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More intestinal cells can absorb larger particles

By Guest PostAugust 22, 2013Sciencea peter morello, absorb, brown university, cells, daniel cho, edith mathiowitz, endocytosis in cells, enterocytes, finding in rats, insulin, intestinal cells, joshua reineke, larger particles, m, microfold, microspheres, phagocytosis, protein drugs, wayne state university, yu ting dingle

A new study reports that the small intestine uses more cells than scientists had realized to absorb microspheres large enough to contain therapeutic protein drugs, such as insulin. The finding in rats, published in the Proceedings of the National Academy of Sciences, is potentially good news for developing a means for oral delivery of such drugs.

PROVIDENCE, R.I. [Brown University] — The small intestine employs more cells and mechanisms than scientists previously thought to absorb relatively large particles, such as those that could encapsulate protein-based therapeutics like insulin, according to a new study. The findings, published the week of Aug. 5, 2013, in the Proceedings of the National Academy of Sciences, open another window for drug makers to increase absorption of medicines taken by mouth. (more…)

Understanding Angelman syndrome: Study in Mice Yields Angelman Advance

By Guest PostFebruary 25, 2013Scienceangelman mice, angelman syndrome, arc, bdnf, ben philpot, brain, brain derived, brown university, clinical therapy, cn2097, cong cao, crystal yu, dartmouth college, dennis goebel, development of synapses, electrophysiological tests, flaws in gene, gene defect, growth factor, hippocampal tissue, hippocampus, john marshall, learning, long-term potentiation, ltp, mark spaller, memory, memory function, mengia rioult pedotti, negative effects, neural functions, neurological processes, neurotrophic factor, north Carolina, paolo migani, peptide like compound, protein, psd 95, study in mice, synaptic protein, ube3a, understanding angelman syndrome, university, wayne state university

In the journal PLoS Biology, a team of scientists reports experiments showing how the gene defect of Angelman syndrome disrupts neurological processes that may be needed for memory and learning. In tests in mice, the team showed that a novel compound could restore the healthy processes.

PROVIDENCE, R.I. [Brown University] — In a new study in mice, a scientific collaboration centered at Brown University lays out in unprecedented detail a neurological signaling breakdown in Angelman syndrome, a disorder that affects thousands of children each year, characterized by developmental delay, seizures, and other problems. With the new understanding, the team demonstrated how a synthesized, peptide-like compound called CN2097 works to restore neural functions impaired by the disease. (more…)

Energy Savings – Easy as Dirt, Heat, Pressure

By Guest PostNovember 28, 2012Environment, Sciencecar engine, dirt, donald morelli, electricity, energy, heat, industrial power plants, materials, materials science, michigan state university, minerals, natural minerals, pressure, synthesize, tetrahedrites, thermoelectric generation, thermoelectric material, waste heat, wayne state university, xu lu

By using common materials found pretty much anywhere there is dirt, a team of Michigan State University researchers have developed a new thermoelectric material.

This is important, they said, because the vast majority of heat that is generated from, for example, a car engine, is lost through the tail pipe. It’s the thermoelectric material’s job to take that heat and turn it into something useful, like electricity. (more…)

Principal Plays Surprising Role in Why New Teachers Quit

By Guest PostNovember 14, 2012Education, Generalashley keine, beginning teachers, ben pogodzinski, change schools, classroom management, curriculum, discipline, educational policy, elementary school journal, factor, Indiana, michigan, peter youngs, principal, profession, quit, relationship, school climate, state university, teacher, wayne state university, workload

EAST LANSING, Mich. — Why do so many beginning teachers quit the profession or change schools? Surprising new research finds it’s not a heavy workload or lack of resources that has the most significant effect, but instead the relationship between teachers and their principal.

Peter Youngs, associate professor of educational policy at Michigan State University and lead investigator on the study, said the findings reinforce the need for principals to serve as strong, supportive leaders in their schools. (more…)

Tag Archives: wayne state university

More intestinal cells can absorb larger particles

Understanding Angelman syndrome: Study in Mice Yields Angelman Advance

Energy Savings – Easy as Dirt, Heat, Pressure

Principal Plays Surprising Role in Why New Teachers Quit