UCLA researchers discover new point of attack for drug therapy
Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.
For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)
ANN ARBOR — Although women drivers now outnumber male motorists, men still account for the majority of the driving on America’s roads—albeit at a declining rate, says a University of Michigan researcher.
Using data from the Federal Highway Administration, Michael Sivak, a research professor at the U-M Transportation Research Institute, examined changes in the gender demographics of U.S. drivers from 1963 to 2010. (more…)
COLLEGE PARK, Md. – The so-called “fiscal cliff” has already begun dampening the U.S. economy – even before it officially kicks in – and by year’s end will have cut 2012 GDP an estimated six-tenths of one percent, says a new study conducted by researchers at the University of Maryland’s Interindustry Forecasting Project (Inforum).
The study, called Fiscal Shock: America’s Economic Crisis, is one of the first to look beyond the first year effects of the combined federal spending cuts and tax increases. It projects an escalating impact into 2014 and beyond, as “multiplier” effects of fiscal contraction kick in. (more…)
Jack Turner, UW assistant professor of political science, is the author of “Awakening to Race: Individualism and Social Consciousness in America,” published this month by University of Chicago Press. He answered a few questions about his book for UW Today.
What’s the central concept behind “Awakening to Race”?
The book addresses the challenge of racial justice by asking, “What does it mean to be a self-aware human being? What does it mean to be awake to reality?”
In part, it means confronting the worst aspects of ourselves and our lives. Being awake to reality in the United States means confronting the ways America’s history of slavery, Jim Crow and white supremacy still shapes the present — the opportunities we have or we lack, the confidence we have in ourselves or fail to have in others, the ways our chances for success are still color coded. (more…)
There’s an old adage (with several variations) that California has four seasons: earthquake, fire, flood and drought. While Californians happily cede the title of Hurricane Capital of America to U.S. East and Gulf coasters, every once in a while, Mother Nature sends a reminder to Southern Californians that they are not completely immune to the whims of tropical cyclones. Typically, this takes the form of rainfall from the remnants of a tropical cyclone in the eastern Pacific, as happened recently when the remnants of Hurricane John brought rain and thunderstorms to parts of Southern California. But could a hurricane ever make landfall in Southern California?
The answer, as it turns out, is yes, and no. While there has never been a documented case of a hurricane making landfall in California, the Golden State has had its share of run-ins and close calls with tropical cyclones. In fact, California has been affected by at least a few tropical cyclones in every decade since 1900. Over that timeframe, three of those storms brought gale-force winds to California: an unnamed California tropical storm in 1939, Kathleen in 1976 and Nora in 1997. But the primary threat from California tropical cyclones isn’t winds or storm surge. It’s rainfall — sometimes torrential — which has led to flooding, damage and, occasionally, casualties. (more…)
Katherine Boo talks of hope and struggle in Annawadi, India
Pulitzer Prize-winning author Katherine Boo found that despite having to struggle daily to survive, the people who live in Annawadi, India, also share the common hopes, dreams and aspirations of people everywhere in seeking to better themselves and their children.
Boo, the author of Behind the Beautiful Forevers: Life, Death and Hope in a Mumbai Undercity, shared her experiences as a journalist reporting from the Mumbai slum during a 2012 University of Delaware First Year Common Reader program presentation held Wednesday, Oct. 10, in Mitchell Hall. (more…)
A lot is up for grabs this November in America—the presidency of the United States, for one. Not to mention a third of U.S. Senate seats, all seats in the U.S. House, and state-level amendments on issues ranging from voter ID to same-sex marriage (Minnesota has both on the ballot).
But almost six million Americans will sit this one out because of something they’ve done. They’re felons—perpetrators, at some point in their lives, of a serious crime. (more…)
As part of a commitment to create opportunities for 300 million youth around the world during the next three years, Microsoft announces support for five national U.S. nonprofits that focus on youth causes. Here’s a look at how these organizations are making a difference.
On the surface, the nonprofit grants aim to bolster programs that help youth learn important 21st-century skills, find jobs and connect with caring adult mentors. (more…)
