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Molecular map reveals genetic origins of 21 autoimmune diseases

By Guest PostNovember 5, 2014Healthalyssa coyne, anja karliczek, autoimmune diseases, bakterienbildung, cause, david hafler, immune system, isaiah eterno muchilwa, lorenz michel, mais silos, messgeraet, multiple sclerosis, muscle paralysis, pamela anderson, single nucleotide polymorphisms, snps

Scientists have created a molecular map that pinpoints genetic variants that play a role in 21 different autoimmune diseases, they report Oct. 27 in the journal Nature.

Researchers at Yale, the University of California-San Francisco (UCSF), and the Broad Institute of MIT and Harvard developed a sophisticated mathematical model and created maps of different cell types that together enabled them to identify which variants cause the immune response to go awry and cause specific diseases. (more…)

Solving an Evolutionary Puzzle

By Guest PostFebruary 17, 2014Environment, Natureadam reitzel, ahr pathway, ahr2, ahr2 system, aryl hydrocarbon receptor, atlantic ecology division, atlantic killifish, bedford harbor killifish, candidate gene, contaminated environment, contaminated sediment, diana franks, diane nacci, dna sequence, evolutionary puzzle, genetic resistance, harbor, heavy metals, hudson river, mark hahn, new bedford, oceanographic institution, pathway, PCBs, polychlorinated biphenyls, receptor protein, sibel karchner, single nucleotide polymorphisms, snps, solving, whoi, woods hole

New Bedford Harbor pollution prompts PCB-resistance in Atlantic killifish

For four decades, waste from nearby manufacturing plants flowed into the waters of New Bedford Harbor—an 18,000-acre estuary and busy seaport. The harbor, which is contaminated with polychlorinated biphenyls (PCBs) and heavy metals, is one of the EPA’s largest Superfund cleanup sites.

It’s also the site of an evolutionary puzzle that researchers at Woods Hole Oceanographic Institution (WHOI) and their colleagues have been working to solve. (more…)

Geoscientists Find Key to Why Some Patients Get Infections from Cardiac Implants

By Guest PostOctober 26, 2011Health, Scienceamericans, antibiotics, atomic force microscopy, bacteria adhere to mineral surfaces, bacterial and human proteins, bacterial cells, biofilm, biofilm formation, biofilm of persistent bacteria, blood infection bacteremia, charles darwin, common human blood protein, contaminated device, deadly blood infection, defibrillators, duke university medical center, enriqueta barrera, eric taylor, fibronectin, fibronectin binding protein a, gene mutations, genetic variants, geobiologists, heart implants, human body, implanted cardiac devices, infections, l barth reller, molecular dynamics simulations, nadia casillas ituarte, national science foundation, ohio state university, pacemakers, patients with implants, prosthetic cardiac valves, proteins of infectious bacteria, ruchirej yongsunthon, single nucleotide polymorphisms, snips, snps, solid substrate, staph bacteria, staphylococcus aureus, steven lower, supaporn lamlertthon, united states, vance fowler

*Bacterial cells have gene mutations that allow them to ‘stick’ to the devices*

New research suggests that some patients develop a potentially deadly blood infection from their implanted cardiac devices because bacterial cells in their bodies have gene mutations that allow them to stick to the devices.

Geoscientists were the major contributors to the finding.

Proceedings of the National Academy of Sciences published the study results online this week. (more…)

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Molecular map reveals genetic origins of 21 autoimmune diseases

Solving an Evolutionary Puzzle

Geoscientists Find Key to Why Some Patients Get Infections from Cardiac Implants