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Understanding Angelman syndrome: Study in Mice Yields Angelman Advance

By Guest PostFebruary 25, 2013Scienceangelman mice, angelman syndrome, arc, bdnf, ben philpot, brain, brain derived, brown university, clinical therapy, cn2097, cong cao, crystal yu, dartmouth college, dennis goebel, development of synapses, electrophysiological tests, flaws in gene, gene defect, growth factor, hippocampal tissue, hippocampus, john marshall, learning, long-term potentiation, ltp, mark spaller, memory, memory function, mengia rioult pedotti, negative effects, neural functions, neurological processes, neurotrophic factor, north Carolina, paolo migani, peptide like compound, protein, psd 95, study in mice, synaptic protein, ube3a, understanding angelman syndrome, university, wayne state university

In the journal PLoS Biology, a team of scientists reports experiments showing how the gene defect of Angelman syndrome disrupts neurological processes that may be needed for memory and learning. In tests in mice, the team showed that a novel compound could restore the healthy processes.

PROVIDENCE, R.I. [Brown University] — In a new study in mice, a scientific collaboration centered at Brown University lays out in unprecedented detail a neurological signaling breakdown in Angelman syndrome, a disorder that affects thousands of children each year, characterized by developmental delay, seizures, and other problems. With the new understanding, the team demonstrated how a synthesized, peptide-like compound called CN2097 works to restore neural functions impaired by the disease. (more…)

Body Rebuilding: Scientists Regenerate Muscle in Mice

By Guest PostDecember 10, 2011Sciencebiopolymer microthreads, blood clot, cellthera, clinical therapy, cloning, fibrin microthreads, george pins, human muscle cells, implanted cells, leg muscle, mammalian skeletal muscles, mouse, muscle repair, muscle trauma, raymond page, stem cell, threads, tissue restoration, worcester polytechnic institute, wound, wpi

*New Study Uses Reprogrammed Human Cells and Bioengineered Microthreads*

A team of scientists from Worcester Polytechnic Institute (WPI) and CellThera, a private company located in WPI’s Life Sciences and Bioengineering Center, have regenerated functional muscle tissue in mice, opening the door for a new clinical therapy to treat people who suffer major muscle trauma.

The team used a novel protocol to coax mature human muscle cells into a stem cell-like state and grew those reprogrammed cells on biopolymer microthreads. The threads were placed in a wound created by surgically removing a large section of leg muscle from a mouse. Over time, the threads and cells restored near-normal function to the muscle, as reported in the paper “Restoration of Skeletal Muscle Defects with Adult Human Cells Delivered on Fibrin Microthreads”, published in the current issue of the journal Tissue Engineering. Surprisingly, the microthreads, which were used simply as a scaffold to support the reprogrammed human cells, actually seemed to accelerate the regeneration process by recruiting progenitor mouse muscle cells, suggesting that they alone could become a therapeutic tool for treating major muscle trauma. (more…)

Tag Archives: clinical therapy

Understanding Angelman syndrome: Study in Mice Yields Angelman Advance

Body Rebuilding: Scientists Regenerate Muscle in Mice