UCLA researchers discover new point of attack for drug therapy
Alzheimer’s disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as amyloid-beta, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.
For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a “target” — a structure they can bind to, thereby preventing the toxic actions of Abeta. (more…)
Molecular vibrations, rather than molecular shape, give substances their distinct smell according to a new study by UCL scientists.
In a study designed to find out how smell is written into a molecule’s structure, scientists tested whether changing how a molecule vibrates on a nano-scale changes its smell.
Molecules are made of atoms connected by bonds. The arrangement of bonds and atoms defines the vibration of the molecule. Chemists can therefore identify molecules by their vibrations, using a spectroscope. (more…)
Microbe-eating flies from at least three different locations around the world recently have evolved into herbivores, feeding on some of the most toxic plants on Earth. Fly detectives and UA evolutionary biologists Noah Whiteman and Richard Lapoint are trying to find out what genetic pathways led the flies to such a major change of lifestyle.
For millennia, they buzzed through the woods, contentedly munching yeasts off the surfaces of leaves, bracken and rotting duff on the forest floor. But now, flies in the family Drosophilidae, whose disparate members dwell in areas all across the planet, have evolved into all-out vegetarians with a wicked diet of plants that are deadly to most other organisms.
What, University of Arizona scientists would like to know, has caused these flies, yeast-feeders for nearly 80 million years, to independently go cold turkey with respect to their formerly meaty diets? (more…)
Ridges in impact craters on Mars appear to be fossils of cracks in the Martian surface, formed by minerals deposited by flowing water. Water flowing beneath the surface suggests life may once have been possible on Mars.
PROVIDENCE, R.I. [Brown University] — Networks of narrow ridges found in impact craters on Mars appear to be the fossilized remnants of underground cracks through which water once flowed, according to a new analysis by researchers from Brown University.
The study, in press in the journal Geophysical Research Letters, bolsters the idea that the subsurface environment on Mars once had an active hydrology and could be a good place to search for evidence of past life. The research was conducted by Lee Saper, a recent Brown graduate, with Jack Mustard, professor of geological sciences. (more…)
COLUMBUS, Ohio — It weighs half as much as a sports car, and turns on a dime—so its no surprise that the electric car being developed at Ohio State University needs an exceptional traction and motion control system to keep it on the road.
With four wheels that turn independently, each with its own built-in electric motor and set of batteries, the experimental car is the only one of its kind outside of commercial carmakers’ laboratories. (more…)
Berkeley Lab scientists devise new tools for detecting previously unknown tree mortality.
The Earth’s forests perform a well-known service to the planet, absorbing a great deal of the carbon dioxide pollution emitted into the atmosphere from human activities. But when trees are killed by natural disturbances, such as fire, drought or wind, their decay also releases carbon back into the atmosphere, making it critical to quantify tree mortality in order to understand the role of forests in the global climate system. Tropical old-growth forests may play a large role in this absorption service, yet tree mortality patterns for these forests are not well understood.
Now scientist Jeffrey Chambers and colleagues at the U.S. Department of Energy’s (DOE) Lawrence Berkeley National Laboratory (Berkeley Lab) have devised an analytical method that combines satellite images, simulation modeling and painstaking fieldwork to help researchers detect forest mortality patterns and trends. This new tool will enhance understanding of the role of forests in carbon sequestration and the impact of climate change on such disturbances. (more…)
ANN ARBOR — Michigan health officials are using HIV surveillance technologies to assist in enforcing a “health threat” law that makes it illegal for HIV-positive people to have sex without disclosing their status.
A new University of Michigan study reveals that health officials employ the state’s names reporting database, alongside partner services referrals, for law enforcement purposes. However, this is bad social policy for a variety of reasons, says Trevor Hoppe, the study’s author and a doctoral candidate in sociology and women’s studies. (more…)
At the heart of computing are tiny crystals that transmit and store digital information’s ones and zeroes. Today these are hard and brittle materials. But cheap, flexible, nontoxic organic molecules may play a role in the future of hardware.
A team led by the University of Washington in Seattle and the Southeast University in China discovered a molecule that shows promise as an organic alternative to today’s silicon-based semiconductors. The findings, published this week in the journal Science, display properties that make it well suited to a wide range of applications in memory, sensing and low-cost energy storage. (more…)
