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MSU Researchers Show How New Viruses Evolve, And in Some Cases, Become Deadly

By Guest PostJanuary 27, 2012Sciencebacteria, beacon, beneficial mutation, bird flu, devin dobias, e coli bacterium, evolve, jeff barrick, justin meyer, lambda, michigan state university, mutation, natural selection, Netherlands, new virus, ompf protein, ribbon diagram, richard lenski, ryan quick, Science, survival of the fittest, united states, virus evolution

EAST LANSING, Mich. — In the current issue of Science, researchers at Michigan State University demonstrate how a new virus evolves, which sheds light on how easy it can be for diseases to gain dangerous mutations.

The scientists showed for the first time how the virus called “Lambda” evolved to find a new way to attack host cells, an innovation that took four mutations to accomplish. This virus infects bacteria, in particular the common E. coli bacterium. Lambda isn’t dangerous to humans, but this research demonstrated how viruses evolve complex and potentially deadly new traits, said Justin Meyer, MSU graduate student, who co-authored the paper with Richard Lenski, MSU Hannah Distinguished Professor of Microbiology and Molecular Genetics. (more…)

Researchers Uncover How New Melanoma Drug Accelerates Secondary Skin Cancers

By Guest PostJanuary 20, 2012Healthantoni ribas, braf mutation, cancer growth, cancer mutation, cancer treatment, drug, hematology, malignant cells, mechanism, mek inhibitor, melanoma cells, metastatic melanoma, mutated braf protein, mutation, oncogenic mutations, oncology, patients, plexxikon, ras mutation, roche, ruby family foundation, seaver institute, secondary skin cancers, side effect, skin squamous cell carcinomas, vemurafenib, zelboraf

Patients with metastatic melanoma taking the recently approved drug vemurafenib (marketed as Zelboraf) responded well to the twice-daily pill, but some of them developed a different, secondary skin cancer.

Now, researchers at UCLA’s Jonsson Comprehensive Cancer Center, working with investigators from the Institute of Cancer Research in London, Roche and Plexxikon, have elucidated the mechanism by which the drug excels at fighting melanoma but also allows for the development of skin squamous-cell carcinomas. (more…)

Close Family Ties Keep Microbial Cheaters in Check, Study Finds

By Guest PostDecember 16, 2011Scienceamoebae, Antarctica, canopies, clonal lineage, cosmopolitan groups, david queller, deserts, dicty, dictyostelium discoideum, e coli, evolution, forest park, genes, jennie kuzdzal fick, joan strassmann, kissing kin, life cycles, multicellular organisms, mutation, national science foundation, obligate cheaters, sam scheiner, sara fox, single cell, slime mold, social amoeba, st. louis, tropical forests, washington university

*Experiments on “slime mold” explain why almost all multicellular organisms begin life as a single cell*

Any multicellular animal, from a blue whale to a human being, poses a special challenge for evolution.

Most of the cells in its body will die without reproducing; only a privileged few will pass their genes to the next generation.

How could the extreme degree of cooperation required by multicellular existence actually evolve? Why aren’t all creatures unicellular individualists determined to pass on their own genes? (more…)

WHOI Teaming with Flatley Discovery Lab in Search for Effective Treatments for Cystic Fibrosis

By Guest PostOctober 13, 2011Health, Scienceantibiotics, biological and chemical processes of ocean microbes, cf, cftr, cftr gene, charlestown, chemical extracts, cystic fibrosis, cystic fibrosis trans-membrane conductance regulator, flatley discovery lab, fungi, gene, john flatley, marine actinomycetes, marine microbes, marine microbial extracts, membrane, microbes, microbial infection biofilm, mutation, phytoplankton, respiratory disease, richard fitzpatrick, sodium transport, susan k. avery, therapeutic agents for cystic fibrosis, tracy mincer, whoi, woods hole oceanographic institution

The Woods Hole Oceanographic Institution (WHOI) has signed a $1.18 million agreement with the Flatley Discovery Lab in Charlestown, Mass., to investigate and supply marine microbial extracts as possible treatments for cystic fibrosis (CF).

The life-shortening respiratory disease has eluded attempts at a cure, although researchers have been successful in some cases at adding years to a person’s lifespan, primarily through treatment with antibiotics. (more…)

Why Coffee Protects Against Diabetes

By Guest PostJanuary 13, 2011Health, Scienceamerican diabetes association, biological activity, body, brian chen, cancer, cardiovascular disease, coffee, coffee consumption, david geffen, decaffeinated coffee, diabetes, estrogen, gene, julie buring, molecular mechanism, morning elixir, mutation, non coffee drinkers, plasma levels, protective effect, protein, sex hormone binding globulin, sex hormones, shbg, simin liu, testosterone, tolerance to insulin, type 2 diabetes

*Researchers discover molecular mechanism behind drink’s prophylactic effect*

Coffee, that morning elixir, may give us an early jump-start to the day, but numerous studies have shown that it also may be protective against type 2 diabetes. Yet no one has really understood why.

Now, researchers at UCLA have discovered a possible molecular mechanism behind coffee’s protective effect. A protein called sex hormone–binding globulin (SHBG) regulates the biological activity of the body’s sex hormones, testosterone and estrogen, which have long been thought to play a role in the development of type 2 diabetes. And coffee consumption, it turns out, increases plasma levels of SHBG. (more…)

How Pathogens Hijack Host Plants

By Guest PostNovember 27, 20101 commentSciencearabidopsis, bacteria, cell membrane, cells, diabetes, fluorescence resonance energy transfer, frank white, fret, fungi, global crop, infestation, li-qing chen, mustard, mutation, novel transporters, organism, pathogen infection, pathogenic bacteria, pathogens, plant nutrients, pore proteins, protein genes, sensor-based technology, sugar efflux, sugar-pumping mechanism, sweets

Palo Alto, CA — Infestation by bacteria and other pathogens result in global crop losses of over $500 billion annually. A research team led by the Carnegie Institution’s Department of Plant Biology developed a novel trick for identifying how pathogens hijack plant nutrients to take over the organism. They discovered a novel family of pores that transport sugar out of the plant. Bacteria and fungi hijack the pores to access the plant sugar for food. The first goal of any pathogen is to access the host’s food supply to allow them to reproduce in large numbers. This is the first time scientists have a direct handle on controlling the food supply to pathogens and thus a new means to prevent a wide range of crop diseases and losses. (more…)

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