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Genome-wide Atlas of Gene Enhancers in the Brain On-line

By Guest PostFebruary 6, 2013Scienceautism, axel visel, basal ganglia, berkeley lab, biological functions, brain on line, cerebral cortex, cerebrum, chip seq studies, chromatin immunoprecipitation, cognition, collection of data, dalit may, dna basepairs, dna elements, embryonic forebrain, emotion, epilepsy, evolution, gene, gene enhancers, gene regulating elements, gene regulatory functions, genetic mutations, genome wide atlas, gray matter, hani girgis, human brain, human diseases, junk dna, leila taher, molecular toolbox, motor functions, neurological disorders, non coding mutation, olga golonzhka, protein coding genes, schizophrenia, sequences of dna, telencephalon

Collaboration Led by Berkeley Lab Researchers Creates High-Resolution Map of Gene Regulatory Elements in the Brain

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

“Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science,” says Axel Visel, a geneticist with Berkeley Lab’s Genomics Division. “We’ve created a genome-wide digital atlas of gene enhancers in the human brain – the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders.” (more…)

Mammalian Brain Knows Where It’s at

By Guest PostDecember 8, 2012Sciencebehavior, brain, brain injury, brown university, conventional wisdom, depression, disease, egocentric movement, electrical activity, fish sculpture, frequency, hippocampus, humans, journal, location, memory, neuron, neuropsychiatric diseases, neuroscientist, object, omar ahmed, parahippocampal cortex, pattern, phc, por, postrhinal cortex, primate neuroanatomy, rebecca burwell, region, rhythm, schizophrenia, sharon furtak, Space, spiking, theta, treat

A new study in the journal Neuron suggests that the brain uses a different region than neuroscientists had thought to associate objects and locations in the space around an individual. Knowing where this fundamental process occurs could help treat disease and brain injury as well as inform basic understanding of how the brain supports memory and guides behavior.

PROVIDENCE, R.I. [Brown University] — Where are you?

Conventional wisdom in brain research says that you just used your hippocampus to answer that question, but that might not be the whole story. The context of place depends on not just how you got there, but also the things you see around you. A new study in Neuron provides evidence that a different part of the brain is important for understanding where you are based on the spatial layout of the objects in that place. The finding, in rats, has a direct analogy to primate neuroanatomy. (more…)

More Sophisticated Wiring, Not Just a Bigger Brain, Helped Humans Evolve Beyond Chimps

By Guest PostAugust 26, 2012Scienceamino acids, autism, bipolar syndrome, brain disease, brain region, brain tissue, cellular protein, chimp, chimp brain, chimpanzee, circadian rhythm, clock, daniel geschwind, DNA, expression, foxp1, foxp2, frontal cortex, frontal lobe, function, gene manufacture, genevieve konopka, genome, hippocampus, human, human brain, human evolution, human gene, hypothesis, jeremy davis turak, kellen winden, plasticity, schizophrenia, striatum, tara friedrich, ucla

Human and chimp brains look anatomically similar because both evolved from the same ancestor millions of years ago. But where does the chimp brain end and the human brain begin?

A new UCLA study pinpoints uniquely human patterns of gene activity in the brain that could shed light on how we evolved differently than our closest relative. The identification of these genes could improve understanding of human brain diseases like autism and schizophrenia, as well as learning disorders and addictions.

The research appears Aug. 22 in the advance online edition of the journal Neuron. (more…)

International Team Uncovers New Genes That Shape Brain Size, Intelligence

By Guest PostApril 16, 2012Scienceadenine, alzheimer's disease, arthur toga, australia, bad gene, barbara franke, bigger brain, bipolar disorder, brain size, brain study, centers, cytosine, dementia, depression, derrek hibar, disorder, DNA, Europe, gene, genetic variant, geneticist, guanine, hmga2, human gene, intelligence, iq test, jason stein, margaret wright, memory, mental illnesses, neda jahanshad, nick martin, North America, paul thompson, project enigma, rita cantor, rudy senstad, schizophrenia, thymine

*UCLA-launched partnership identifies genes that boost or lessen risk of brain atrophy, mental illness, Alzheimer’s disease*

In the world’s largest brain study to date, a team of more than 200 scientists from 100 institutions worldwide collaborated to map the human genes that boost or sabotage the brain’s resistance to a variety of mental illnesses and Alzheimer’s disease.

