Tag Archives: university

UMass Amherst Biochemists Trap a Chaperone Machine in Action, Opening Pathway to Possible New Cancer Treatment

AMHERST, Mass. – Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists at the University of Massachusetts Amherst led by Lila Gierasch have deciphered key steps in the mechanism of the Hsp70 molecular machine by “trapping” this chaperone in action, providing a dynamic snapshot of its mechanism.

She and colleagues describe this work in the current issue of Cell. Gierasch’s research on Hsp70 chaperones is supported by a long-running grant to her lab from NIH’s National Institute for General Medical Sciences. (more…)

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Research by CU-Boulder Physicists Creates ‘Recipe Book’ for Building New Materials

By showing that tiny particles injected into a liquid crystal medium adhere to existing mathematical theorems, physicists at the University of Colorado Boulder have opened the door for the creation of a host of new materials with properties that do not exist in nature.

The findings show that researchers can create a “recipe book” to build new materials of sorts using topology, a major mathematical field that describes the properties that do not change when an object is stretched, bent or otherwise “continuously deformed.” Published online Dec. 23 in the journal Nature, the study also is the first to experimentally show that some of the most important topological theorems hold up in the real material world, said CU-Boulder physics department Assistant Professor Ivan Smalyukh, a study senior author. (more…)

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UMass Amherst Climate Model is First to Study Climate Effects of Arctic Hurricanes

AMHERST, Mass. – Though it seems like an oxymoron, Arctic hurricanes happen, complete with a central “eye,” extreme low barometric pressure and towering 30-foot waves that can sink small ships and coat metal platforms with thick ice, threatening oil and gas exploration. Now climate scientists at the University of Massachusetts Amherst and in England report the first conclusive evidence that Arctic hurricanes, also known as polar lows, play a significant role in driving ocean water circulation and climate.

Results point to potentially cooler conditions in Europe and North America in the 21st century than other models predict. (more…)

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JILA Physicists Achieve Elusive ‘Evaporative Cooling’ of Molecules

Achieving a goal considered nearly impossible, JILA physicists have chilled a gas of molecules to very low temperatures by adapting the familiar process by which a hot cup of coffee cools.

JILA is a joint institute of the University of Colorado Boulder and the National Institute of Standards and Technology located on the CU-Boulder campus. (more…)

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Bumblebees do Best Where There is Less Pavement and More Floral Diversity

AUSTIN, Texas — Landscapes with large amounts of paved roads and impervious construction have lower numbers of ground-nesting bumblebees, which are important native pollinators, a study from The University of Texas at Austin and the University of California, Berkeley shows.

The study suggests that management strategies that reduce the local use of pavement and increase natural habitat within the landscape could improve nesting opportunities for wild bees and help protect food supplies around the word. (more…)

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Super-fine Sound Beam could one Day be an Invisible Scalpel

ANN ARBOR — A carbon-nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.

Today’s ultrasound technology enables far more than glimpses into the womb. Doctors routinely use focused sound waves to blast apart kidney stones and prostate tumors, for example. The tools work primarily by focusing sound waves tightly enough to generate heat, says Jay Guo, a professor of electrical engineering and computer science, mechanical engineering, and macromolecular science and engineering. Guo is a co-author of a paper on the new technique published in the current issue of Nature’s journal Scientific Reports. (more…)

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Plan C: ‘All Roads Lead Back to Boehner’ – UMD’s Kettl

University of Maryland School of Public Policy Dean Don Kettl on where the fiscal cliff negotiations head after Plan B fails:

“For the Republicans, this is a very weak situation. They’re struggling to get their mojo back after the election. It’s very clear they don’t know which way to go and they aren’t willing to follow anyone to get them there.

For the Democrats, there will be a powerful temptation to allow the Republicans to swing in the wind. It’s hard to beat something with nothing, and right now the Republicans have nothing to bring to the table. The Democrats will surely enjoy watching this for a few days, and watching the approval ratings of the House Republicans drop a few more notches. (more…)

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