Tag Archives: microbes

Specific microbes in digestive tract can boost success for cancer immunotherapy

In the Jan. 5 issue of Science, researchers from the University of Chicago Medicine show that specific strains of commensal bacteria—the swarms of microorganisms naturally dwelling in the intestines—can improve the response rate to immunotherapy for patients being treated for advanced melanoma. (more…)

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Dirty, Crusty Meals Fit for (Long-Dormant) Microbes

In deserts and other arid lands, microbes often form very thin top layers on soil known as biocrusts, which behave a bit like Rip Van Winkle. He removed himself from a stressful environment by sleeping for decades, and awoke to a changed world; similarly, the biocrust’s microbes lie dormant for long periods until precipitation (such as a sudden downpour) awakens them. Understanding more about the interactions between the microbial communities—also called “microbiomes”—in the biocrusts and their adaptations to their harsh environments could provide important clues to help shed light on the roles of soil microbes in the global carbon cycle. (more…)

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Boosting Biogasoline Production in Microbes

Joint BioEnergy Institute Researchers Combine Systems Biology with Genetic Engineering to Improve Production of Isopentenol in E.Coli

In the on-going effort to develop advanced biofuels as a clean, green and sustainable source of liquid transportation fuels, researchers at the U.S. Department of Energy (DOE)’s Joint BioEnergy Institute (JBEI) have identified microbial genes that can improve both the tolerance and the production of biogasoline in engineered strains of Escherichia coli. (more…)

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New Insight into an Emerging Genome-Editing Tool

Berkeley Researchers Show Expanded Role for Guide RNA in Cas9 Interactions with DNA

The potential is there for bacteria and other microbes to be genetically engineered to perform a cornucopia of valuable goods and services, from the production of safer, more effective medicines and clean, green, sustainable fuels, to the clean-up and restoration of our air, water and land. Cells from eukaryotic organisms can also be modified for research or to fight disease. To achieve these and other worthy goals, the ability to precisely edit the instructions contained within a target’s genome is a must. A powerful new tool for genome editing and gene regulation has emerged in the form of a family of enzymes known as Cas9, which plays a critical role in the bacterial immune system. Cas9 should become an even more valuable tool with the creation of the first detailed picture of its three-dimensional shape by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley. (more…)

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Google, Intel Founders Support Undersea Research by UMass Amherst Microbiologist

AMHERST, Mass. – When microbiologist James Holden of the University of Massachusetts Amherst launches new studies next month of the microbes living deep in the cracks and thermal vents around an undersea volcano, for the first time in his 25-year career his deep-sea research will not be funded by a government source.

Instead, Holden will be funded by philanthropists committed to supporting oceanographic research: The Gordon and Betty Moore Foundation started by the co-founder of Intel and his wife, and the Schmidt Ocean Institute (SOI), started by Eric Schmidt of Google and his wife, Wendy. The Moores’ foundation is dedicated to advancing environmental conservation and scientific research, while the SOI supports oceanographic research projects that “help expand the understanding of the world’s oceans through technological advancements, intelligent observation and analysis, and open sharing of information.”  (more…)

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Ecological forces structure your body’s personal mix of microbes

Environmental conditions have a much stronger influence on the mix of microbes living in various parts of your body than does competition between species. Instead of excluding each other, microbes that fiercely compete for similar resources are more likely to cohabit in the same individual.

This phenomenon was discovered in a recent study of the human microbiome – the vast collection of our resident bacteria, fungi, and other tiny organisms. (more…)

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