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Diagnostic Technique Uses Immune Cell DNA

By Guest PostJuly 10, 2012Scienceafrican american, bladder cancer, blood samples, brock christensen, brown university, carmen marsit, cd4, cell carcinoma, cell membrane, chemical alteration, devin koestler, DNA, granulocyte leukocytes, immune cell, karl kelsey, leukocytes, methylation, ovarian cancer, t lymphocytes

By looking at signature chemical differences in the DNA of various immune cells called leukocytes, scientists have developed a way to determine their relative abundance in blood samples. The relative abundance turns out to correlate with specific cancers and other diseases, making the technique, described in two recent papers, potentially valuable not only for research but also for diagnostics and treatment monitoring.

PROVIDENCE, R.I. [Brown University] — When a person is sick, there is a tell-tale sign in their blood: a different mix of the various types of immune cells called leukocytes. A group of scientists at several institutions including Brown University has discovered a way to determine that mix from the DNA in archival or fresh blood samples, potentially providing a practical new technology not only for medical research but also for clinical diagnosis and treatment monitoring of ailments including some cancers. (more…)

Jekyll and Hyde Bacteria Aids or Kills, Depending on Chance

By Guest PostJuly 10, 2012Scienceantibiotic tolerance, bacterial insecticide, chronic infections, innocuous bacteria

EAST LANSING, Mich. — Living in the guts of worms are seemingly innocuous bacteria that contribute to their survival. With a flip of a switch, however, these same bacteria transform from harmless microbes into deadly insecticides. (more…)

Astronomers Discover Houdini-Like Vanishing Act in Space

By Guest PostJuly 9, 2012Sciencecosmic dust disappearance, cosmic vanishing act, disappearing cosmic dust, dust rings

Astronomers report a baffling discovery never seen before: An extraordinary amount of dust around a nearby star has mysteriously disappeared. (more…)

Mars Panorama: Next Best Thing to Being There

By Guest PostJuly 7, 2012Sciencearizona state university, cornell university, endeavour crater, greeley haven, jim bell, mars exploration rover, mars odyssey orbiter, mars panorama, mars pathfinder, martian winter, NASA, opportunity, pancam, ron greeley, steve squyres

PASADENA, Calif. — From fresh rover tracks to an impact crater blasted billions of years ago, a newly completed view from the panoramic camera (Pancam) on NASA’s Mars Exploration Rover Opportunity shows the ruddy terrain around the outcrop where the long-lived explorer spent its most recent Martian winter.

This scene recorded from the mast-mounted color camera includes the rover’s own solar arrays and deck in the foreground, providing a sense of sitting on top of the rover and taking in the view. Its release this week coincides with two milestones: Opportunity completing its 3,000th Martian day on July 2, and NASA continuing past 15 years of robotic presence at Mars. Mars Pathfinder landed July 4, 1997. NASA’s Mars Global Surveyor orbiter reached the planet while Pathfinder was still active, and Global Surveyor overlapped the active missions of the Mars Odyssey orbiter and Opportunity, both still in service. (more…)

Motion Sensors Detect Horse Lameness Earlier Than Veterinarians, MU Study Finds

By Guest PostJuly 5, 2012Nature, Scienceailment, equine veterinarian, frequency, horse, human eye, kevin keegan, lameness, lameness locator, meghan mccracken, sensitivity level, shoes on horse

MU-developed “Lameness Locator” system helps diagnose lameness sooner, makes treatment easier

COLUMBIA, Mo. — The most common ailment to affect a horse is lameness. A University of Missouri equine veterinarian has developed a way to detect this problem using a motion detection system called the “Lameness Locator.” Now, Kevin Keegan, a professor of equine surgery in the College of Veterinary Medicine at MU, has found that his Lameness Locator can detect lameness earlier than veterinarians using the traditional method of a subjective eye test. (more…)

In Real Time, Yale Scientists Watch Stem Cells at Work Regenerating Tissue

By Guest PostJuly 4, 2012Sciencealexander brown coxe, ann m haberman, cancer, connective tissue, david g gonzalez, disease, elizabeth deschene, embryonic development, giovanni zito, hair follicle, ichiko saotome, imaging technique, mammal, mesenchyme, panteleimon rompolas, photon intravital microscopy, postdoctoral fellowship, regenerate tissue, stem cell, Technology, therapeutic purpose, valentina greco

Scientists have for the first time watched and manipulated stem cells as they regenerate tissue in an uninjured mammal, Yale researchers report July 1 online in the journal Nature.

Using a sophisticated imaging technique, the researchers also demonstrated that mice lacking a certain type of cell do not regrow hair. The same technique could shed light on how stem cells interact with other cells and trigger repairs in a variety of other organs, including lung and heart tissue.

“This tells us a lot about how the tissue regeneration process works,” said Valentina Greco, assistant professor of genetics and of dermatology at the Yale Stem Cell Center, researcher for the Yale Cancer Center and senior author of the study. (more…)

Mass Extinctions Reset the Long-Term Pace of Evolution

By Guest PostJuly 3, 2012Scienceandrew z krug, animal kingdom, birth rate, bivalve, chicago esque, david jablonski, evolution, evolutionary rate, fossil, fossil mollusk, jurassic period, maryland outcrop, mass extinction, oysters, pace of evolution, paleontologist, pleistocene epoch, richard bambach, scallops, species diversification, time boundaries, university of chicago

A new study indicates that mass extinctions affect the pace of evolution, not just in the immediate aftermath of catastrophe, but for millions of years to follow. The study’s authors, University of Chicago’s Andrew Z. Krug and David Jablonski, will publish their findings in the August issue of the journal Geology.

Scientists expected to see an evolutionary explosion immediately following a mass extinction, but Krug and Jablonski’s findings go far beyond that.

“There’s some general sense that the event happens, there’s some aftermath and then things return to normal,” said Krug, a research scientist in geophysical sciences at UChicago. But in reality, Krug said, “Things don’t return to what they were before. They operate at a different pace, sometimes more rapidly, other times more slowly. Evolutionary rates shift, and that shift is permanent until the next mass extinction.” (more…)

Programmable DNA Scissors Found for Bacterial Immune System

By Guest PostJuly 2, 2012Scienceartificial enzymes, bacterial immune system, bacterial protein, dna scissors, gene targeting, genome editing

Discovery Could Lead to Editing Tool for Genomes

Genetic engineers and genomics researchers should welcome the news from the Lawrence Berkeley National Laboratory (Berkeley Lab) where an international team of scientists has discovered a new and possibly more effective means of editing genomes. This discovery holds potentially big implications for advanced biofuels and therapeutic drugs, as genetically modified microorganisms, such as bacteria and fungi, are expected to play a key role in the green chemistry production of these and other valuable chemical products. (more…)

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