For certain kinds of cancer, the most effective therapy does not use x-rays or gamma rays but beams of ions, the electrically charged cores of atoms, including hydrogen ions (protons) and heavier ions such as carbon and neon.
About the image: Beams of heavy ions can target hard-to-reach tumors with great accuracy and with minimal damage to surrounding tissues. Heidelberg Ion-Beam Therapy Center. Image credit: Berkeley Lab (more…)
John Tanner, who also teaches chemistry in the College of Arts and Science, is studying Aspergillus fumigatus. Image credit: University of Missouri
COLUMBIA, Mo. – If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.
Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two “crime scenes”: in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the “kissing bug” for the red welts left on the victims’ faces after being bitten in his or her sleep.
“My job is to figure out what the enzyme looks like using X-ray diffraction,” Tanner said. “This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens.” (more…)
Marc Therrien. Image credit: University of Montreal
Researchers at the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal have identified a new mechanism controlling the transmission of an abnormal signal at the origin of several cancers. In an article published in the journal Cell, Marc Therrien’s team explains the recent discovery of a protein complex that controls the RAS/MAPK signalling pathway, responsible for some of the deadliest cancers, including pancreatic, colon and lung cancers, and melanomas. This regulating mechanism could prove to be a promising therapeutic target for the treatment of these diseases. The study conducted on the drosophila model organism is to be verified in humans in a forthcoming step. (more…)
Lowering levels of a key protein involved in regulating learning and memory—STtriatal-Enriched tyrosine Phosphatase (STEP)—reversed cognitive deficits in mice with Alzheimer’s disease, Yale School of Medicine researchers report in the October 18 issue of Proceedings of the National Academy of Sciences. (more…)
COLUMBIA, Mo. – For some women, the effects of breast cancer, the most common cancer affecting women, do not end when they leave the hospital. Now, researchers in the University of Missouri School of Health Professions have studied the lives of breast cancer patients following chemotherapy and found that their environments and available support systems help determine the quality of their lives.
“A lot of times people get mentally and emotionally ready to deal with chemotherapy and they receive a lot of support during that time,” said Stephanie Reid-Arndt, an assistant professor of health psychology in the School of Health Professions. “Then they go home and everyone feels like it’s over, but the patients still have worries and fears about the changes they’ve been through and what it means for the future.” (more…)
Mandi Schwartz. Image credit: Yale University
After spending six days in intensive care fighting her way through another life-threatening condition, Yale hockey player Mandi Schwartz got some much-needed positive news in her battle with cancer on Friday.
Tests have confirmed that, 23 days after her stem cell transplant, engraftment — i.e., the birth of her new immune system — has taken place. This marks a major positive step, but challenges still remain for the Yale women’s ice hockey center.
“The weeks since the transplant have been physically tough on Schwartz, and there have been several scary moments, but she continues to fight,” says her mother, Carol. “She remains focused on her goal of overcoming every challenge and getting her health back. We are all inspired by the support we have received from so many different people throughout this process.” (more…)
ANN ARBOR, Mich.— A drug marketed to grow bone in osteoporosis patients also works to heal bone wounds in gum disease patients, a University of Michigan study suggests. (more…)
University of Colorado at Boulder Professor Douglas R. Seals has amassed scientific evidence indicating that exercise, weight loss, 
good nutrition and salt restriction can cut your chances of getting cardiovascular disease, the United States’ No. 1 killer.
But Seals knows that exhorting people to exercise and lose weight, no matter how well the case is buttressed with data, will only go so far. So Seals’ laboratory has begun researching “nutraceuticals,” food extracts or vitamin supplements that could mimic the effects of a healthful lifestyle. (more…)
