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Strategie zur Reduktion von Nebenwirkungen in der modernen Krebstherapie

By Guest PostOctober 1, 2014Healthbasic elementary particles, berechnen, cevns, cobalt, coherent elastic, color codes, datenbus, de la parra, finding neutrinos, hendrik poulsen nautrup, internal power, matthew green, neutrino nuclear scattering, proteine, quanteninformation, quantenspeicher, romantic vibes, special, stimuate, stoerungen, universitaet wien, vacancy posting

Einem interdisziplinären ForscherInnenteam der Universität Wien (Institut für Anorganische Chemie) und der Medizinischen Universität Wien (Institut für Krebsforschung) ist es gelungen, eine neue Strategie zur Reduktion der oft schweren Nebenwirkungen für eine wichtige Klasse moderner Krebstherapeutika (Tyrosinkinase-Inhibitoren) zu entwickeln. Der Wirkstoff soll sich möglichst selektiv auf den bösartigen Tumor beschränken.

Das Auftreten von schweren Nebenwirkungen sowie Resistenzentwicklung gehören zu den größten Problemen der modernen Krebstherapie. Auch neueste zielgerichtete Krebsmedikamente, wie z.B. die Tyrosinkinase-Inhibitoren Tarceva (R) oder Sutent (R) sind von diesen Problemen betroffen, was sogar zum Therapieabbruch führen kann. Die Wirkung dieser Klasse von Inhibitoren beruht auf einer gezielten Hemmung von Proteinen, die in Krebszellen überaktiviert sind und das krankhafte Zellwachstum antreiben. Jedoch stellte sich in der klinischen Praxis heraus, dass, bedingt durch die physiologischen Funktionen dieser Proteine im gesunden Gewebe, die Hemmung zu schweren Nebenwirkungen führen kann. Daher besteht für diese vielversprechenden neuen Therapeutika akuter Bedarf nach Strategien, ihre Wirkung selektiver auf den bösartigen Tumor zu beschränken. (more…)

Dodging dots helps explain brain circuitry

By Guest PostSeptember 30, 2014Healthastrophysical particles, brown university, carlos aizenman, derek schaeffer, detmar meurers, diamond mine, eastern russia, general model, guglielmo tino, inhibitory neurons, kaiserschnitt risiko, karin berendes, largest excavated hole, magnetosonic mach number, mirny mine, neuroscientists, omega ep, open pit, schlechte note, schulbuch, supersonic shock waves, tadpoles

In a new study, Brown University neuroscientists looked cell-by-cell at the brain circuitry that tadpoles, and possibly other animals, use to avoid collisions. The study produced a model of how individual inhibitory and excitatory neurons can work together to control a simple behavior.

PROVIDENCE, R.I. [Brown University] — A neuroscience study provides new insight into the primal brain circuits involved in collision avoidance, and perhaps a more general model of how neurons can participate in networks to process information and act on it. (more…)

Diabolical duo: Known breast cancer gene needs a partner to initiate and spread tumors

By Guest PostSeptember 27, 2014Health2 grad grenze, allen lalonde, anti vietnam war, cancer cell, chemotherapy, conquer global pandemics, fusion genomics, helga weisz, metastasis, mohammad qadir, peter paul pichler, princeton university, produktion von zement, schimmel, schimmelpilze, stadtgrenze, stahl, susanne zeilinger migsich, trichoderma, types of cancer, un klimagipfel, vancouver bc, yibin kang

A study led by Princeton University researchers has revealed that the gene Metadherin — which is implicated in promoting the spread of breast cancer tumors — only stimulates tumor growth when the protein made by the gene interacts with a second protein known as SND1. (more…)

Robot-assisted technique improves surgeons’ ability to remove small kidney cancer tumors

By Guest PostSeptember 26, 2014Healthamericans, blatt, christiane nuesslein volhard, ct scan, disney world, european urology, jim hu, kidney cancer, marja timmermans, muster, nanomagnete, pablo escobar, patricia hernandez, remove, zellkommunikation

UCLA-led study also finds that the approach may shorten surgeries, which could reduce risk of complications

Roughly 50,000 Americans are diagnosed with kidney cancer each year. Most of them have small tumors that doctors discover while screening for other health problems. (more…)

How to rejuvenate ageing immune cells

By Guest PostSeptember 22, 2014Healthautophagy, bbsrc, cancer, fleischfressende wasserschlaeuchen, immunity, infections, lung cancer patients, metabolism, microfluidic chips, molecule, nutrition, recycling, rhonda jack, rishindra reddy, t cells, t lymphocytes, tumor removal surgery, vasudha murlidhar

Researchers from UCL have demonstrated how an interplay between nutrition, metabolism and immunity is involved in the process of ageing.

The two new studies, supported by the Biotechnology and Biological Sciences Research Council (BBSRC), could help to enhance our immunity to disease through dietary intervention and help make existing immune system therapies more effective. As we age our immune systems decline. Older people suffer from increased incidence and severity of both infections and cancer. In addition, vaccination becomes less efficient with age. (more…)

UCLA to develop ‘brain prosthesis’ to help brain-injured patients recover memory

By Guest PostSeptember 20, 2014Healthalzheimer's disease, avian egg shape, brain cells, brain-injured patients, claire spottiswoode, clinical trial, develop, ebola impfstoff, ebola viren, ee hou yong, egg shape, eggxtractor, electronics, entorhinal cortex, epilepsy, henry samueli school, itzhak fried, mary caswell stoddard, mayank mehta, nanthia suthana, neurobiology, new hypothesis, projects, richtige dosierung, selidji agnandji, ucla

As part of a major federal initiative, UCLA has been awarded $15M to create a wireless, implantable device that could restore memory to millions

UCLA has been tapped by the Defense Advanced Research Projects Agency to spearhead an innovative project aimed at developing a wireless, implantable brain device that could help restore lost memory function in individuals who have suffered debilitating brain injuries and other disorders. (more…)

All HIV not created equal: Scientists believe they can identify which viruses cause infection

By Guest PostSeptember 15, 2014Health, Scienceamy schmitz, boost in brainpower, can apes talk, ceramic nanofiber, colin rule, dieter steklis, heterogeneous, hiv, hiv virus, identify, nature nanotechnology, the new handshake, university of michigan

ANN ARBOR — HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others.

Yet, despite the breadth of infectivity, roughly 76 percent of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus. (more…)

Study reveals scale of the sexual exploitation of boys

By Guest PostSeptember 15, 2014Healthabuse of boys, child sexual exploitation, male victims, sexual exploitation

Research carried out by UCL Security and Crime Science (UCL Engineering) and NatCen, funded by the Nuffield Foundation and supported by Barnardo’s, underlines the dangers of underestimating the impact of child sexual exploitation on boys and young men. (more…)

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