United States each year.

A new device developed at the University of Washington would let doctors use ultrasound to move kidney stones inside the body and help them pass by natural means. (more…)

Minorities and poor have more advanced thyroid cancers when diagnosed, UCLA study shows

By Guest PostJanuary 15, 2014Healthavital harari, black patients, disease, earlier treatments, economic brackets, michael yeh, minority patients, morbidity, mortality risk, ning li, racial groups, socioeconomic status, survival rates, thyroid cancer, ucla researchers

Black patients fare worst; Asians, Hispanics survive longest with disease

UCLA researchers have found that minority patients and those of lower socioeconomic status are far more likely to have advanced thyroid cancer when they are diagnosed with the disease than white patients and those in higher economic brackets.

In one of the most comprehensive studies of its kind, the UCLA team looked at nearly 26,000 patients with well-differentiated thyroid cancer and analyzed the impact of race and socioeconomic factors on the stage of presentation, as well as patient survival rates. (more…)

Racism May Accelerate Aging in African American Men

By Guest PostJanuary 14, 2014Healthafrican american men, african americans, aging, anti black attitudes, biological age, biological level, biomarker, cellular level, chromosome, chronological age, david h chae, disease risk, gene h brody, indicator, leukocyte telomere length, physiological stress, racial discrimination, racism, sequences of dna, systemic aging, tear, telomere, university of maryland, wear

UMD-led study is first to link racism-related factors and cellular age

COLLEGE PARK, Md. – A new University of Maryland-led study reveals that racism may impact aging at the cellular level. Researchers found signs of accelerated aging in African American men who reported high levels of racial discrimination and who had internalized anti-Black attitudes. Findings from the study, which is the first to link racism-related factors and biological aging, are published in the American Journal of Preventive Medicine.

Racial disparities in health are well-documented, with African Americans having shorter life expectancy, and a greater likelihood of suffering from aging-related illnesses at younger ages compared to whites. Accelerated aging at the biological level may be one mechanism linking racism and disease risk. (more…)

Nature Medicine

By Guest PostJanuary 14, 2014Healthhiv persistence, hiv therapy, hiv treatment protocol, infected tscm cells, nature medicine

Engineering professor co-authors Nature Medicine paper on HIV

Ryan Zurakowski, assistant professor of electrical and computer engineering at the University of Delaware, is co-author of a paper appearing in Nature Medicine on Jan. 12 highlighting the role of T-cells in HIV. (more…)

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