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Study stops stress-based drug relapse in rats

In a new study in Neuron, scientists identified specific key steps in the chain of events that causes stress-related drug relapse. They identified the exact region of the brain where the events take place in rat models and showed that by blocking a step, they could prevent stress-related relapse.

PROVIDENCE, R.I. [Brown University] — All too often, stress turns addiction recovery into relapse, but years of basic brain research have provided scientists with insight that might allow them develop a medicine to help. A new study in the journal Neuron pinpoints the neural basis for stress-related relapse in rat models to an unprecedented degree. The advance could accelerate progress toward a medicine that prevents stress from undermining addiction recovery. (more…)

Understanding Angelman syndrome: Study in Mice Yields Angelman Advance

By Guest PostFebruary 25, 2013Scienceangelman mice, angelman syndrome, arc, bdnf, ben philpot, brain, brain derived, brown university, clinical therapy, cn2097, cong cao, crystal yu, dartmouth college, dennis goebel, development of synapses, electrophysiological tests, flaws in gene, gene defect, growth factor, hippocampal tissue, hippocampus, john marshall, learning, long-term potentiation, ltp, mark spaller, memory, memory function, mengia rioult pedotti, negative effects, neural functions, neurological processes, neurotrophic factor, north Carolina, paolo migani, peptide like compound, protein, psd 95, study in mice, synaptic protein, ube3a, understanding angelman syndrome, university, wayne state university

In the journal PLoS Biology, a team of scientists reports experiments showing how the gene defect of Angelman syndrome disrupts neurological processes that may be needed for memory and learning. In tests in mice, the team showed that a novel compound could restore the healthy processes.

PROVIDENCE, R.I. [Brown University] — In a new study in mice, a scientific collaboration centered at Brown University lays out in unprecedented detail a neurological signaling breakdown in Angelman syndrome, a disorder that affects thousands of children each year, characterized by developmental delay, seizures, and other problems. With the new understanding, the team demonstrated how a synthesized, peptide-like compound called CN2097 works to restore neural functions impaired by the disease. (more…)

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Study stops stress-based drug relapse in rats

Understanding Angelman syndrome: Study in Mice Yields Angelman Advance