Published April 15 in the advance online edition of the journal Nature Genetics, the study also uncovers new genes that may explain individual differences in brain size and intelligence. (more…)

Tuning out: How Brains Benefit From Meditation

By Guest PostNovember 26, 2011Health, Sciencealzheimer's disease, anxiety, areas of brain, autism, beta amyloid plaques, brain imaging study, cope with cancer, daydreaming, default mode network, experienced meditators, functional magnetic resonance imaging scans, health problems, hedy kober, how meditation works, jeremy r gray, judson a brewer, medial prefrontal, meditation, meditation techniques, patrick d worhunsky, posterior cingulate cortex, prevent psoriasis, psychiatric disorders, schizophrenia, switch off

Experienced meditators seem to be able switch off areas of the brain associated with daydreaming as well as psychiatric disorders such as autism and schizophrenia, according to a new brain imaging study by Yale researchers.

Meditation’s ability to help people stay focused on the moment has been associated with increased happiness levels, said Judson A. Brewer, assistant professor of psychiatry and lead author of the study published the week of Nov. 21 in the Proceedings of the National Academy of Sciences. Understanding how meditation works will aid investigation into a host of diseases, he said. (more…)

Does Sex Matter? It May When Evaluating Mental Status

By Guest PostNovember 20, 20101 commentHealth, Scienceadrianna mendrek, alzheimer, brain abnormalities, brain function, estrogen, fmri, magnetic resonance imaging, mental disorder, schizophrenia, schizophrenics, sex, sex differences, sex hormones, symptomatology, testosterone

Adrianna Mendrek. Image credit : University of Montreal

Schizophrenia is a mental disorder that differs between the sexes in terms of age at onset, symptomatology, response to medication, and structural brain abnormalities. Now, a new study from the Université de Montréal shows that there is gender difference between men and women’s mental ability – with women performing better than men. These findings, published recently in, Schizophrenia Research, have implications for the more than 300 000 affected Canadians.

“We are the first to report sex differences in brain function of schizophrenics,” says Université de Montréal professor, Adrianna Mendrek a researcher at the Centre de Recherche Fernand-Seguin, Hospital Louis-H Lafontaine. “We chose to study a task involving mental rotation of a three dimensional image because in healthy men and women, this consistently elicits differences in terms of reaction time and performance accuracy.” (more…)

Nicotine May Play Key Role in Promising Alzheimer’s Therapy

By Guest PostOctober 13, 2010Health, Sciencea-beta, alpha7 nicotinic acetylcholine receptor, alpha7 receptor, alzheimer, angela lee, bace-1 knockouts, bace1, brain nicotine receptors, calcium uptake, disease, enzyme, fiona laird, hey kyoung lee, hui wang, lihua song, neurological disorder, neurons, neuroscientists, neurotransmitters, nicotine, normal brain function, peptide, philip c wong, schizophrenia, sixth-leading cause of death, united states, university of maryland

COLLEGE PARK, Md. — A team of neuroscientists has discovered important new information in the search for an effective treatment for Alzheimer’s disease, the debilitating neurological disorder that afflicts more than 5.3 million Americans and is the sixth-leading cause of death in the United States. Hey-Kyoung Lee , associate professor in the University of Maryland Department of Biology, and her research team have shown that they may be able to eliminate debilitating side effects caused by a promising Alzheimer’s drug by stimulating the brain’s nicotine receptors. (more…)

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